Blumeatin B | CAS:79995-67-8 | Manufacturer ChemFaces

Blumeatin B

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Size /Price /Stock	10 mM * 1 mL in DMSO / $270.3 / In-stock
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Description:

Blumeatin shows XO inhibitory activity.

Targets:

Xanthine oxidase

In vitro:

Pharmaceutical Biology,2010,48(12):1405-1412.

Xanthine oxidase inhibitory activities of extracts and flavonoids of the leaves of Blumea balsamifera.[Reference: WebLink]

Blumea balsamifera DC (Compositae) leaves have been recommended for use as a folk medicine in the treatment of various diseases related to urolithiasis in southeast Asia. Phytochemical studies of this plant revealed it contains four classes of flavonoids (e.g., flavonols, flavones, flavanones, and dihydroflavonol derivatives). In view of the broad pharmacological activity of flavonoids, this study was carried out to determine the xanthine oxidase (XO) inhibitory and enzymatically produced superoxide radical scavenging activity of different organic extracts and that of the isolated flavonoids from B. balsamifera leaves.
METHODS AND RESULTS:
The inhibitory activity of XO was assayed spectrophotometrically at 295 nm. The superoxide radicals scavenging activity was assessed by NBT reduction method, spectrophotometrically at 560 nm. A dose response curve was plotted for determining IC50 values. The methanol extract (IC50 = 0.111 mg/mL) showed higher XO inhibitory activity than the chloroform (0.138 mg/mL) and pet-ether extracts (0.516 mg/mL). IC50 values of scavenging of superoxide radicals for extracts decreased in the order of: methanol (0.063 mg/mL) > chloroform (0.092 mg/mL) > pet-ether (0.321 mg/mL). The XO inhibitory activity of the isolated flavonoids and reference compounds tested decreased in the order of: allopurinol > luteolin > quercetin > tamarixetin > 5,7,3′,5′-tetrahydroxyflavanone > rhamnetin > luteolin-7-methyl ether > blumeatin > dihydroquercetin-4′-methyl ether > dihydroquercetin-7,4′-dimethyl ether > l-ascorbic acid.
CONCLUSIONS:
The results indicated that the flavone derivatives were more active than the flavonol derivatives. The flavanone derivatives were moderately active and the dihydroflavonol derivatives were the least. The higher flavonoid content of extracts contributed to their higher XO inhibitory activity.

Blumeatin B Description

Source:	The herbs of Blumea balsamifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Blumeatin B
Price:	$368 / 5mg
CAS No.:	79995-67-8
Catalog No.:	CFN97274
Molecular Formula:	C₁₇H₁₆O₇
Molecular Weight:	332.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Blumea balsamifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0093 mL	15.0466 mL	30.0933 mL	60.1866 mL	75.2332 mL
5 mM	0.6019 mL	3.0093 mL	6.0187 mL	12.0373 mL	15.0466 mL
10 mM	0.3009 mL	1.5047 mL	3.0093 mL	6.0187 mL	7.5233 mL
50 mM	0.0602 mL	0.3009 mL	0.6019 mL	1.2037 mL	1.5047 mL
100 mM	0.0301 mL	0.1505 mL	0.3009 mL	0.6019 mL	0.7523 mL

CFN92413	(-)-Dihydroquercetin	111003-33-9	304.3	C₁₅H₁₂O₇
CFN98734	Taxifolin	480-18-2	304.3	C₁₅H₁₂O₇
CFN97280	Padmatin	80453-44-7	318.3	C₁₆H₁₄O₇
CFN96563	Deodarin	33788-39-5	318.29	C₁₆H₁₄O₇
CFN97277	2',3,5,6',7-Pentahydroxyflavanone	80366-15-0	304.3	C₁₅H₁₂O₇
CFN99854	Dihydromorin	18422-83-8	304.3	C₁₅H₁₂O₇
CFN97194	Dihydrotamarixetin	70411-27-7	318.3	C₁₆H₁₄O₇
CFN97274	Blumeatin B	79995-67-8	332.3	C₁₇H₁₆O₇
CFN98671	Dihydrorobinetin	4382-33-6	304.3	C₁₅H₁₂O₇
CFN98326	Ampelopsin	27200-12-0	320.3	C₁₅H₁₂O₈