Science | Nature | Cell | View More
Natural Products
Cephalotaxine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cephalotaxine
Price: $40 / 20mg
CAS No.: 24316-19-6
Catalog No.: CFN90919
Molecular Formula: C18H21NO4
Molecular Weight: 315.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The barks of Cephalotaxus fortunei Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $10.8 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • MTT Agrifood Research Finland (Finland)
  • Cancer Research Initatives Foun... (Malaysia)
  • Mahidol University (Thailand)
  • Universidad de Buenos Aires (Argentina)
  • Colorado State University (USA)
  • University of the Basque Country (Spain)
  • Monash University Malaysia (Malaysia)
  • Vin?a Institute of Nuclear Scie... (Serbia)
  • Ain Shams University (Egypt)
  • Molecular Biology Institute of ... (Spain)
  • University of Mysore (India)
  • More...
Package
Featured Products
Carnosol

Catalog No: CFN99956
CAS No: 5957-80-2
Price: $80/20mg
Ginsenoside Rk3

Catalog No: CFN92593
CAS No: 364779-15-7
Price: $180/10mg
Tetrahydrocurcumin

Catalog No: CFN90583
CAS No: 36062-04-1
Price: $30/20mg
Dihydroevocarpine

Catalog No: CFN92786
CAS No: 15266-35-0
Price: $268/10mg
Benzoic acid

Catalog No: CFN97121
CAS No: 65-85-0
Price: $25/20mg
Dulcoside A

Catalog No: CFN92266
CAS No: 64432-06-0
Price: $ / mg
3-Hydroxy-4-methoxycinnamic acid

Catalog No: CFN99135
CAS No: 537-73-5
Price: $30/20mg
Dehydrocostus lactone

Catalog No: CFN98720
CAS No: 477-43-0
Price: $40/20mg
Yatein

Catalog No: CFN98635
CAS No: 40456-50-6
Price: $ /
3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cephalotaxine is an antiviral as well as antitumor agent. It is useless for the treatment of infection by flaviviruses, but potentially useful in combined therapy against hepatitis B.
Targets: HBV
In vitro:
Planta Med. 2007 Jun;73(6):552-8.
Effect of cantharidin, cephalotaxine and homoharringtonine on [Pubmed: 17458779 ]
The effect as antiviral agents versus viral hepatitis B and C of three compounds purified from natural products commonly used as remedies in traditional Chinese medicine, cantharidin, Cephalotaxine and homoharingtonine, was investigated.
METHODS AND RESULTS:
To assess the activity of these compounds against flavivirus, we used bovine viral diarrhoea virus (BVDV) as a surrogate for hepatitis C virus (HCV). Anti-BVDV activity was determined by reduction in BVDV-RNA production and protection of infected embryonic bovine trachea (EBTr) cells against the cytopathic effect of BVDV. The effect versus hepatitis B virus (HBV) was investigated by measuring HBsAg and HBV-DNA release from hepatoblastoma HepG2 2.2.15 cells infected with HBV. As positive control we used the standard anti-HBV and anti-HCV drugs, lamivudine and ribavirin, respectively. Up to 100 microM lamivudine and ribavirin did not induce cell toxicity, whereas they induced dose-dependent anti-HBV and anti-BVDV effects, respectively. In the same range, cantharidin, Cephalotaxine and homoharringtonine induced toxicity in EBTr cells and had no protective effect against BVDV.
CONCLUSIONS:
In contrast, they were able to inhibit HBV production at concentrations 10- to 100-fold lower than those inducing cell toxicity, which suggests that they are useless for the treatment of infection by flaviviruses, but potentially useful in combined therapy against hepatitis B.
Cephalotaxine Description
Source: The barks of Cephalotaxus fortunei Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Rhamnocitrin 3-apiosyl-(1->2)-gluc...

