1-Acetyl-beta-carboline | CAS:50892-83-6

1-Acetyl-beta-carboline

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Description:

Combination of 1-acetyl-beta-carboline with ampicillin exhibits synergistic antibacterial activity against MRSA.

Targets:

Antifection

In vitro:

J Microbiol Biotechnol. 2010 Mar;20(3):501-5.

The synergistic antibacterial activity of 1-acetyl-beta-carboline and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA).[Pubmed: 20372018]

METHODS AND RESULTS:
1-Acetyl-beta-carboline was isolated as an anti-MRSA agent from the fermentation broth of a marine actinomycete isolated from marine sediment. The producing strain was identified to be Streptomyces sp. by phylogenetic analysis of the 16S rRNA gene sequence. The anti-MRSA agent was isolated by bioactivity-guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and purification with a reversed-phase HPLC. Its structure was elucidated by extensive 2D NMR and mass spectral analyses.
CONCLUSIONS:
Combination of 1-Acetyl-beta-carboline with ampicillin exhibited synergistic antibacterial activity against MRSA.

1-Acetyl-beta-carboline Description

Source:	The barks of Picrasma quassioides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	1-Acetyl-beta-carboline
Price:
CAS No.:	50892-83-6
Catalog No.:	CFN92122
Molecular Formula:	C₁₃H₁₀N₂O
Molecular Weight:	210.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The barks of Picrasma quassioides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.7574 mL	23.7869 mL	47.5737 mL	95.1475 mL	118.9343 mL
5 mM	0.9515 mL	4.7574 mL	9.5147 mL	19.0295 mL	23.7869 mL
10 mM	0.4757 mL	2.3787 mL	4.7574 mL	9.5147 mL	11.8934 mL
50 mM	0.0951 mL	0.4757 mL	0.9515 mL	1.9029 mL	2.3787 mL
100 mM	0.0476 mL	0.2379 mL	0.4757 mL	0.9515 mL	1.1893 mL

CFN99020	Picrasidine J	100234-62-6	242.3	C₁₄H₁₄N₂O₂
CFN97116	Dehydrocrenatidine	65236-62-6	254.3	C₁₅H₁₄N₂O₂
CFN92122	1-Acetyl-beta-carboline	50892-83-6	210.2	C₁₃H₁₀N₂O
CFN98456	1-Methoxycarbonyl-beta-carboline	3464-66-2	226.2	C₁₃H₁₀N₂O₂
CFN91567	1-Formyl-beta-carboline	20127-63-3	196.2	C₁₂H₈N₂O
CFN95291	Perlolyrine	29700-20-7	264.3	C₁₆H₁₂N₂O₂
CFN95023	1-Methoxycarbonyl-beta-carboline-N-oxide	74690-74-7	242.2	C₁₃H₁₀N₂O₃
CFN92123	1-Ethoxycarbonyl-beta-carboline	72755-19-2	240.3	C₁₄H₁₂N₂O₂
CFN92929	4-Hydroxy-1-methoxycarbonyl-beta-carboline	74690-72-5	242.23	C₁₃H₁₀N₂O₃
CFN97037	4-Methoxy-1-methoxycarbonyl-beta-carboline	60807-25-2	256.3	C₁₄H₁₂N₂O₃