3-Hydroxybutyric acid | CAS:625-71-8 | Manufacturer ChemFaces

3-Hydroxybutyric acid

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Description:

3-Hydroxybutyric acid is a ketone body and acts as an indicator of energy balance and a central regulator of energy homeostasis. 3-Hydroxybutyric acid has anesthetic actions, which are due to the metabolite's abilities to alter physical properties of cell membranes, leading to indirect effects on membrane protein function.

In vitro:

Anal Biochem. 2012 Jun 15;425(2):114-6.

Enzymatic fluorometric microplate assay for quantitative analysis of 3-hydroxybutyric acid in mouse plasma.[Pubmed: 22449496]

3-Hydroxybutyric acid (3HB) is a ketone body and acts as an indicator of energy balance and a central regulator of energy homeostasis.
METHODS AND RESULTS:
We report the application of a sensitive fluorometric assay for the quantitative determination of 3HB. The assay is based on the oxidation of 3HB by 3HB dehydrogenase and on the diaphorase-resazurin amplifying system.
CONCLUSIONS:
This simple assay enables the measurement of changes in 3HB levels in the blood of normal mice by very small volume sample collection. Therefore, this assay will be useful for in vivo studies of small animals.

3-Hydroxybutyric acid Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Langmuir. 2013 Feb 12;29(6):1948-55.

3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness.[Pubmed: 23339286]

METHODS AND RESULTS:
3-Hydroxybutyric acid (also referred to as β-hydroxybutyric acid or BHB), a small molecule metabolite whose concentration is elevated in type I diabetes and diabetic coma, was found to modulate the properties of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayers when added to the subphase at clinical concentrations. This is a key piece of evidence supporting the hypothesis that the anesthetic actions of BHB are due to the metabolite's abilities to alter physical properties of cell membranes, leading to indirect effects on membrane protein function. Pressure-area isotherms show that BHB changes the compressibility of the monolayer and decrease the size of the two-phase coexistence region. Epi-fluorescent microscopy further reveals that the reduction of the coexistence region is due to the significant reduction in morphology of the liquid condensed domains in the two-phase coexistence region.
CONCLUSIONS:
These changes in monolayer morphology are associated with the diminished interfacial viscosity of the monolayers (measured using an interfacial stress rheometer), which gives insight as to how changes in phase and structure may contribute to membrane function.

Product Name	3-Hydroxybutyric acid
Price:
CAS No.:	625-71-8
Catalog No.:	CFN90053
Molecular Formula:	C₄H₈O₃
Molecular Weight:	104.1 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Markers Compound Library General anesthesia Compound Library Miscellaneous Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	9.6061 mL	48.0307 mL	96.0615 mL	192.123 mL	240.1537 mL
5 mM	1.9212 mL	9.6061 mL	19.2123 mL	38.4246 mL	48.0307 mL
10 mM	0.9606 mL	4.8031 mL	9.6061 mL	19.2123 mL	24.0154 mL
50 mM	0.1921 mL	0.9606 mL	1.9212 mL	3.8425 mL	4.8031 mL
100 mM	0.0961 mL	0.4803 mL	0.9606 mL	1.9212 mL	2.4015 mL

CFN98128	Butanol	71-36-3	74.12	C₄H₁₀O
CFN90053	3-Hydroxybutyric acid	625-71-8	104.1	C₄H₈O₃
CFN90112	Methyl 3-methoxyacrylate	34846-90-7	116.12	C₅H₈O₃
CFN97077	Methyl levulinate	624-45-3	130.1	C₆H₁₀O₃
CFN99100	Succinic acid	110-15-6	118.1	C₄H₆O₄
CFN99201	Fumaric acid	110-17-8	116.1	C₄H₄O₄
CFN90558	Malic acid	6915-15-7	134.09	C₄H₆O₅
CFN97130	Malic acid 4-Me ester	66178-02-7	148.1	C₅H₈O₅
CFN93181	Tartaric acid	87-69-4	150.09	C₄H₆O₆
CFN98551	Citric acid	77-92-9	192.12	C₆H₈O₇