Marginatoxin | CAS:1422536-56-8 | Manufacturer ChemFaces

Marginatoxin

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $175.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

Universit?t Basel (Switzerland)
University of Mysore (India)
University of Sao Paulo (Brazil)
University of Oslo (Norway)

Sri Sai Aditya Institute of Pha... (India)
Pennsylvania State University (USA)
Martin Luther University of Hal... (Germany)
Wageningen University (Netherlands)

University of Malaya (Malaysia)
Korea Food Research Institute(K... (Korea)
Institute of Chinese Materia Me... (China)
More...

Package

Featured Products

More...

Intermedine N-oxide

Catalog No: CFN00459
CAS No: 95462-14-9
Price: $ / mg

Naringenin chalcone

Catalog No: CFN90606
CAS No: 73692-50-9
Price: $168/20mg

Corilagin

Catalog No: CFN90176
CAS No: 23094-69-1
Price: $50/20mg

Acteoside

Catalog No: CFN97048
CAS No: 61276-17-3
Price: $60/20mg

Xanthohumol

Catalog No: CFN98958
CAS No: 569-83-5; 6754-58-1
Price: $60/20mg

Salvianolic acid A

Catalog No: CFN99161
CAS No: 96574-01-5
Price: $128/20mg

Secoisolariciresinol

Catalog No: CFN98363
CAS No: 29388-59-8
Price: $288/10mg

D-(+)-Glucose

Catalog No: CFN99769
CAS No: 50-99-7
Price: $30/20mg

Angelicide

Catalog No: CFN93012
CAS No: 92935-94-9
Price: $ / mg

Isosilybin B

Catalog No: CFN91071
CAS No: 142796-22-3
Price: $368/10mg

Description:

Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.

Targets:

Caspase | Fas/FasL

In vitro:

Phytochemistry Letters, 2012, 5(2):387-392.

A novel cytotoxic aryltetraline lactone from Bupleurum marginatum (Apiaceae)[Reference: WebLink]

METHODS AND RESULTS:
A detailed phytochemical study of the aerial parts of Bupleurum marginatum Wall. ex DC revealed a novel aryltetraline lactone lignan identified as 9-(benzo[d][1,3]dioxol-5-yl)-6,7,8-trimethoxy-3a,4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one (Marginatoxin) along with nine known compounds and characterization of five other compounds either by GLC/MS or LC/MS techniques. Chemical structures of the isolated compounds were unambiguously elucidated by both 1D, 2D NMR and mass spectrometry techniques.The in vitro cytotoxic activity of both methanol and dichloromethane extracts as well as the isolated compounds was assessed in two human cancer cell lines HepG2 and HeLa using the MTT assay.
CONCLUSIONS:
The new aryltetraline lactone lignan exhibited a potent cytotoxic activity with IC50 values of 12.14 and 16.90 μM after 24 h treatment for HepG2 and HeLa cells, respectively.

Marginatoxin Description

Source:	The roots of Bupleurum marginatum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biomedical Research,2017,28(3).

Marginatoxin induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.[Reference: WebLink]

Marginatoxin, an aryltetraline lactone lignan isolated from Bupleurum marginatum Wall. ex DC (Apiaceae), showed cytotoxic activity against human hepatocellular carcinoma. However, the cytotoxic mechanisms of Marginatoxin against cancer cells remained unclear.
METHODS AND RESULTS:
This study was designed to investigate the detailed mechanism of its cytotoxic effect on human hepatoma BEL-7402 cells by CCK-8, flow cytometry, western blot and xenograft assays. Marginatoxin caused a dose-dependent growth inhibition of BEL-7402 cells with an IC50 of 15.20 μg/ml. Marginatoxin induced BEL-7402 cells apoptosis identified by annexing V/propidium iodide staining kits with the aid of flow cytometry. Marginatoxin-induced apoptosis was characterized by increasing Fas, FasL and Fas associated protein with death domain expression, and cleavage of caspase-8, caspase-10, caspase-3. Furthermore, the results of xenograft assay suggested that Marginatoxin inhibited the BEL-7402 cells-induced tumor growth without effect on body weight of nude mice in vivo by regulating the expression levels of above apoptotic proteins. These results demonstrated that Marginatoxin could induce apoptosis of human hepatoma BEL-7402 cells in vitro and in vivo through activation of Fas/FasL-mediated apoptotic pathway.
CONCLUSIONS:
All these findings demonstrated that Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma. Moreover, there is a need to further investigate Marginatoxin in this regard.

Product Name	Marginatoxin
Price:	$318 / 10mg
CAS No.:	1422536-56-8
Catalog No.:	CFN95174
Molecular Formula:	C₂₂H₂₂O₇
Molecular Weight:	398.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The roots of Bupleurum marginatum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.51 mL	12.5502 mL	25.1004 mL	50.2008 mL	62.751 mL
5 mM	0.502 mL	2.51 mL	5.0201 mL	10.0402 mL	12.5502 mL
10 mM	0.251 mL	1.255 mL	2.51 mL	5.0201 mL	6.2751 mL
50 mM	0.0502 mL	0.251 mL	0.502 mL	1.004 mL	1.255 mL
100 mM	0.0251 mL	0.1255 mL	0.251 mL	0.502 mL	0.6275 mL

CFN70412	alpha-Peltatin	568-53-6	400.4	C₂₁H₂₀O₈
CFN92699	(-)-beta-Peltatin	518-29-6	414.4	C₂₂H₂₂O₈
CFN92700	(-)-beta-Peltatin-5-O-beta-D-glucopyranoside	11024-59-2	576.6	C₂₈H₃₂O₁₃
CFN99888	Deoxypodophyllotoxin	19186-35-7	398.4	C₂₂H₂₂O₇
CFN90483	4'-Demethylpodophyllotoxin	40505-27-9	400.37	C₂₁H₂₀O₈
CFN89061	Etoposide	33419-42-0	588.56	C₂₉H₃₂O₁₃
CFN91909	Podophyllotoxinone	477-49-6	412.39	C₂₂H₂₀O₈
CFN90443	Picropodophyllotoxin	17434-18-3	414.4	C₂₂H₂₂O₈
CFN99168	Podophyllotoxin	518-28-5	414.41	C₂₂H₂₂O₈
CFN91618	Epipodophyllotoxin	4375-07-9	414.41	C₂₂H₂₂O₈