5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) | CAS:79559-61-8

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)

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Product Name	5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)
Price:	$268 / 20mg
CAS No.:	79559-61-8
Catalog No.:	CFN95135
Molecular Formula:	C₂₀H₂₄O₄
Molecular Weight:	328.4 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The rhizomes of Curcuma longa L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $96.2 / In-stock
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Description:

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity.

In vitro:

Biol Pharm Bull. 2004 Jan;27(1):138-40.

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone: a pancreatic lipase inhibitor isolated from Alpinia officinarum.[Pubmed: 14709919 ]

METHODS AND RESULTS:
A pancreatic lipase inhibitor, 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (HPH)[5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) ], from the rhizome of Alpinia officinarum (AO) was isolated and its antihyperlipidemic activity was measured. HPH inhibited a pancreatic lipase with an IC(50) value of 1.5 mg/ml (triolein as a substrate). HPH significantly lowered the serum TG level in corn oil feeding-induced triglyceridemic mice, and reduced serum triglyceride (TG) and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, HPH did not show hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice.
CONCLUSIONS:
Based on these findings, we propose that PL inhibitors may be effective as hypolipidemic agents.

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) Description

Source:	The rhizomes of Curcuma longa L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0451 mL	15.2253 mL	30.4507 mL	60.9013 mL	76.1267 mL
5 mM	0.609 mL	3.0451 mL	6.0901 mL	12.1803 mL	15.2253 mL
10 mM	0.3045 mL	1.5225 mL	3.0451 mL	6.0901 mL	7.6127 mL
50 mM	0.0609 mL	0.3045 mL	0.609 mL	1.218 mL	1.5225 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.609 mL	0.7613 mL

CFN95195	(3S,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol	87095-75-8	282.4	C₁₉H₂₂O₂
CFN95227	(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol	232261-31-3	282.4	C₁₉H₂₂O₂
CFN97433	5-Hydroxy-1,7-diphenyl-6-hepten-3-one	87095-74-7	280.4	C₁₉H₂₀O₂
CFN95135	5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)	79559-61-8	328.4	C₂₀H₂₄O₄
CFN95602	Oxyphyllacinol	87657-77-0	314.4	C₂₀H₂₆O₃
CFN95555	Yakuchinone A	78954-23-1	312.4	C₂₀H₂₄O₃
CFN92686	Alpinoid D	1041740-13-9	308.4	C₂₀H₂₀O₃
CFN92257	Daphnenone	936006-13-2	252.3	C₁₇H₁₆O₂
CFN92628	3-Hydroxy-1,5-diphenyl-1-pentanone	60669-64-9	254.3	C₁₇H₁₈O₂
CFN92258	Daphneolone	54835-64-2	270.3	C₁₇H₁₈O₃