6-Deoxyisojacareubin | CAS:26486-92-0 | Manufacturer ChemFaces

6-Deoxyisojacareubin

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Description:

6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibition of protein kinase C (PKC).

Targets:

PKC | Antifection

In vitro:

Arch Pharm (Weinheim). 2013 Apr;346(4):314-20.

Efficient total synthesis and biological activities of 6-deoxyisojacareubin.[Pubmed: 23519477 ]

METHODS AND RESULTS:
6-Deoxyisojacareubin was directly synthesized in a six-step route with an overall yield of about 20%. In this route, the excellent site selectivity of this Claisen rearrangement-cyclization reaction cascade was achieved by inserting a bulky p-tosyl group into the free 1-OH, and in the last step, some efficient demethylation methods were explored. Furthermore, all synthesized intermediates including 6-Deoxyisojacareubin were evaluated for their inhibitory activity against the QGY-7703 cell line.
CONCLUSIONS:
Of these, compound 1 and 6-Deoxyisojacareubin showed moderate activities with IC50 values of 39.61 and 9.65 μM, respectively, when compared to the positive control 5-fluorouracil with an IC50 value of 11.24 μM. Further investigation using non-radioactive detection of protein kinase C (PKC) suggested that these two compounds possessed potency in the inhibition of PKC.

6-Deoxyisojacareubin Description

Source:	The stem-barks of Garcinia nervosa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	6-Deoxyisojacareubin
Price:
CAS No.:	26486-92-0
Catalog No.:	CFN89446
Molecular Formula:	C₁₈H₁₄O₅
Molecular Weight:	310.30 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Powder
Source:	The stem-barks of Garcinia nervosa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Antibacterial Compound Library Xanthones Compound Library PKC Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2227 mL	16.1134 mL	32.2269 mL	64.4538 mL	80.5672 mL
5 mM	0.6445 mL	3.2227 mL	6.4454 mL	12.8908 mL	16.1134 mL
10 mM	0.3223 mL	1.6113 mL	3.2227 mL	6.4454 mL	8.0567 mL
50 mM	0.0645 mL	0.3223 mL	0.6445 mL	1.2891 mL	1.6113 mL
100 mM	0.0322 mL	0.1611 mL	0.3223 mL	0.6445 mL	0.8057 mL

CFN99675	1,4,6-Trihydroxy-5-methoxy-7-prenylxanthone	160623-47-2	342.4	C₁₉H₁₈O₆
CFN97493	O-Demethylforbexanthone	92609-77-3	326.3	C₁₈H₁₄O₆
CFN91900	Hyperxanthone E	819860-76-9	328.32	C₁₈H₁₆O₆
CFN99206	Garcinexanthone A	1107620-67-6	342.4	C₁₉H₁₈O₆
CFN95802	Garcinexanthone C	1107620-69-8	328.3	C₁₈H₁₆O₆
CFN89056	7-Prenyljacareubin	94513-60-7	394.42	C₂₃H₂₂O₆
CFN89137	Pyranojacareubin	78343-62-1	392.40	C₂₃H₂₀O₆
CFN98891	1,3,5-Trihydroxy-4-prenylxanthone	53377-61-0	312.3	C₁₈H₁₆O₅
CFN89446	6-Deoxyisojacareubin	26486-92-0	310.30	C₁₈H₁₄O₅
CFN96469	Ugaxanthone	13179-11-8	328.32	C₁₈H₁₆O₆