3-O-Acetyl-11-keto-beta-boswellic acid | CAS:67416-61-9

3-O-Acetyl-11-keto-beta-boswellic acid

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Product Name	3-O-Acetyl-11-keto-beta-boswellic acid
Price:	$80 / 20mg
CAS No.:	67416-61-9
Catalog No.:	CFN90531
Molecular Formula:	C₃₂H₄₈O₅
Molecular Weight:	512.72 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Boswellia carterii Birdw.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $28.1 / In-stock
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Description:

3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM.

In vitro:

Toxicol Mech Methods. 2006;16(4):199-226.

Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)).[Pubmed: 20021046]

The novel anti-inflammatory properties of the gum resin derived from Boswellia serrata, also known as Salai guggal in Ayurvedic medicine, are well recognized and highly recommended for human consumption. The active constituents of the gum resin are boswellic acids (BAs). Among the BAs, 3-O-Acetyl-11-keto-beta-boswellic acid potently inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM.
CONCLUSIONS:
We developed a novel Boswellia serrata extract (5-Loxin(R)) enriched with 30% 3-O-Acetyl-11-keto-beta-boswellic acid (US Patent 2004/0073060A1).

Biomed Chromatogr. 2014 Oct;28(10):1402-8.

Comparative pharmacokinetic study of two boswellic acids in normal and arthritic rat plasma after oral administration of Boswellia serrata extract or Huo Luo Xiao Ling Dan by LC-MS.[Pubmed: 24806456]

11-keto-β-boswellic acid and 3-O-Acetyl-11-keto-beta-boswellic acid following oral administration of HLXLD or Boswellia serrata extract alone in normal and arthritic rats.
METHODS AND RESULTS:
An LC-MS method was developed and validated for the determination of 11-keto-β-boswellic acid and 3-O-Acetyl-11-keto-beta-boswellic acid in the comparative pharmacokinetic study. The results showed that there were significant differences in pharmacokinetic parameters between normal and arthritic groups. Interestingly, the absorptions of two boswellic acids were significantly higher in HLXLD than Boswellia serrata extract alone, indicating the synergistic effect of other herbal ingredients in HLXLD.
CONCLUSIONS:
This comparative pharmacokinetic study provided direct evidence supporting the notion that the efficacy of a complex mixture such as HLXLD is better than that of single components in treating human diseases.

3-O-Acetyl-11-keto-beta-boswellic acid Description

Source:	The herbs of Boswellia carterii Birdw.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Cytotoxic Compound Library Anti-arthritic Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9504 mL	9.7519 mL	19.5038 mL	39.0076 mL	48.7596 mL
5 mM	0.3901 mL	1.9504 mL	3.9008 mL	7.8015 mL	9.7519 mL
10 mM	0.195 mL	0.9752 mL	1.9504 mL	3.9008 mL	4.876 mL
50 mM	0.039 mL	0.195 mL	0.3901 mL	0.7802 mL	0.9752 mL
100 mM	0.0195 mL	0.0975 mL	0.195 mL	0.3901 mL	0.4876 mL

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CFN99881	Triptocallic acid A	190906-61-7	472.7	C₃₀H₄₈O₄
CFN99821	22-Hydroxy-3-oxo-12-ursen-30-oic acid	173991-81-6	470.7	C₃₀H₄₆O₄
CFN90221	Beta-boswellic acid	631-69-6	456.70	C₃₀H₄₈O₃
CFN90530	3-O-Acetyl-beta-boswellic acid	5968-70-7	498.74	C₃₂H₅₀O₄
CFN90152	11-Keto-beta-boswellic acid	17019-92-0	470.68	C₃₀H₄₆O₄
CFN90531	3-O-Acetyl-11-keto-beta-boswellic acid	67416-61-9	512.72	C₃₂H₄₈O₅
CFN95335	9,11-Dehydro-beta-boswellic acid	471-65-8	454.7	C₃₀H₄₆O₃
CFN70260	3-O-Acetyl 9,11-dehydro beta-boswellic acid	122651-20-1	496.7	C₃₂H₄₈O₄