Delphinidin chloride | CAS:528-53-0 | Manufacturer ChemFaces

Delphinidin chloride

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $175.7 / In-stock
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Description:

Delphinidin chloride is a dietary antioxidant. Delphinidin is a naturally occurring inhibitor of vascular endothelial growth factor receptors, possesses important antiangiogenic properties that may be helpful for the prevention and treatment of cancer.

Targets:

VEGFR

In vitro:

Environ Toxicol . 2021 Aug;36(8):1557-1566.

Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells[Pubmed: 33955636]

Abstract Delphinidin is an anthocyanin that belongs to the group of flavonoids that exert numerous biological activities. However, the molecular mechanisms underlying the anticancer effects of delphinidin remain poorly understood. In our study we analyzed delphinidin modulate STAT-3 and MAPKinase signaling thereby inhbits cell proliferation and promote apoptosis. Our study demonstrated that delphinidin treatment significantly reduced the viability of human colon cancer HCT116 in a concentration-dependent manner. We noticed that delphinidin effectively induced oxidative stress-mediated apoptosis by generating intracellular ROS, decreasing antioxidant levels, inducing lipid peroxidation, and single-strand break on colon cancer cells. In this study, we observed that delphinidin treatment alters the mitochondrial membrane potential, thereby induces apoptosis was closely associated with the induction of pro-apoptotic Bax, Caspase- 3,8 & 9, cytochrome C, and inhibition of anti-apoptotic protein expression. Studies on STAT-3 and MAPKinase signaling showed delphinidin inhibited the phosphorylation of these transcription factors' activity. Inhibition of STAT-3, p38, and ERK1/2 phosphorylation and modulation pro-apoptotic protein expression might be responsible for the anticancer activity of delphinidin in colon cancer cells.

Delphinidin chloride Description

Source:	The fruits of Vaccinium myrtillus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Delphinidin chloride
Price:	$380 / 10mg
CAS No.:	528-53-0
Catalog No.:	CFN92033
Molecular Formula:	C₁₅H₁₁ClO₇
Molecular Weight:	338.7 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The fruits of Vaccinium myrtillus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Vasoprotective Compound Library Flavonoids Compound Library VEGFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9525 mL	14.7623 mL	29.5247 mL	59.0493 mL	73.8116 mL
5 mM	0.5905 mL	2.9525 mL	5.9049 mL	11.8099 mL	14.7623 mL
10 mM	0.2952 mL	1.4762 mL	2.9525 mL	5.9049 mL	7.3812 mL
50 mM	0.059 mL	0.2952 mL	0.5905 mL	1.181 mL	1.4762 mL
100 mM	0.0295 mL	0.1476 mL	0.2952 mL	0.5905 mL	0.7381 mL

CFN91870	Delphinidin-3-O-sambubioside-5-O-glucoside chloride	36415-91-5	795.1	C₃₂H₃₉ClO₂₁
CFN92034	Peonidin chloride	134-01-0	336.7	C₁₆H₁₃ClO₆
CFN92047	Peonidin-3-O-arabinoside chloride	524943-91-7	468.8	C₂₁H₂₁ClO₁₀
CFN92045	Peonidin-3-O-galactoside chloride	28148-89-2	498.9	C₂₂H₂₃ClO₁₁
CFN92046	Peonidin-3-O-glucoside chloride	6906-39-4	498.9	C₂₂H₂₃ClO₁₁
CFN91868	Peonidin-3,5-O-diglucoside chloride	132-37-6	661.0	C₂₈H₃₃ClO₁₆

CFN99740	Cyanidin-3-O-glucoside chloride	7084-24-4	449.38	C₂₁H₂₁O₁₁
CFN92041	Cyanidin-3-O-arabinoside chloride	111613-04-8	454.8	C₂₀H₁₉ClO₁₀
CFN92040	Cyanidin-3-O-galactoside chloride	27661-36-5	484.9	C₂₁H₂₁ClO₁₁