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Marginatoxin
Marginatoxin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Marginatoxin
Price: $318 / 10mg
CAS No.: 1422536-56-8
Catalog No.: CFN95174
Molecular Formula: C22H22O7
Molecular Weight: 398.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The roots of Bupleurum marginatum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $175.7 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.
Targets: Caspase | Fas/FasL
In vitro:
Phytochemistry Letters, 2012, 5(2):387-392.
A novel cytotoxic aryltetraline lactone from Bupleurum marginatum (Apiaceae)[Reference: WebLink]

METHODS AND RESULTS:
A detailed phytochemical study of the aerial parts of Bupleurum marginatum Wall. ex DC revealed a novel aryltetraline lactone lignan identified as 9-(benzo[d][1,3]dioxol-5-yl)-6,7,8-trimethoxy-3a,4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one (Marginatoxin) along with nine known compounds and characterization of five other compounds either by GLC/MS or LC/MS techniques. Chemical structures of the isolated compounds were unambiguously elucidated by both 1D, 2D NMR and mass spectrometry techniques.The in vitro cytotoxic activity of both methanol and dichloromethane extracts as well as the isolated compounds was assessed in two human cancer cell lines HepG2 and HeLa using the MTT assay.
CONCLUSIONS:
The new aryltetraline lactone lignan exhibited a potent cytotoxic activity with IC50 values of 12.14 and 16.90 μM after 24 h treatment for HepG2 and HeLa cells, respectively.
Marginatoxin Description
Source: The roots of Bupleurum marginatum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.51 mL 12.5502 mL 25.1004 mL 50.2008 mL 62.751 mL
5 mM 0.502 mL 2.51 mL 5.0201 mL 10.0402 mL 12.5502 mL
10 mM 0.251 mL 1.255 mL 2.51 mL 5.0201 mL 6.2751 mL
50 mM 0.0502 mL 0.251 mL 0.502 mL 1.004 mL 1.255 mL
100 mM 0.0251 mL 0.1255 mL 0.251 mL 0.502 mL 0.6275 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Biomedical Research,2017,28(3).
Marginatoxin induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.[Reference: WebLink]
Marginatoxin, an aryltetraline lactone lignan isolated from Bupleurum marginatum Wall. ex DC (Apiaceae), showed cytotoxic activity against human hepatocellular carcinoma. However, the cytotoxic mechanisms of Marginatoxin against cancer cells remained unclear.
METHODS AND RESULTS:
This study was designed to investigate the detailed mechanism of its cytotoxic effect on human hepatoma BEL-7402 cells by CCK-8, flow cytometry, western blot and xenograft assays. Marginatoxin caused a dose-dependent growth inhibition of BEL-7402 cells with an IC50 of 15.20 μg/ml. Marginatoxin induced BEL-7402 cells apoptosis identified by annexing V/propidium iodide staining kits with the aid of flow cytometry. Marginatoxin-induced apoptosis was characterized by increasing Fas, FasL and Fas associated protein with death domain expression, and cleavage of caspase-8, caspase-10, caspase-3. Furthermore, the results of xenograft assay suggested that Marginatoxin inhibited the BEL-7402 cells-induced tumor growth without effect on body weight of nude mice in vivo by regulating the expression levels of above apoptotic proteins. These results demonstrated that Marginatoxin could induce apoptosis of human hepatoma BEL-7402 cells in vitro and in vivo through activation of Fas/FasL-mediated apoptotic pathway.
CONCLUSIONS:
All these findings demonstrated that Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma. Moreover, there is a need to further investigate Marginatoxin in this regard.
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