7-Oxo-ganoderic acid Z | CAS:929248-72-6

7-Oxo-ganoderic acid Z

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Description:

7-Oxo-ganoderic acid Z shows strong inhibitory effects against α-glucosidase, it also exhibits inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase. 7-Oxo-ganoderic acid Z can reduce cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 uM.

Targets:

HMG-CoA Reductase

In vitro:

Phytochemistry. 2018 May;149:103-115.

Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase.[Pubmed: 29490285 ]

Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time.
METHODS AND RESULTS:
The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-Oxo-ganoderic acid Z3, 7-Oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose.
CONCLUSIONS:
The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes.

7-Oxo-ganoderic acid Z Description

Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	7-Oxo-ganoderic acid Z
Price:
CAS No.:	929248-72-6
Catalog No.:	CFN92998
Molecular Formula:	C₃₀H₄₆O₄
Molecular Weight:	470.68 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library HMG-CoA Reductase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1246 mL	10.6229 mL	21.2459 mL	42.4917 mL	53.1146 mL
5 mM	0.4249 mL	2.1246 mL	4.2492 mL	8.4983 mL	10.6229 mL
10 mM	0.2125 mL	1.0623 mL	2.1246 mL	4.2492 mL	5.3115 mL
50 mM	0.0425 mL	0.2125 mL	0.4249 mL	0.8498 mL	1.0623 mL
100 mM	0.0212 mL	0.1062 mL	0.2125 mL	0.4249 mL	0.5311 mL

CFN95538	New compound 19	N/A	554.7	C₃₂H₄₂O₈
CFN95518	Ganoderic acid GS-3	1206781-66-9	558.7	C₃₂H₄₆O₈
CFN95591	Resinacein D	2231061-47-3	486.7	C₃₀H₄₆O₅
CFN95592	11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid	1245703-70-1	484.7	C₃₀H₄₄O₅
CFN95536	Ganolucidic acid E	114567-50-9	484.7	C₃₀H₄₄O₅
CFN95570	New compound 22	N/A	500.7	C₃₀H₄₄O₆
CFN95537	Ganoderic acid beta	217476-76-1	500.7	C₃₀H₄₄O₆
CFN95571	Ganoderic acid GS-1	1206781-64-7	498.7	C₃₀H₄₂O₆
CFN95549	Ganoderic acid GS-2	1206781-65-8	500.7	C₃₀H₄₄O₆
CFN95560	New compound 21	N/A	514.7	C₃₀H₄₂O₇