Canophyllal | CAS:14440-40-5 | Manufacturer ChemFaces

Canophyllal

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Description:

Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.

Targets:

Antifection

In vitro:

Chem Pharm Bull (Tokyo). 2008 Mar;56(3):374-7.

Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides.[Pubmed: 18310952]

METHODS AND RESULTS:
From the ethyl acetate extract of the stem bark of Endodesmia calophylloides (Guttiferae), a novel friedelane triterpenoid named endodesmiadiol (1), as well as the known compounds friedelin (2), canophyllol (3), Canophyllal (4), cerin (5), morelloflavone (6), volkensiflavone (7), 8-deoxygartanin (8), 3 beta-acetoxyoleanolic acid (9) and 1,8-dihydroxy-3-isoprenyloxy-6-methylxanthone (10) have been isolated. The structures of these compounds were established by spectroscopic analysis, and the relative configuration of endodesmiadiol (1) was confirmed by X-ray diffraction. The antiplasmodial activity of the isolated compounds was evaluated against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.
CONCLUSIONS:
All the compounds were found to be active with IC50 values ranging from 7.2 to 23.6 microM. The IC50 of endodesmiadiol was found to be 11.8 microM.

Canophyllal Description

Source:	The stem bark of Endodesmia calophylloides.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Canophyllal
Price:
CAS No.:	14440-40-5
Catalog No.:	CFN89150
Molecular Formula:	C₃₀H₄₈O₂
Molecular Weight:	440.71 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The stem bark of Endodesmia calophylloides.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antimalaric Compound Library Triterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2691 mL	11.3453 mL	22.6907 mL	45.3813 mL	56.7266 mL
5 mM	0.4538 mL	2.2691 mL	4.5381 mL	9.0763 mL	11.3453 mL
10 mM	0.2269 mL	1.1345 mL	2.2691 mL	4.5381 mL	5.6727 mL
50 mM	0.0454 mL	0.2269 mL	0.4538 mL	0.9076 mL	1.1345 mL
100 mM	0.0227 mL	0.1135 mL	0.2269 mL	0.4538 mL	0.5673 mL

CFN96834	Polpunonic acid	33600-93-0	456.71	C₃₀H₄₈O₃
CFN96837	Salaspermic acid	71247-78-4	472.71	C₃₀H₄₈O₄
CFN89150	Canophyllal	14440-40-5	440.71	C₃₀H₄₈O₂
CFN98260	Bryonolic acid	24480-45-3	456.7	C₃₀H₄₈O₃
CFN99152	Glycyrrhetinic acid	471-53-4	470.64	C₃₀H₄₆O₄
CFN97747	28-Hydroxy-3-oxoolean-12-en-29-oic acid	381691-22-1	470.69	C₃₀H₄₆O₄
CFN99487	22-Hydroxy-3-oxoolean-12-en-29-oic acid	144629-84-5	470.7	C₃₀H₄₆O₄
CFN97288	3,22-Dihydroxyolean-12-en-29-oic acid	808769-54-2	472.7	C₃₀H₄₈O₄
CFN98018	Triptocallic acid D	201534-09-0	472.7	C₃₀H₄₈O₄
CFN96474	Triptotriterpenic acid A	84108-17-8	472.70	C₃₀H₄₈O₄