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3alpha-dihydrocadambine
3alpha-dihydrocadambine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 3alpha-dihydrocadambine
Price:
CAS No.: 54483-84-0
Catalog No.: CFN80224
Molecular Formula: C27H34N2O10
Molecular Weight: 546.22 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The heartwoods of Anthocephalus cadamba
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 3alpha-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats.
In vivo:
Planta Med. 1985 Oct;51(5):424-7.
Hypotensive action of 3alpha-dihydrocadambine, an indole alkaloid glycoside of uncaria hooks1.[Pubmed: 17342601]
3alpha-dihydrocadambine exhibited dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. Its activity was much stronger and longer-lasting than that of rhynchophylline. In anesthetized dogs, it caused dilation of the vertebral, femoral and common carotid arteries, and had almost no effect on the coronary artery, whereas it had almost no significant activity in isolated canine arterial strip preparations.
3alpha-dihydrocadambine Description
Source: The heartwoods of Anthocephalus cadamba
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8308 mL 9.1538 mL 18.3076 mL 36.6153 mL 45.7691 mL
5 mM 0.3662 mL 1.8308 mL 3.6615 mL 7.3231 mL 9.1538 mL
10 mM 0.1831 mL 0.9154 mL 1.8308 mL 3.6615 mL 4.5769 mL
50 mM 0.0366 mL 0.1831 mL 0.3662 mL 0.7323 mL 0.9154 mL
100 mM 0.0183 mL 0.0915 mL 0.1831 mL 0.3662 mL 0.4577 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 2003 Feb;51(2):232-3.
Gluco-indole alkaloids from Nauclea cadamba in Thailand and transformation of 3 alpha-dihydrocadambine into the indolopyridine alkaloid, 16-carbomethoxynaufoline.[Pubmed: 12576667]

METHODS AND RESULTS:
Three monoterpenoid gluco-indole alkaloids, 3beta-isodihydrocadambine, cadambine, and 3alpha-dihydrocadambine, were isolated from Nauclea cadamba ROXB. growing in Thailand. The stereochemistry at C19 in 3beta-isodihydrocadambine was elucidated to be R by spectroscopic analysis.
CONCLUSIONS:
Treatment of 3alpha-dihydrocadambine with beta-glucosidase in aqueous ammonium acetate solution gave an indolopyridine alkaloid, 16-carbomethoxynaufoline, and an unusually rearranged compound.
CFN802243alpha-dihydrocadambine54483-84-0546.22C27H34N2O10
CFN92640Vallesiachotamine5523-37-5350.4C21H22N2O3
CFN92641Isovallesiachotamine34384-71-9350.4C21H22N2O3
CFN96096(16R)-E-Isositsirikine6519-27-3354.5C21H26N2O3
CFN95566Geissoschizine439-66-7352.4C21H24N2O3
CFN89459Geissoschizine methyl ether60314-89-8366.45C22H26N2O3
CFN96218Sitsirikine1245-00-7354.5C21H26N2O3
CFN90615Hirsuteine35467-43-7366.45C22H26N2O3
CFN90617Hirsutine7729-23-9368.47C22H28N2O3
CFN97115(16R)-Dihydrositsirikine6519-26-2356.5 C21H28N2O3
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