Catalog No: CFN95145
CAS No: 148031-68-9
Price: $318/10mg
Lyciumamide B

Catalog No: CFN95286
CAS No: 1647111-41-8
Price: $318/5mg
Ganoderic acid beta

Catalog No: CFN95537
CAS No: 217476-76-1
Price: $413/5mg
Sophoraflavone A

Catalog No: CFN95510
CAS No: 105594-08-9
Price: $318/10mg
(Z)-Aldosecologanin (Centauroside)

Catalog No: CFN95079
CAS No: 82474-97-3
Price: $388/5mg
N-Methyltetrahydrocolumbamine

Catalog No: CFN95590
CAS No: 92758-34-4
Price: $318/10mg
Ganoderiol D

Catalog No: CFN95568
CAS No: 114567-45-2
Price: $413/5mg
10-O-trans-p-Feruloylscandoside

Catalog No: CFN95392
CAS No: 1428268-72-7
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1706 mL 15.8529 mL 31.7058 mL 63.4115 mL 79.2644 mL
5 mM 0.6341 mL 3.1706 mL 6.3412 mL 12.6823 mL 15.8529 mL
10 mM 0.3171 mL 1.5853 mL 3.1706 mL 6.3412 mL 7.9264 mL
50 mM 0.0634 mL 0.3171 mL 0.6341 mL 1.2682 mL 1.5853 mL
100 mM 0.0317 mL 0.1585 mL 0.3171 mL 0.6341 mL 0.7926 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Nat Prod Commun. 2016 Jan;11(1):57-62.
Molecular Docking and Binding Mode Analysis of Plant Alkaloids as in vitro and in silico Inhibitors of Trypanothione Reductase from Trypanosoma cruzi.[Pubmed: 26996020]
Trypanothione reductase (TryR) is a key enzyme in the metabolism of Trypanosoma cruzi, the parasite responsible for Chagas disease. The available repertoire of TryR inhibitors relies heavily on synthetic substrates of limited structural diversity, and less on plant-derived natural products.
METHODS AND RESULTS:
In this study, a molecular docking procedure using a Lamarckian Genetic Algorithm was implemented to examine the protein-ligand binding interactions of strong in vitro inhibitors for which no X-ray data is available. In addition, a small, skeletally diverse, set of natural alkaloids was assessed computationally against T. cruzi TryR in search of new scaffolds for lead development. The preferential binding mode (low number of clusters, high cluster population), together with the deduced binding interactions were used to discriminate among the virtual inhibitors.
CONCLUSIONS:
This study confirms the prior in vitro data and proposes quebrachamine, Cephalotaxine, cryptolepine, (22S,25S)-tomatidine, (22R,25S)-solanidine, and (22R,25R)-solasodine as new alkaloid scaffold leads in the search for more potent and selective TryR inhibitors.
Carnosol

Catalog No: CFN99956
CAS No: 5957-80-2
Price: $80/20mg
Ginsenoside Rk3

Catalog No: CFN92593
CAS No: 364779-15-7
Price: $180/10mg
Tetrahydrocurcumin

Catalog No: CFN90583
CAS No: 36062-04-1
Price: $30/20mg
Dihydroevocarpine

Catalog No: CFN92786
CAS No: 15266-35-0
Price: $268/10mg
Benzoic acid

Catalog No: CFN97121
CAS No: 65-85-0
Price: $25/20mg
Dulcoside A

Catalog No: CFN92266
CAS No: 64432-06-0
Price: $ / mg
3-Hydroxy-4-methoxycinnamic acid

Catalog No: CFN99135
CAS No: 537-73-5
Price: $30/20mg
Dehydrocostus lactone

Catalog No: CFN98720
CAS No: 477-43-0
Price: $40/20mg
Yatein

Catalog No: CFN98635
CAS No: 40456-50-6
Price: $ /
3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg
Tags: buy Cephalotaxine | Cephalotaxine supplier | purchase Cephalotaxine | Cephalotaxine cost | Cephalotaxine manufacturer | order Cephalotaxine | Cephalotaxine distributor