Mahuannin B | CAS:82796-37-0 | Manufacturer ChemFaces

Mahuannin B

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $365.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Mahuannin B Description

Source:	The herbs of Ephedra spp.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Phytomedicine . 2017 Jul 1;30:18-27.

Mahuannin B an adenylate cyclase inhibitor attenuates hyperhidrosis via suppressing β2-adrenoceptor/cAMP signaling pathway[Pubmed: 28545666]

Background: Based on the traditional application of traditional Chinese Medicines (TCMs), Ephedra Herba (EH) is used to cure cold fever by inducing sweating, whereas Ephedra Radix (ER) is used to treat hyperhidrosis. Although they come from the same plant, Ephedra sinica Stapf, but have play opposing roles in clinical applications. EH is known to contain ephedrine alkaloids, which is the driver of the physiological changes in sweating, heart rate and blood pressure. However, the active pharmacological ingredients (APIs) of ER and the mechanisms by which it restricts sweating remain unknown. Purpose: The current work aims to discover the hidroschesis APIs from ER, as well as to establish its action mechanism. Methods: UPLC-Q/TOF-MS, PCA, and heat map were utilized for identifying the differences between EH and ER. HPLC integrated with a β2-adrenoceptor (β2-AR) activity luciferase reporter assay system was used to screen active inhibitors; molecular docking and a series of biological assays centered on β2-AR-related signaling pathways were evaluated to understand the roles of APIs. Results: The opposite effect on sweating of EH and ER can be attributed to the APIs of amphetamine-type alkaloids and flavonoid derivatives. Mahuannin B is an effective anti-hydrotic agent, inhibiting the production of cAMP via suppression of adenylate cyclase (AC) activity. Conclusion: The effects of EH and ER on sweat and β2-AR-related signaling pathway are opposite due to different alkaloids and flavonoids of APIs in EH and ER. The present work not only sheds light on the hidroschesis action of Mahuannin B, but also presents a potential target of AC in the treatment of hyperhidrosis.

Product Name	Mahuannin B
Price:	$318 / 5mg
CAS No.:	82796-37-0
Catalog No.:	CFN95554
Molecular Formula:	C₃₀H₂₄O₁₀
Molecular Weight:	544.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Ephedra spp.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8365 mL	9.1827 mL	18.3655 mL	36.7309 mL	45.9137 mL
5 mM	0.3673 mL	1.8365 mL	3.6731 mL	7.3462 mL	9.1827 mL
10 mM	0.1837 mL	0.9183 mL	1.8365 mL	3.6731 mL	4.5914 mL
50 mM	0.0367 mL	0.1837 mL	0.3673 mL	0.7346 mL	0.9183 mL
100 mM	0.0184 mL	0.0918 mL	0.1837 mL	0.3673 mL	0.4591 mL

CFN95547	Ephedrannin D1	1592431-55-4	592.5	C₃₀H₂₄O₁₃
CFN95801	Aesculitannin B	114612-77-0	864.8	C₄₅H₃₆O₁₈
CFN95451	Dehydrodicatechin A	36048-23-4	576.5	C₃₀H₂₄O₁₂
CFN92679	Dracoflavan C2	194794-50-8	522.6	C₃₃H₃₀O₆
CFN92680	Dracoflavan C1	194794-49-5	522.6	C₃₃H₃₀O₆
CFN92682	Dracoflavan B1	194794-44-0	538.6	C₃₃H₃₀O₇
CFN92683	Dracoflavan B2	194794-47-3	538.6	C₃₃H₃₀O₇
CFN91960	Stelleranol	795308-62-2	558.49	C₃₀H₂₂O₁₁
CFN91961	Genkwanol B	142674-67-7	558.49	C₃₀H₂₂O₁₁
CFN91962	Genkwanol C	151283-11-3	558.49	C₃₀H₂₂O₁₁