Science | Nature | Cell | View More
Natural Products
Aromadendrin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Aromadendrin
Price: $318 / 20mg
CAS No.: 480-20-6
Catalog No.: CFN98736
Molecular Formula: C15H12O6
Molecular Weight: 288.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The barks of Eucalyptus calophylla
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $52.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Charles Sturt University (Denmark)
  • Semmelweis Unicersity (Hungary)
  • University of Parma (Italy)
  • University of Auckland (New Zealand)
  • Julius Kühn-Institut (Germany)
  • University of Mysore (India)
  • National Cancer Institute (USA)
  • University of Maryland School o... (USA)
  • St. Jude Children Research Hosp... (USA)
  • Rio de Janeiro State University (Brazil)
  • Tohoku University (Japan)
  • More...
Package
Featured Products
trans-3-Hydroxycinnamic acid

Catalog No: CFN98181
CAS No: 14755-02-3
Price: $30/20mg
Pimaric acid

Catalog No: CFN99382
CAS No: 127-27-5
Price: $ /
Pelargonidin chloride

Catalog No: CFN92132
CAS No: 134-04-3
Price: $318/10mg
Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg
Saponarin

Catalog No: CFN90134
CAS No: 20310-89-8
Price: $288/10mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Daidzein

Catalog No: CFN98774
CAS No: 486-66-8
Price: $30/20mg
Syringetin

Catalog No: CFN70363
CAS No: 4423-37-4
Price: $ / mg
Astrasieversianin VII

Catalog No: CFN90648
CAS No: 86764-11-6
Price: $238/10mg
Juglone

Catalog No: CFN90497
CAS No: 481-39-0
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells. Aromadendrin treatment induces adipogenesis by increases in PPARγ2 expression, resulting in stimulation of glucose uptake and ameliorated insulin resistance, suggests that it may represent a potential therapeutic candidate for the management of type 2 DM. Aromadendrin has inhibitory activity on aldose reductase and the formation of advanced glycation end products.
Targets: NO | PGE | NOS | COX | NF-kB | JNK | ERK | p38MAPK | PPAR | PI3K | Akt | IkB | IKK
In vitro:
Pharmacology. 2011;88(5-6):266-74.
Stimulation of glucose uptake and improvement of insulin resistance by aromadendrin.[Pubmed: 22056597]
Agents that stimulate glucose uptake and improve insulin resistance may be useful in the management of type 2 diabetes mellitus (DM). Thus, the aims of this study were to assess the effects of Aromadendrin, a flavonoid from Gleditsia sinensis Lam., on stimulation of glucose uptake and improvement of insulin resistance and to characterize the molecular mechanisms underlying these activities.
METHODS AND RESULTS:
Insulin-stimulated glucose uptake was measured in HepG2 cells and in differentiated 3T3-L1 adipocytes using 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG), a fluorescent D-glucose analog. Expression of the peroxisome proliferator-activated receptor-γ2 (PPARγ2) and adipocyte-specific fatty acid binding protein (aP2) mRNAs and the PPARγ2 protein was analyzed in adipocytes using RT-PCR and immunoblotting, respectively. Insulin-stimulated protein kinase B (Akt/PKB) phosphorylation was measured in high glucose-induced, insulin-resistant HepG2 cells. Similar to 30 μmol/l rosiglitazone, treatment with 30 μmol/l Aromadendrin significantly stimulated insulin-sensitive glucose uptake in both HepG2 cells and 3T3-L1 adipocytes. Aromadendrin treatment also enhanced adipogenesis and caused increases in the expression of PPARγ2 and aP2 mRNAs and the PPARγ2 protein in differentiated 3T3-L1 adipocytes. In high glucose-induced, insulin-resistant HepG2 cells, Aromadendrin reversed the inhibition of Akt/PKB phosphorylation in response to insulin, which could be abrogated by pretreatment with LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor. Aromadendrin treatment induced adipogenesis by increases in PPARγ2 expression, resulting in stimulation of glucose uptake and ameliorated insulin resistance.
CONCLUSIONS:
These findings suggest that Aromadendrin may represent a potential therapeutic candidate for the management of type 2 DM.
Food Sci. Biotechnol., 2011, 20(5):1283-8.
Inhibitory Activity of Aromadendrin from Prickly Pear (Opuntia ficus-indica) Root on Aldose Reductase and the Formation of Advanced Glycation End Products.[Reference: WebLink]
Prickly pear (Opuntia ficus-indica) is a longdomesticated crop plant of arid and semiarid parts of the world.
METHODS AND RESULTS:
The efficacy of extracts of prickly pear root for managing diabetes and diabetes complications was evaluated using a variety of in vitro bioassays. The ethyl acetate-soluble fraction was most effective in the prevention of diabetes and its complications via the inhibition of rat lens aldose reductase activity, the formation of advanced glycation end products, and α-glucosidase activity.
CONCLUSIONS:
MS and NMR were used to identify the bioactive compound from the ethyl acetate-soluble fraction as 3,5,7,4′-tetrahydroxyflavanone (Aromadendrin).
Aromadendrin Description
Source: The barks of Eucalyptus calophylla
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Ganolucidic acid D

