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Angoline
Angoline
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Angoline
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CAS No.: 21080-31-9
Catalog No.: CFN91469
Molecular Formula: C22H21NO5
Molecular Weight: 379.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Hylomecon hylomeconoides.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Our products had been exported to the following research institutions and universities, And still growing.
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  • Aveiro University (Portugal)
  • Chungnam National University (Korea)
  • Auburn University (USA)
  • Sanford Burnham Prebys Medical ... (USA)
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  • Universidad Miguel Hernández (Spain)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation IC50 & Target;IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)
Angoline Description
Source: The herbs of Hylomecon hylomeconoides.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6357 mL 13.1787 mL 26.3574 mL 52.7148 mL 65.8935 mL
5 mM 0.5271 mL 2.6357 mL 5.2715 mL 10.543 mL 13.1787 mL
10 mM 0.2636 mL 1.3179 mL 2.6357 mL 5.2715 mL 6.5894 mL
50 mM 0.0527 mL 0.2636 mL 0.5271 mL 1.0543 mL 1.3179 mL
100 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.5271 mL 0.6589 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN90127Dihydrochelerythrine6880-91-7349.38C21H19NO4
CFN92737Norchelerythrine6900-99-8333.3C20H15NO4
CFN97999Oxychelerythrine28342-33-8363.4C21H17NO5
CFN98909Decarine54354-62-0319.3 C19H13NO4
CFN98109Nitidine chloride13063-04-2383.83C21H18ClNO4
CFN98259Sanguinarine2447-54-3332.3 C20H14NO4
CFN92810Dihydrosanguinarine3606-45-9333.1C20H15NO4
CFN892996-Methoxydihydrosanguinarine72401-54-8363.36C21H17NO5
CFN893086-Ethoxydihydrosanguinarine28342-31-6377.39C22H19NO5
CFN91469Angoline21080-31-9379.4C22H21NO5
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