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Aburatubolactam A
Aburatubolactam A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Aburatubolactam A
Price:
CAS No.: 170894-24-3
Catalog No.: CFN00101
Molecular Formula: C30H40N2O5
Molecular Weight: 508.66 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source: From Streptomyces sp.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Aburatubolactam A is an inhibitor of superoxide anion generation. It has demonstrated cytotoxic activity against P388 murine leukemia cell lines (IC50 = 26 ug/mL) and inhibits TPA-induced superoxide anion generation by human neutrophils; enhanced levels of superoxide anion is thought to be closely related to inflammation, cancer, and aging.
Targets: Immunology & Inflammation related
In vitro:
Dissertations & Theses - Gradworks, 2008,3308674.
Synthesis of marine natural products: Aburatubolactam A and the halichondrins.[Reference: WebLink]
Aburatubolactam A is a tetramic acid macrolactam isolated by Uemura and coworkers in 1996 from the cultured broth of a sp., SCRC-A20, taken from the surface of a mollusk collected on the seashore near Aburatubo, Kanagawa Prefecture, Japan.
METHODS AND RESULTS:
Aburatubolactam A has demonstrated cytotoxic activity against P388 murine leukemia cell lines (IC= 26 ug/mL) and inhibits TPA-induced superoxide anion generation by human neutrophils. Enhanced levels of superoxide anion is thought to be closely related to inflammation, cancer, and aging. Unfortunately, inadequate quantities of material were isolated to allow broader testing.
Aburatubolactam A Description
Source: From Streptomyces sp.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9659 mL 9.8297 mL 19.6595 mL 39.319 mL 49.1487 mL
5 mM 0.3932 mL 1.9659 mL 3.9319 mL 7.8638 mL 9.8297 mL
10 mM 0.1966 mL 0.983 mL 1.9659 mL 3.9319 mL 4.9149 mL
50 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.7864 mL 0.983 mL
100 mM 0.0197 mL 0.0983 mL 0.1966 mL 0.3932 mL 0.4915 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Heterocyclic Communications, 1996, 2(4):315-8.
Aburatubolactam A, a novel inhibitor of superoxide anion generation from a marine microorganism.[Reference: WebLink]
Aburatubolactam A (1), isolated from the cultured broth of a Streptomyces sp., SCRC-A20, separated from a mollusk, potently inhibited superoxide anion generation. The structure of Aburatubolactam A was determined by X-ray crystallographic analysis and the complete assignment of the resonances in the 1H-NMR spectrum was achieved.
CFN00090Panamycin 607100905-89-3607.86C35H61NO7
CFN00101Aburatubolactam A170894-24-3508.66C30H40N2O5
CFN00103Altamycin A60202-22-4561.67C30H43NO9
CFN00112Cylindramide147362-39-8466.57C27H34N2O5
CFN00114Discodermide134458-00-7482.58C27H34N2O6
CFN00126Antibiotic BU 2313A69774-86-3517.57C27H35NO9
CFN00144Xanthobaccin A227596-81-8510.63C29H38N2O6
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