| In vitro: |
| Journal of Shanghai Medica, 2005, 32(4):467-70. | | Effects of heteroclitin D, schisanhenol and ( + )-anwulignan on platelet aggregation.[Reference: WebLink] |
To investigate the effects of three lignans: heteroclitin D (HD), schisanhenol (SAL) and ( + )-Anwulignan(AN) with different skeletons from Schisandraceae medicinal plants on platelet aggregation.
METHODS AND RESULTS:
At concentrations 0.05-25 mg/L of the three lignans, rabbit platelet aggregation induced by adenosine diphosphate (ADP) and platelet activating factor(PAF) were studied by Born's turbidimetry, the maximum time of platelet aggregation and platelet aggregation at 1,3,5 min were also observed. 1 HD and SAL inhibited the ADP- and PAF-induced platelet aggregation in a concentration-dependant manner. The inhibitory effect of AN was weak. 2 ADP-induced platelet aggregation at 1, 3,5 min were inhibited by HD and SAL in a similar manner. At 5 mg/L,AN inhibited platelet aggregation at 3 and 5 min significantly;The PAF-induced platelet aggregation at 1,3,5 min, the inhibition of HD at 1,3 min and of SAL at 3,5 min were more potent. 3 HD, SAL and AN had no effects on maximum time of ADP- and PAF-induced platelet aggregation.
CONCLUSIONS:
HD,SAL and AN have inhibitory effects on platelets aggregation induced by ADP and PAF in vitro. The inhibitory effect of HD is the most potent and could be one of the important active components from Kadsura medicinal plants. |
|
| In vivo: |
| Chin Med . 2011 Mar 4;6:10. | | Effects of a multi-herbal extract on type 2 diabetes[Pubmed: 21375727] | | Abstract
Background: An aqueous extract of multi-hypoglycemic herbs of Panax ginseng C.A.Meyer, Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus and Evodia officinalis was investigated for its anti-diabetic effects in cell and animal models.
Methods: Activities of PPARγ agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in db/db mice (a genetic animal model for type 2 diabetes).
Results: While the extract stimulated PPARγ-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-α-stimulated IKKβ/NFkB signaling and attenuated ER stress in HepG2 cells. The db/db mice treated with the extract showed reduced fasting blood glucose and HbA1c levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol.
Conclusion: The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models. |
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