Alpinone 3-acetate | CAS:139906-49-3 | Manufacturer ChemFaces

Alpinone 3-acetate

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Description:

Alpinone 3-acetate has anti-inflammatory activity, it can inhibit 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation in a mouse model of ear edema.

Targets:

Immunology & Inflammation related

In vivo:

J Nat Med. 2016 Jul;70(3):653-60.

Anti-inflammatory effects of alpinone 3-acetate from Alpinia japonica seeds.[Pubmed: 27137785]

We aimed to investigate the bioactive components of Alpinia japonica as anti-inflammatory compounds using searches of the Alpinia genus, and subsequently demonstrated that Alpinone 3-acetate markedly inhibits 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation in a mouse model of ear edema.
METHODS AND RESULTS:
To assess other bioactivities of Alpinone 3-acetate, we performed translatome analyses and compared them with those of hydrocortisone. Polysome-associated mRNAs were prepared from Alpinone 3-acetate- or hydrocortisone-treated and control cells from 12-O-tetradecanoyiphorbol 13-acetate-induced THP-1-derived macrophages cultured in the presence of Escherichia coli O-111 lipopolysaccharide. Subsequent microarray analysis revealed that Alpinone 3-acetate and hydrocortisone upregulated and downregulated the same 155 and 41 genes, respectively. Moreover, direct comparisons of translationally regulated genes indicated 5 and 10 gene probes that were upregulated and downregulated by Alpinone 3-acetate and hydrocortisone, respectively.
CONCLUSIONS:
In conclusion, assays of 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation ear edema in mice and polysome profiling of Alpinone 3-acetate bioactivities indicated similar medicinal possibilities to those of hydrocortisone.

Alpinone 3-acetate Description

Source:	The seeds of Alpinia japonica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Alpinone 3-acetate
Price:
CAS No.:	139906-49-3
Catalog No.:	CFN89493
Molecular Formula:	C₁₈H₁₆O₆
Molecular Weight:	328.31 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The seeds of Alpinia japonica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Flavonoids Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0459 mL	15.2295 mL	30.459 mL	60.918 mL	76.1475 mL
5 mM	0.6092 mL	3.0459 mL	6.0918 mL	12.1836 mL	15.2295 mL
10 mM	0.3046 mL	1.523 mL	3.0459 mL	6.0918 mL	7.6148 mL
50 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.2184 mL	1.523 mL
100 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.6092 mL	0.7615 mL

CFN98917	Pinobanksin	548-82-3	272.3	C₁₅H₁₂O₅
CFN98845	3-O-Acetylpinobanksin	52117-69-8	314.3	C₁₇H₁₄O₆
CFN89460	Pinobanksin 3-O-propanoate	126394-70-5	328.31	C₁₈H₁₆O₆
CFN99051	3,7-O-Diacetylpinobanksin	103553-98-6	356.3	C₁₉H₁₆O₇
CFN89500	Pinobanksin 5-methyl ether	119309-36-3	286.27	C₁₆H₁₄O₅
CFN89493	Alpinone 3-acetate	139906-49-3	328.31	C₁₈H₁₆O₆