Atractylochromene | CAS:203443-33-8 | Manufacturer ChemFaces

Atractylochromene

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Description:

Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.

Targets:

Wnt/β-catenin

In vitro:

Biomol Ther (Seoul). 2015 Jan; 23(1): 26–30.

Atractylochromene Is a Repressor of Wnt/β-Catenin Signaling in Colon Cancer Cells.[Pubmed: 25593640]

Wnt/β-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated β-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the expression of its oncogenic target genes.
METHODS AND RESULTS:
In this study, we identified an inhibitor of β-catenin dependent Wnt pathway from rhizomes of Atractylodes macrocephala Koidzumi (Compositae). The active compound was purified by activity-guided purification and the structure was identified as 2,8-dimethyl-6-hydroxy-2-(4-methyl-3-pentenyl)-2H-chromene (Atractylochromene, AC). AC suppressed β-catenin/T-cell factor transcriptional activity of HEK-293 reporter cells when they were stimulated by Wnt3a or inhibitor of glycogen synthase kinase-3β. AC down-regulated the nuclear level of β-catenin through the suppression of galectin-3 mediated nuclear translocation of β-catenin in SW-480 colon cancer cells. Furthermore, AC inhibits proliferation of colon cancer cell.
CONCLUSIONS:
Taken together, AC from A. macrocephala might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.

Atractylochromene Description

Source:	The herbs of Atractylodes lancea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Atractylochromene
Price:	$318 / 10mg
CAS No.:	203443-33-8
Catalog No.:	CFN95162
Molecular Formula:	C₁₇H₂₂O₂
Molecular Weight:	258.4 g/mol
Purity:	>95%
Type of Compound:	Phenols
Physical Desc.:	Oil
Source:	The herbs of Atractylodes lancea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library Wnt/β-catenin Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.87 mL	19.3498 mL	38.6997 mL	77.3994 mL	96.7492 mL
5 mM	0.774 mL	3.87 mL	7.7399 mL	15.4799 mL	19.3498 mL
10 mM	0.387 mL	1.935 mL	3.87 mL	7.7399 mL	9.6749 mL
50 mM	0.0774 mL	0.387 mL	0.774 mL	1.548 mL	1.935 mL
100 mM	0.0387 mL	0.1935 mL	0.387 mL	0.774 mL	0.9675 mL

CFN91611	Cannabichromenic acid	185505-15-1	358.47	C₂₂H₃₀O₄
CFN95162	Atractylochromene	203443-33-8	258.4	C₁₇H₂₂O₂
CFN91935	Denudaquinol	1189105-40-5	318.41	C₁₉H₂₆O₄
CFN99828	Nervogenic acid	17622-86-5	274.4	C₁₇H₂₂O₃
CFN99652	4-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid	155051-85-7	288.3	C₁₇H₂₀O₄
CFN99633	2,2-Dimethyl-8-prenylchromene 6-carboxylic acid	151731-50-9	272.3	C₁₇H₂₀O₃
CFN91610	Cannabigerovarinic acid	64924-07-8	332.43	C₂₀H₂₈O₄
CFN98287	Cannabigerol	25654-31-3	316.5	C₂₁H₃₂O₂
CFN98039	Cannabichromene	20675-51-8	314.5	C₂₁H₃₀O₂
CFN91609	Cannabichromevarinic acid	64898-02-8	330.42	C₂₀H₂₆O₄