Biatractylolide | CAS:182426-37-5 | Manufacturer ChemFaces

Biatractylolide

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Size /Price /Stock	10 mM * 1 mL in DMSO / $174.2 / In-stock
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Description:

Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways. The molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3β.

Targets:

PI3K | Akt | GSK3β | AChR

In vitro:

Evid Based Complement Alternat Med. 2017;2017:1291458.

Biatractylolide Modulates PI3K-Akt-GSK3β-Dependent Pathways to Protect against Glutamate-Induced Cell Damage in PC12 and SH-SY5Y Cells.[Pubmed: 29075302]

Biatractylolide, isolated from the ethyl acetate extract of Atractylodes macrocephala, has shown various pharmacological activities such as antitumor and antioxidant activities.
CONCLUSIONS:
In this work, we aim to study the protective effect of Biatractylolide on glutamate-induced rat adrenal pheochromocytoma cell (PC12) and human bone marrow neuroblastoma cell line (SH-SY5Y) injury and preliminarily explore its mechanism. The results showed that glutamate was cytotoxic with an inhibitory concentration 50% (IC50) of 8.5 mM in PC12 and 10 mM in SH-SY5Y cells. In this work, the preincubation with Biatractylolide (10, 15, and 20 μM) observably improved cell viability, inhibited the apoptosis of cells induced by glutamate, and reduced the activity of LDH. AO staining revealed that apoptosis of cells was decreased. Additionally, the results of western blotting manifested that pretreatment with Biatractylolide could downregulate GSK3β protein expression and upregulate p-Akt protein expression, thereby protecting PC12 and SH-SY5Y cells from injury.
CONCLUSIONS:
All these findings indicate that Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways.

Biatractylolide Description

Source:	The roots of Atractylodes macrocephala
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Evid Based Complement Alternat Med. 2016;2016:7481323.

Primary Investigation for the Mechanism of Biatractylolide from Atractylodis Macrocephalae Rhizoma as an Acetylcholinesterase Inhibitor.[Pubmed: 27642355]

METHODS AND RESULTS:
Biatractylolide was isolated from ethyl acetate extract of dried Atractylodis Macrocephalae Rhizoma root by multistep chromatographic processing. Structure of Biatractylolide was confirmed by (1)H-NMR and (13)C-NMR. The IC50 on acetylcholinesterase (AChE) activity was 6.5458 μg/mL when the control IC50 value of huperzine A was 0.0192 μg/mL. Molecular Docking Software (MOE) was used to discover molecular sites of action between Biatractylolide and AChE protein by regular molecular docking approaches. Moreover, Biatractylolide downregulated the expression of AChE of MEF and 293T cells in a dose-dependent manner.
CONCLUSIONS:
These results demonstrated that the molecular mechanisms of inhibitory activities of Biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3β.

Structure Identification:

Chem Pharm Bull (Tokyo). 2002 Jul;50(7):964-5.

The crystal structure of biatractylolide, an 8,8' (C-C) linked dimeric 12,8-eudesmanolide from the resin of Trattinickia rhoifolia WILLD.[Pubmed: 12130855 ]

METHODS AND RESULTS:
A symmetrical dimeric sesquiterpenoid, Biatractylolide (1), was isolated from the resin of Trattinickia rhoifolia WILLD.
CONCLUSIONS:
The structure of compound 1 was elucidated by one- and two-dimensional NMR techniques and electron impact-mass spectra (EI-MS) data, and confirmed by X-ray crystallographic analysis.

Product Name	Biatractylolide
Price:	$268 / 10mg
CAS No.:	182426-37-5
Catalog No.:	CFN95205
Molecular Formula:	C₃₀H₃₈O₄
Molecular Weight:	462.6 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The roots of Atractylodes macrocephala
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library PI3K Inhibitor Library Akt Inhibitor Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1617 mL	10.8085 mL	21.6169 mL	43.2339 mL	54.0424 mL
5 mM	0.4323 mL	2.1617 mL	4.3234 mL	8.6468 mL	10.8085 mL
10 mM	0.2162 mL	1.0808 mL	2.1617 mL	4.3234 mL	5.4042 mL
50 mM	0.0432 mL	0.2162 mL	0.4323 mL	0.8647 mL	1.0808 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	0.4323 mL	0.5404 mL

CFN96438	Wedeliatrilolactone A	156993-29-2	452.49	C₂₃H₃₂O₉
CFN99348	4,8-Dihydroxyeudesm-7(11)-en-12,8-olide	1231208-53-9	266.3	C₁₅H₂₂O₄
CFN99944	Atractylenolide I	73069-13-3	230.30	C₁₅H₁₈O₂
CFN99945	Atractylenolide II	73069-14-4	232.32	C₁₅H₂₀O₂
CFN99946	Atractylenolide III	73030-71-4	248.32	C₁₅H₂₀O₃
CFN91529	Hydroxylinderstrenolide	20267-92-9	246.3	C₁₅H₁₈O₃
CFN95205	Biatractylolide	182426-37-5	462.6	C₃₀H₃₈O₄
CFN89314	8beta-Methoxyatractylenolide I	193694-24-5	262.34	C₁₆H₂₂O₃
CFN95078	Selina-4(15),7(11)-dien-8-one	54707-47-0	218.3	C₁₅H₂₂O
CFN97968	Chlorantholide A	1372558-33-2	244.3	C₁₅H₁₆O₃