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Atractylochromene
Atractylochromene
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Atractylochromene
Price: $318 / 10mg
CAS No.: 203443-33-8
Catalog No.: CFN95162
Molecular Formula: C17H22O2
Molecular Weight: 258.4 g/mol
Purity: >95%
Type of Compound: Phenols
Physical Desc.: Oil
Source: The herbs of Atractylodes lancea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $144.7 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.
Targets: Wnt/β-catenin
In vitro:
Biomol Ther (Seoul). 2015 Jan; 23(1): 26–30.
Atractylochromene Is a Repressor of Wnt/β-Catenin Signaling in Colon Cancer Cells.[Pubmed: 25593640]
Wnt/β-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated β-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the expression of its oncogenic target genes.
METHODS AND RESULTS:
In this study, we identified an inhibitor of β-catenin dependent Wnt pathway from rhizomes of Atractylodes macrocephala Koidzumi (Compositae). The active compound was purified by activity-guided purification and the structure was identified as 2,8-dimethyl-6-hydroxy-2-(4-methyl-3-pentenyl)-2H-chromene (Atractylochromene, AC). AC suppressed β-catenin/T-cell factor transcriptional activity of HEK-293 reporter cells when they were stimulated by Wnt3a or inhibitor of glycogen synthase kinase-3β. AC down-regulated the nuclear level of β-catenin through the suppression of galectin-3 mediated nuclear translocation of β-catenin in SW-480 colon cancer cells. Furthermore, AC inhibits proliferation of colon cancer cell.
CONCLUSIONS:
Taken together, AC from A. macrocephala might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.
Atractylochromene Description
Source: The herbs of Atractylodes lancea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.87 mL 19.3498 mL 38.6997 mL 77.3994 mL 96.7492 mL
5 mM 0.774 mL 3.87 mL 7.7399 mL 15.4799 mL 19.3498 mL
10 mM 0.387 mL 1.935 mL 3.87 mL 7.7399 mL 9.6749 mL
50 mM 0.0774 mL 0.387 mL 0.774 mL 1.548 mL 1.935 mL
100 mM 0.0387 mL 0.1935 mL 0.387 mL 0.774 mL 0.9675 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN95162Atractylochromene203443-33-8258.4C17H22O2
CFN91935Denudaquinol1189105-40-5318.41C19H26O4
CFN99828Nervogenic acid17622-86-5274.4 C17H22O3
CFN996524-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid155051-85-7288.3 C17H20O4
CFN996332,2-Dimethyl-8-prenylchromene 6-carboxylic acid151731-50-9272.3 C17H20O3
CFN91610Cannabigerovarinic acid64924-07-8332.43C20H28O4
CFN98287Cannabigerol25654-31-3316.5 C21H32O2
CFN98039Cannabichromene20675-51-8314.5 C21H30O2
CFN91609Cannabichromevarinic acid64898-02-8330.42C20H26O4
CFN91611Cannabichromenic acid185505-15-1358.47C22H30O4
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