Agrimol B | CAS:55576-66-4 | Manufacturer ChemFaces

Agrimol B

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Description:

Agrimol B has antibacterial activity against Pseudomonas syringae pv. lacrymans (bacterial leaf spot pathogen), Ralstonia solanacearum (tomato bacterial wilt pathogen) and Pseudomonas syringae pv. tabaci (Tobacco wild fire pathogen). Agrimol B has a therapeutic potential on alleviating obesity, through modulation of SIRT1-PPARγ signal pathway.

Targets:

PPAR | Antifection

In vitro:

The Korean Journal of Pesticide Science,2006, 10(3):230-6.

Antibacterial Activities against Plant Pathogens and Identification of Agrimol B from Agrimonia pilosa LEDEB.[Reference: WebLink]

METHODS AND RESULTS:
Eighty-five percent methanol extract of Agrimonia pilosa has antibacterial activity against Pseudomonas syringae pv. lacrymans (bacterial leaf spot pathogen), Ralstonia solanacearum (tomato bacterial wilt pathogen) and Pseudomonas syringae pv. tabaci (Tobacco wild fire pathogen.). The active substance was purified by silica gel column chromatography and HPLC. The molecular weight of the active compound was determined by LC-Mass as 687.2.
CONCLUSIONS:
With NMR analysis, the active substance was identified as Agrimol B.

Biochem Biophys Res Commun . 2016 Aug 26;477(3):454-60.

Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway[Pubmed: 27320865]

Abstract Studies of human genetics have implicated the role of SIRT1 in regulating obesity, insulin resistance, and longevity. These researches motivated the identification of novel SIRT1 activators. The current study aimed to investigate the potential efficacy of Agrimol B, a polyphenol derived from Agrimonia pilosa Ledeb., on mediating SIRT1 activity and fat metabolism. Results showed that Agrimol B significantly induced cytoplasm-to-nucleus shuttle of SIRT1. Furthermore, we confirmed that Agrimol B dramatically inhibited 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. Consequently, adipogenesis was blocked by treatment of Agrimol B at the early stage of differentiation in a dose-dependent manner, the IC50 value was determined as 3.35 ± 0.32 μM. Taken together, our data suggest a therapeutic potential of Agrimol B on alleviating obesity, through modulation of SIRT1-PPARγ signal pathway. Keywords: Agrimol B; Agrimonia pilosa Ledeb.; Lipid droplet; Obesity; PPARγ; SIRT1.

Agrimol B Description

Source:	The herbs of Agrimonia pilosa Ledeb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60.

Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway.[Pubmed: 27320865]

Studies of human genetics have implicated the role of SIRT1 in regulating obesity, insulin resistance, and longevity. These researches motivated the identification of novel SIRT1 activators.
METHODS AND RESULTS:
The current study aimed to investigate the potential efficacy of Agrimol B, a polyphenol derived from Agrimonia pilosa Ledeb., on mediating SIRT1 activity and fat metabolism. Results showed that Agrimol B significantly induced cytoplasm-to-nucleus shuttle of SIRT1. Furthermore, we confirmed that Agrimol B dramatically inhibited 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. Consequently, adipogenesis was blocked by treatment of Agrimol B at the early stage of differentiation in a dose-dependent manner, the IC50 value was determined as 3.35 ± 0.32 μM.
CONCLUSIONS:
Taken together, our data suggest a therapeutic potential of Agrimol B on alleviating obesity, through modulation of SIRT1-PPARγ signal pathway.

Structure Identification:

Biomed Chromatogr. 2015 Apr;29(4):481-4.

Development of a liquid chromatography-mass spectrometry method for determination of agrimol B in rat plasma: application to preclinical pharmacokinetics.[Pubmed: 25065576]

A sensitive and accurate liquid chromatography coupled with mass spectrometry (LC-MS) method was developed for the determination of Agrimol B, a main active ingredient isolated from Agrimonia pilosa Ledeb., in rat plasma.
METHODS AND RESULTS:
Chromatographic separation was achieved on a Zorbax CN column (150 × 4.6 mm, 5 µm), with isocratic elution consisting of acetonitrile and water (15:85, v/v) at a flow rate of 0.6 mL/min. Agrimol B and dryocrassin ABBA, an internal standard (IS), were analyzed by selected ion monitoring at m/z transitions of 681.3 and 819.4, respectively. This assay exhibited a good linearity with a correlation coefficient >0.99 and showed no endogenous interference with the analyte and IS. The limit of quantification of Agrimol B was 8.025 ng/mL with acceptable precision and accuracy. The method was successfully applied in the pharmacokinetic study of Agrimol B in rats after intravenous (1 mg/kg) and oral (2, 5 and 10 mg/kg) doses of Agrimol B. The absolute bioavailability of Agrimol B was 16.4-18.0% in rat.
CONCLUSIONS:
Our study clarifies the pharmacokinetic behavior of Agrimol B in animals.

Product Name	Agrimol B
Price:	$138 / 20mg
CAS No.:	55576-66-4
Catalog No.:	CFN98169
Molecular Formula:	C₃₇H₄₆O₁₂
Molecular Weight:	682.75 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Agrimonia pilosa Ledeb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Anti-obesity Compound Library Phenols Compound Library PPAR Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4647 mL	7.3233 mL	14.6466 mL	29.2933 mL	36.6166 mL
5 mM	0.2929 mL	1.4647 mL	2.9293 mL	5.8587 mL	7.3233 mL
10 mM	0.1465 mL	0.7323 mL	1.4647 mL	2.9293 mL	3.6617 mL
50 mM	0.0293 mL	0.1465 mL	0.2929 mL	0.5859 mL	0.7323 mL
100 mM	0.0146 mL	0.0732 mL	0.1465 mL	0.2929 mL	0.3662 mL

CFN92877	Didemethylpseudoaspidin AA	142382-28-3	376.4	C₁₉H₂₀O₈
CFN90684	Pseudoaspidin	478-28-4	460.5	C₂₅H₃₂O₈
CFN98474	Albaspidin AA	3570-40-9	404.4	C₂₁H₂₄O₈
CFN90252	Albaspidin AP	59092-91-0	418.44	C₂₂H₂₆O₈
CFN99573	Filixic acid ABA	38226-84-5	612.63	C₃₂H₃₆O₁₂
CFN98169	Agrimol B	55576-66-4	682.75	C₃₇H₄₆O₁₂
CFN99519	Dryocrassin ABBA	12777-70-7	820.81	C₄₃H₄₈O₁₆
CFN90561	Gossypol	303-45-7	518.56	C₃₀H₃₀O₈
CFN98529	Acetate gossypol	12542-36-8	578.61	C₃₂H₃₄O₁₀
CFN99601	Sideroxylonal A	145382-68-9	500.5	C₂₆H₂₈O₁₀