4-(3,4-Dimethoxyphenyl)-3-buten-1-ol | CAS:69768-97-4

4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

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Product Name	4-(3,4-Dimethoxyphenyl)-3-buten-1-ol
Price:
CAS No.:	69768-97-4
Catalog No.:	CFN97183
Molecular Formula:	C₁₂H₁₆O₃
Molecular Weight:	208.3 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Orophea yunnanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypopigmentation-associated diseases.

Targets:

ERK | p38

In vitro:

PLOS ONE, 2015, 10(11):e0141988.

(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.[Reference: WebLink]

METHODS AND RESULTS:
We investigated the potential melanogenic effect of compounds from Zingiber cassumunar Roxb. Our data revealed that chloroform-soluble extract of Z. cassumunar enhanced melanin synthesis in B16F10 melanoma cells. Among the components of the chloroform extract, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol (4-(3,4-Dimethoxyphenyl)-3-buten-1-ol, DMPB) increased melanogenesis in both B16F10 cells and human primary melanocytes. In B16F10 cells, DMPB enhanced the activation of ERK and p38, and the level of tyrosinase. Although the level of microphthalmia-associated transcription factor was unchanged in DMPB-treated B16F10 cells, DMPB increased levels and nuclear localization of upstream stimulating factor-1 (USF1). Consistently, DMPB-mediated melanin synthesis was diminished in USF1-knockdown cells. Furthermore, DMPB induced hyperpigmentation in brown guinea pigs in vivo.
CONCLUSIONS:
Together, these data suggest that DMPB may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypopigmentation-associated diseases.

4-(3,4-Dimethoxyphenyl)-3-buten-1-ol Description

Source:	The herbs of Orophea yunnanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library p38 Inhibitor Library ERK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.8008 mL	24.0038 mL	48.0077 mL	96.0154 mL	120.0192 mL
5 mM	0.9602 mL	4.8008 mL	9.6015 mL	19.2031 mL	24.0038 mL
10 mM	0.4801 mL	2.4004 mL	4.8008 mL	9.6015 mL	12.0019 mL
50 mM	0.096 mL	0.4801 mL	0.9602 mL	1.9203 mL	2.4004 mL
100 mM	0.048 mL	0.24 mL	0.4801 mL	0.9602 mL	1.2002 mL

CFN97183	4-(3,4-Dimethoxyphenyl)-3-buten-1-ol	69768-97-4	208.3	C₁₂H₁₆O₃
CFN99692	4-(3,4-Dimethoxyphenyl)-3-butene-1,2-diol	164661-12-5	224.3	C₁₂H₁₆O₄
CFN96471	Turmeronol A	131651-37-1	232.32	C₁₅H₂₀O₂

CFN91619	Cannabidiol hydroxyquinone	137252-25-6	328.45	C₂₁H₂₈O₃
CFN99443	Epicannabidiol hydrate	139561-95-8	332.5	C₂₁H₃₂O₃
CFN99356	Cannabidiolic acid	1244-58-2	358.5	C₂₂H₃₀O₄
CFN91872	Delta-9-Tetrahydrocannabinolic acid	23978-85-0	358.47	C₂₂H₃₀O₄
CFN91898	Delta-9-Tetrahydrocannabinol	1972-08-3	314.46	C₂₁H₃₀O₂
CFN92993	Cannabinol	521-35-7	310.43	C₂₁H₂₆O₂