Catalog No: CFN95472
CAS No: 102607-22-7
Price: $413/5mg
Dactylorhin A

Catalog No: CFN95032
CAS No: 256459-34-4
Price: $238/20mg
N-Methyltetrahydrocolumbamine

Catalog No: CFN95590
CAS No: 92758-34-4
Price: $318/10mg
Licoarylcoumarin

Catalog No: CFN95072
CAS No: 125709-31-1
Price: $413/5mg
Schisphenin E

Catalog No: CFN95223
CAS No: 1311376-52-9
Price: $318/5mg
Carasinol B

Catalog No: CFN95042
CAS No: 777857-86-0
Price: $333/5mg
Tessaric acid

Catalog No: CFN95182
CAS No: 58142-10-2
Price: $318/5mg
cis-Mulberroside A

Catalog No: CFN95006
CAS No: 166734-06-1
Price: $368/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Biomol Ther (Seoul). 2013 May 30;21(3):216-21.
Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-κB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells.[Pubmed: 24265867]
Aromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties. However, the underlying mechanism by which Aromadendrin exerts its biological activity has not been extensively demonstrated. The objective of this study is to elucidate the anti-inflammatory mechanism of aromadedrin in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells.
METHODS AND RESULTS:
Aromadendrin significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2. In accordance, Aromadendrin attenuated LPSinduced overexpression iNOS and COX-2. In addition, Aromadendrin significantly suppressed LPS-induced degradation of IκB, which sequesters NF-κB in cytoplasm, consequently inhibiting the nuclear translocation of pro-inflammatory transcription factor NF- κB. To elucidate the underlying signaling mechanism of anti-inflammatory activity of Aromadendrin, MAPK signaling pathway was examined. Aromadendrin significantly attenuated LPS-induced activation of JNK, but not ERK and p38, in a concentration-dependent manner.
CONCLUSIONS:
Taken together, the present study clearly demonstrates that Aromadendrin exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells.
trans-3-Hydroxycinnamic acid

Catalog No: CFN98181
CAS No: 14755-02-3
Price: $30/20mg
Pimaric acid

Catalog No: CFN99382
CAS No: 127-27-5
Price: $ /
Pelargonidin chloride

Catalog No: CFN92132
CAS No: 134-04-3
Price: $318/10mg
Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg
Saponarin

Catalog No: CFN90134
CAS No: 20310-89-8
Price: $288/10mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Daidzein

Catalog No: CFN98774
CAS No: 486-66-8
Price: $30/20mg
Syringetin

Catalog No: CFN70363
CAS No: 4423-37-4
Price: $ / mg
Astrasieversianin VII

Catalog No: CFN90648
CAS No: 86764-11-6
Price: $238/10mg
Juglone

Catalog No: CFN90497
CAS No: 481-39-0
Price: $40/20mg
Tags: buy Aromadendrin | Aromadendrin supplier | purchase Aromadendrin | Aromadendrin cost | Aromadendrin manufacturer | order Aromadendrin | Aromadendrin distributor