6,7-Dihydroneridienone A | CAS:72959-46-7

6,7-Dihydroneridienone A

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Description:

6,7-Dihydroneridienone A exhibits notable leishmanicidal activity.

Targets:

Antifection

In vitro:

Planta Med 2012; 78 - PI239.

Compounds with antileishmanial activity isolated from the stems of Pentalinon andrieuxii.[Reference: WebLink]

METHODS AND RESULTS:
Bioassay-guided fractionation was conducted on a chloroform-soluble extract of the stems of Pentalinon andrieuxii, a Mayan traditional antileishmanial plant collected in a rainforest region of Mexico, using a Leishmania (L.) mexicana strain of parasites. This led to the isolation of five C21 sterol derivatives, neridienone A (1), 6,7-Dihydroneridienone A (2), cybisterol (3), 12β-hydroxypregn-4-ene-3,20-dione (4), and pentalinonoside (5), two coumarins, fraxidin (6) and fraxetol (7), as well as betulinic acid (8) and (+)-pinoresinol (9).
CONCLUSIONS:
All the isolates were evaluated in vitro for their ability to inhibit the growth of promastigotes of L. mexicana. Compounds 1-4, and 6 were found to exhibit notable leishmanicidal activity in this assay.

6,7-Dihydroneridienone A Description

Source:	The herbs of Tithonia diversifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	6,7-Dihydroneridienone A
Price:
CAS No.:	72959-46-7
Catalog No.:	CFN96120
Molecular Formula:	C₂₁H₂₈O₃
Molecular Weight:	328.5 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Tithonia diversifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-leishmanial Compound Library Steroids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0441 mL	15.2207 mL	30.4414 mL	60.8828 mL	76.1035 mL
5 mM	0.6088 mL	3.0441 mL	6.0883 mL	12.1766 mL	15.2207 mL
10 mM	0.3044 mL	1.5221 mL	3.0441 mL	6.0883 mL	7.6104 mL
50 mM	0.0609 mL	0.3044 mL	0.6088 mL	1.2177 mL	1.5221 mL
100 mM	0.0304 mL	0.1522 mL	0.3044 mL	0.6088 mL	0.761 mL

CFN99497	Pregnenolone	145-13-1	316.5	C₂₁H₃₂O₂
CFN90039	Progesterone	57-83-0	314.46	C₂₁H₃₀O₂
CFN96120	6,7-Dihydroneridienone A	72959-46-7	328.5	C₂₁H₂₈O₃
CFN90052	11Beta-hydroxyprogesterone	600-57-7	330.46	C₂₁H₃₀O₃
CFN90033	Hydrocortisone	50-23-7	362.46	C₂₁H₃₀O₅
CFN90044	Corticosterone	50-22-6	346.46	C₂₁H₃₀O₄
CFN97057	Neridienone B	61671-56-5	344.5	C₂₁H₂₈O₄
CFN97487	21-Deoxyneridienone B	924910-83-8	328.5	C₂₁H₂₈O₃