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6,7-Dihydroxyflavone
6,7-Dihydroxyflavone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 6,7-Dihydroxyflavone
Price: $118 / 20mg
CAS No.: 38183-04-9
Catalog No.: CFN70351
Molecular Formula: C15H10O4
Molecular Weight: 254.2 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Pueraria lobata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $34.9 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 6,7-Dihydroxyflavone has fee radical scavenging activity. 6,7-Dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA).
Targets: Antifection
In vitro:
Quantitative Structure Activity Relationships, 2000, 19(1):50-53.
Theoretical Investigation on Free Radical Scavenging Activity of 6,7‐Dihydroxyflavone.[Reference: WebLink]

METHODS AND RESULTS:
The difference of heat of formation between parent molecule and its free radical (ΔHOF), calculated by semiempirical quantum chemical method AM1, was employed as a theoretical index to characterize the O–H bond dissociation energy (BDE) of antioxidant. Through a comparison between ΔHOF of model molecules, it was found that 6,7‐dihydroxyflavone (DHF) possessed two favorable structural factors, the presence of ortho hydroxyls and the existence of para oxygen, to weaken its O–H bond at position 6, but the passive effect produced by electron‐withdrawing property of the chromonoid ring C surpassed the active effect of the para oxygen. Therefore the free radical scavenging activity of DHF was lower than that of quercetin which possessed catecholic hydroxyl in ring B and was scarcely influenced by ring C.
CONCLUSIONS:
As a result of the analysis, two more active flavonoid antioxidants were constructed theoretically.
Antimicrobial Agents and Chemotherapy, 01 Apr 2004, 48(4):1357-1360.
6,7-Dihydroxyflavone Dramatically Intensifies the Susceptibility of Methicillin-Resistant or -Sensitive Staphylococcus aureus to -Lactams.[Reference: WebLink]

METHODS AND RESULTS:
We have demonstrated that 6,7-Dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to beta-lactam antibiotics from 8- to 32,800-fold.
6,7-Dihydroxyflavone Description
Source: The roots of Pueraria lobata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9339 mL 19.6696 mL 39.3391 mL 78.6782 mL 98.3478 mL
5 mM 0.7868 mL 3.9339 mL 7.8678 mL 15.7356 mL 19.6696 mL
10 mM 0.3934 mL 1.967 mL 3.9339 mL 7.8678 mL 9.8348 mL
50 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.5736 mL 1.967 mL
100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.7868 mL 0.9835 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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Lanosterol

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CAS No: 79-63-0
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