5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone | CAS:98187-98-5

5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone

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Product Name	5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone
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CAS No.:	98187-98-5
Catalog No.:	CFN92215
Molecular Formula:	C₁₈H₁₆O₈
Molecular Weight:	360.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The roots of Scutellaria baicalensis Georgi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone Description

Source:	The roots of Scutellaria baicalensis Georgi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Archives of Pharmacal Research,1987, 10 (4) :260-261.

Beziehung zwischen dem UV-Absorptionsmuster einiger Flavone und ihrer gegen L1210-Zellen cytotoxischen Aktivität[Reference: WebLink]

METHODS AND RESULTS:
The UV-pattern of several flavones, their cytotoxicities against L1210 cell and their Inhibiting effects on ATPase from the cell seem to be correlated. 5,2′-Dihydroxy-6,7,8,6′-tetramethoxyflavone (ED50=2.3 ug/ml) and 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED50=4.5 ug/ml), the most active flavones studied, have shown a narrow range of the absorbance ratio, Log εII/Log εI=1.073～1.109. They have inhibited the ATPase-activity to the greatest extent.
CONCLUSIONS:
These findings suggest that a certain angle between the flavone rings B and C plays an important role for the inhibition of the enzyme activity and thus the cytotoxicity.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Cytotoxic Compound Library Flavonoids Compound Library ATPase Inhibitor Library

Description:	5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED 50 =4.5 ug/ml ) shows cytotoxicity against L1210 cell and has inhibiting effects on ATPase from the cell.
Targets:	ATPase

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7755 mL	13.8773 mL	27.7546 mL	55.5093 mL	69.3866 mL
5 mM	0.5551 mL	2.7755 mL	5.5509 mL	11.1019 mL	13.8773 mL
10 mM	0.2775 mL	1.3877 mL	2.7755 mL	5.5509 mL	6.9387 mL
50 mM	0.0555 mL	0.2775 mL	0.5551 mL	1.1102 mL	1.3877 mL
100 mM	0.0278 mL	0.1388 mL	0.2775 mL	0.5551 mL	0.6939 mL

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CFN96498	Corymbosin	18103-41-8	358.34	C₁₉H₁₈O₇
CFN96510	Arteanoflavone	68710-17-8	374.35	C₁₉H₁₈O₈
CFN70332	3',4',5,5',6,7-Hexamethoxyflavone	29043-07-0	402.4	C₂₁H₂₂O₈
CFN95407	4'-Hydroxy-3',5,5',6,7,8-hexamethoxyflavone	85644-03-7	418.4	C₂₁H₂₂O₉
CFN91940	5'-Methoxynobiletin	6965-36-2	432.42	C₂₂H₂₄O₉
CFN97488	Viscidulin III	92519-91-0	346.3	C₁₇H₁₄O₈
CFN97545	Viscidulin III tetraacetate	96684-81-0	514.4	C₂₅H₂₂O₁₂
CFN92214	Viscidulin II	92519-93-2	330.3	C₁₇H₁₄O₇
CFN92215	5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone	98187-98-5	360.3	C₁₈H₁₆O₈