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6-Deoxyisojacareubin
6-Deoxyisojacareubin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 6-Deoxyisojacareubin
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CAS No.: 26486-92-0
Catalog No.: CFN89446
Molecular Formula: C18H14O5
Molecular Weight: 310.30 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Powder
Source: The stem-barks of Garcinia nervosa.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibition of protein kinase C (PKC).
Targets: PKC | Antifection
In vitro:
Arch Pharm (Weinheim). 2013 Apr;346(4):314-20.
Efficient total synthesis and biological activities of 6-deoxyisojacareubin.[Pubmed: 23519477 ]

METHODS AND RESULTS:
6-Deoxyisojacareubin was directly synthesized in a six-step route with an overall yield of about 20%. In this route, the excellent site selectivity of this Claisen rearrangement-cyclization reaction cascade was achieved by inserting a bulky p-tosyl group into the free 1-OH, and in the last step, some efficient demethylation methods were explored. Furthermore, all synthesized intermediates including 6-Deoxyisojacareubin were evaluated for their inhibitory activity against the QGY-7703 cell line.
CONCLUSIONS:
Of these, compound 1 and 6-Deoxyisojacareubin showed moderate activities with IC50 values of 39.61 and 9.65 μM, respectively, when compared to the positive control 5-fluorouracil with an IC50 value of 11.24 μM. Further investigation using non-radioactive detection of protein kinase C (PKC) suggested that these two compounds possessed potency in the inhibition of PKC.
6-Deoxyisojacareubin Description
Source: The stem-barks of Garcinia nervosa.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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IF=12.804(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2227 mL 16.1134 mL 32.2269 mL 64.4538 mL 80.5672 mL
5 mM 0.6445 mL 3.2227 mL 6.4454 mL 12.8908 mL 16.1134 mL
10 mM 0.3223 mL 1.6113 mL 3.2227 mL 6.4454 mL 8.0567 mL
50 mM 0.0645 mL 0.3223 mL 0.6445 mL 1.2891 mL 1.6113 mL
100 mM 0.0322 mL 0.1611 mL 0.3223 mL 0.6445 mL 0.8057 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Res. 2017 Nov;31(21):2513-2519.
A new pyranoxanthone from Garcinia nervosa.[Pubmed: 28412841]

METHODS AND RESULTS:
Phytochemical studies on the stem bark of Garcinia nervosa has resulted in the discovery of one new pyranoxanthone derivative, garner xanthone (1) and five other compounds, 1,5-dihydroxyxanthone (2), 6-Deoxyisojacareubin (3), 12b-hydroxy-des-D-garcigerrin A (4) stigmasterol (5), and β-sitosterol (6). The structures of these compounds were elucidated with the aid of spectroscopic techniques, such as NMR and MS.
CONCLUSIONS:
The crude extracts of the plant were assessed for their antimicrobial activity.
CFN988911,3,5-Trihydroxy-4-prenylxanthone53377-61-0312.3 C18H16O5
CFN894466-Deoxyisojacareubin26486-92-0310.30C18H14O5
CFN96469Ugaxanthone13179-11-8328.32C18H16O6
CFN96573Isojacareubin50597-93-8326.31C18H14O6
CFN925411,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one1319198-98-5328.3C18H16O6
CFN962766-Deoxyjacareubin16265-56-8310.3C18H14O5
CFN980221,3,7-Trihydroxy-2-prenylxanthone20245-39-0312.3 C18H16O5
CFN972641,7-Dihydroxy-3-methoxy-2-prenylxanthone77741-58-3326.4 C19H18O5
CFN992021,5,8-Trihydroxy-3-methoxy-2-prenylxanthone110187-11-6342.4 C19H18O6
CFN990161,4,5,6-Tetrahydroxy-7-prenylxanthone1001424-68-5328.3 C18H16O6
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