Ginsenoside Rk3 | CAS:364779-15-7 | Manufacturer ChemFaces

Ginsenoside Rk3

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Size /Price /Stock	10 mM * 1 mL in DMSO / $109.0 / In-stock
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Description:

Ginsenoside Rk3 is often used as a major ingredient of the compound preparation for ischemic heart diseases, it could have a role in treating inflammatory diseases. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells.

Targets:

Bcl-2/Bax | Caspase | Akt | Nrf2 | HO-1 | MAPK | NF-κB

In vitro:

Evid Based Complement Alternat Med. 2013;2013:690190.

Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway.[Pubmed: 23935671 ]

Cardiac hypertrophy is a thickening of the heart muscle that is associated with cardiovascular diseases such as hypertension and myocardial infarction. It occurs initially as an adaptive process against increased workloads and often leads to sudden arrhythmic deaths. Studies suggest that the lethal arrhythmia is attributed to hypertrophy-induced destabilization of cardiac electrical activity, especially the prolongation of the action potential. The reduced activity of Ito is demonstrated to be responsible for the ionic mechanism of prolonged action potential duration and arrhythmogeneity. Isosteviol (STV), a derivative of stevioside, plays a protective role in a variety of stress-induced cardiac diseases.
METHODS AND RESULTS:
Here we report effects of STV on rat ISO-induced hypertrophic cardiomyocytes. STV alleviated ISO-induced hypertrophy of cardiomyocytes by decreasing cell area of hypertrophied cardiomyocytes. STV application prevented the prolongation of action potential which was prominent in hypertrophied cells.
CONCLUSIONS:
The decrease and increase of current densities for Ito and ICaL observed in hypertrophied myocytes were both prevented by STV application. In addition, the results of qRT-PCR suggested that the changes of electrophysiological activity of Ito and ICaL are correlated to the alterations of the mRNA transcription level.

In vivo:

Food Funct . 2017 Oct 18;8(10):3723-3736.

Anticancer effects of ginsenoside Rk3 on non-small cell lung cancer cells: in vitro and in vivo[Pubmed: 28949353]

Abstract Ginsenoside Rk3 (Rk3) is present in the roots of processed Panax notoginseng herbs and it exerts anti-platelet aggregation, pro-immunogenic and cardioprotective effects. However, little is known regarding the anticancer activities of this compound, especially in lung cancer. This study was designed to investigate the anticancer effects of Rk3 on non-small cell lung cancer (NSCLC) cells and in an H460 xenograft tumor model. Our results showed that Rk3 reduced cell viability, inhibited both cell proliferation and colony formation, and induced G1 phase cell cycle arrest by downregulating the expression of cyclin D1 and CDK4 and upregulating the expression of P21. Rk3 also induced apoptosis in a concentration-dependent manner in H460 and A549 cells by Annexin V/PI staining, TUNEL assay and JC-1 staining, resulting in a change in the nuclear morphology. Moreover, Rk3 induced the activation of caspase-8, -9, and -3, promoted changes in mitochondrial membrane potential, decreased the expression of Bcl-2, increased the expression of Bax, and caused the release of cytochrome c, which indicated that the apoptosis-inducing effects of Rk3 were triggered via death receptor-mediated mitochondria-dependent pathways. Furthermore, Rk3 significantly inhibited the growth of H460 xenograft tumors without an obvious effect on the body weight of the treated mice. Histological analysis indicated that Rk3 inhibited tumor growth by altering the proliferation and morphology of tumor cells. In addition, we confirmed that Rk3 inhibited angiogenesis via CD34 staining and chick embryo chorioallantoic membrane (CAM) assay in vivo. Taken together, our findings revealed not only the anticancer effect of Rk3 on NSCLC cells but also a new promising therapeutic agent for human NSCLC.

Ginsenoside Rk3 Description

Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Biol Pharm Bull. 2011;34(6):898-900.

Anti-complementary ginsenosides isolated from processed ginseng.[Pubmed: 21628891]

METHODS AND RESULTS:
As part of an ongoing search for immunomodulatory components aimed at the anti-complementary effect, ginsenosides isolated from processed ginseng were found to have inhibitory activity on complement activation through classical pathways. Activity-guided fractionation was used to isolate four ginsenosides, namely ginsenoside Rg₆, F₄, Rk₃, and Rh₄. Ginsenoside Rk₃ and Rh₄ had a 3 fold higher inhibition activity than rosmarinic acid which was used as a positive control while ginsenoside Rg₆ and F₄ showed only mild effects similar to that of the positive control.
CONCLUSIONS:
The results suggest that the activity of the corresponding ginsenosides may be increased by the glycosyl moiety at the C₆ position rather than the double bond conformation at C₂₀, and ginsenoside Rk₃ and Rh₄ could have a role in treating inflammatory diseases.

Product Name	Ginsenoside Rk3
Price:	$180 / 10mg
CAS No.:	364779-15-7
Catalog No.:	CFN92593
Molecular Formula:	C₃₆H₆₀O₈
Molecular Weight:	620.9 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Cardioprotective Compound Library Nephroprotective Compound Library Triterpenoids Compound Library Nrf2 Inhibitor Library MAPK Inhibitor Library HO-1 Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6106 mL	8.0528 mL	16.1057 mL	32.2113 mL	40.2641 mL
5 mM	0.3221 mL	1.6106 mL	3.2211 mL	6.4423 mL	8.0528 mL
10 mM	0.1611 mL	0.8053 mL	1.6106 mL	3.2211 mL	4.0264 mL
50 mM	0.0322 mL	0.1611 mL	0.3221 mL	0.6442 mL	0.8053 mL
100 mM	0.0161 mL	0.0805 mL	0.1611 mL	0.3221 mL	0.4026 mL

CFN92818	Ginsenoside Rk2	364779-14-6	604.9	C₃₆H₆₀O₇
CFN92644	Ginsenoside Rk1	494753-69-4	767.0	C₄₂H₇₀O₁₂
CFN99972	Ginsenoside Rh3	105558-26-7	604.86	C₃₆H₆₀O₇
CFN92643	Ginsenoside Rg5	186763-78-0	767.0	C₄₂H₇₀O₁₂
CFN91838	Damulin A	1202868-74-3	783.0	C₄₂H₇₀O₁₃
CFN91837	Damulin B	1202868-75-4	783.0	C₄₂H₇₀O₁₃
CFN92593	Ginsenoside Rk3	364779-15-7	620.9	C₃₆H₆₀O₈
CFN90565	Ginsenoside Rg6	147419-93-0	766.5	C₄₂H₇₀O₁₂
CFN92594	Ginsenoside Rh4	174721-08-5	620.9	C₃₆H₆₀O₈
CFN90572	Ginsenoside Rg4	126223-28-7	767.0	C₄₂H₇₀O₁₂