Crocin II | CAS:55750-84-0 | Manufacturer ChemFaces

Crocin II

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $48.4 / In-stock
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Description:

Crocin has antihyperlipidemic, antidepressant , anti-inflammatory and anti-apoptotic effects. It can reduce the protein expression of iNOS and caspase-3, and increase CREB, BDNF and VGF levels in hippocampus.

Targets:

NOS | Caspase

In vivo:

Braz.J.Pharm.Sci., 2015, 51(3):637-642

A preliminary study of the anti-inflammatory and anti-apoptotic effects of crocin against gastric ischemia-reperfusion injury in rats[Reference: WebLink]

The aim of the present study was to investigate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats.
METHODS AND RESULTS:
Thirty-two male rats were randomly divided into sham, I/R, I/R + crocin pretreatment and crocin alone groups. To induce I/R lesions, the celiac artery was clamped for 30 min, and the clamp was then removed to allow reperfusion for 3 h. Crocin-pretreated rats received crocin (15 mg/kg, i.p.) 30 min prior to the induction of I/R injury. Samples of gastric mucosa were collected to quantify the protein expression of caspase-3, an apoptotic factor, and inducible nitric oxide synthase (iNOS), a pro-inflammatory protein, by Western blot. Pretreatment with crocin decreased the total area of gastric lesions and decreased the protein expression levels of caspase-3 and iNOS induced by I/R injury.
CONCLUSIONS:
Our findings showed a protective effect of crocin in gastric mucosa against I/R injury. This effect of crocin was mainly mediated by reducing the protein expression of iNOS and caspase-3.

Crocin II Description

Source:	The stigma of Crocus sativus L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Biol Pharm Bull. 2005 Nov;28(11):2106-10.

Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin.[Pubmed: 16272698]

The pancreatic lipase inhibitors were isolated from the fructus of Gardenia jasminoides ELLIS, and their antihyperlipidemic activities were measured. Gardeniae fructus (GF) water extract inhibited pancreatic lipase activity.
METHODS AND RESULTS:
Crocetin and crocin were isolated from GF water extract as inhibitors of pancreatic lipase with an IC50 value of 2.1 and 2.6 mg/ml (triolein as a substrate). Crocin and crocetin significantly inhibited the increase of serum TG level in corn oil feeding-induced triglyceridemic mice, as well as that of serum triglyceride and total and LDL cholesterol levels in Triton WR-1339-induced hyperlipidemic mice. These compounds also showed hypolipidemic activity in hyperlipidemic mice induced by high cholesterol, high fat or high carbohydrate diets for 5 weeks.
CONCLUSIONS:
The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia.

Product Name	Crocin II
Price:	$118 / 20mg
CAS No.:	55750-84-0
Catalog No.:	CFN99928
Molecular Formula:	C₃₈H₅₄O₁₉
Molecular Weight:	814.83 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Dark red powder
Source:	The stigma of Crocus sativus L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Hepatoprotective Compound Library Anti-hyperlipidemic Compound Library Antidepressant Compound Library Anti-apoptotic Compound Library Diterpenoids Compound Library NOS Inhibitor Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2272 mL	6.1362 mL	12.2725 mL	24.545 mL	30.6812 mL
5 mM	0.2454 mL	1.2272 mL	2.4545 mL	4.909 mL	6.1362 mL
10 mM	0.1227 mL	0.6136 mL	1.2272 mL	2.4545 mL	3.0681 mL
50 mM	0.0245 mL	0.1227 mL	0.2454 mL	0.4909 mL	0.6136 mL
100 mM	0.0123 mL	0.0614 mL	0.1227 mL	0.2454 mL	0.3068 mL

CFN97734	Phytone	502-69-2	268.48	C₁₈H₃₆O
CFN99630	Phytol	150-86-7	296.5	C₂₀H₄₀O
CFN90226	Croceic acid	27876-94-4	328.40	C₂₀H₂₄O₄
CFN97516	Nemoralisin	942480-13-9	332.4	C₂₀H₂₈O₄
CFN90026	Retinoic acid	302-79-4	300.44	C₂₀H₂₈O₂
CFN93053	Acitretin	55079-83-9	326.43	C₂₁H₂₆O₃
CFN99927	Crocin I	94238-00-3	976.96	C₄₄H₆₄O₂₄
CFN99928	Crocin II	55750-84-0	814.83	C₃₈H₅₄O₁₉
CFN91597	Bixin	6983-79-5	394.5	C₂₅H₃₀O₄