Science | Nature | Cell | View More
Natural Products
Cimicifugic acid B
Cimicifugic acid B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cimicifugic acid B
Price:
CAS No.: 205114-66-5
Catalog No.: CFN70303
Molecular Formula: C21H20O11
Molecular Weight: 448.4 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Cimicifuga simplex
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Chungnam National University (Korea)
  • Chulalongkorn University (Thailand)
  • Complutense University of Madrid (Spain)
  • Massachusetts General Hospital (USA)
  • Macau University of Science and... (China)
  • Sri Sai Aditya Institute of Pha... (India)
  • Universite Libre de Bruxelles (Belgium)
  • Centralised Purchases Unit (CPU... (India)
  • Universidad de Ciencias y Artes... (Mexico)
  • Charles University in Prague (Czech Republic)
  • University of Minnesota (USA)
  • More...
Package
Featured Products
Ginsenoside F1

Catalog No: CFN99754
CAS No: 53963-43-2
Price: $90/20mg
Eriodictyol

Catalog No: CFN99719
CAS No: 552-58-9
Price: $128/20mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Scutellarein

Catalog No: CFN98557
CAS No: 529-53-3
Price: $60/20mg
Loganic acid

Catalog No: CFN98212
CAS No: 22255-40-9
Price: $50/20mg
Chrysosplenetin

Catalog No: CFN97026
CAS No: 603-56-5
Price: $138/20mg
Betaine

Catalog No: CFN99546
CAS No: 107-43-7
Price: $30/20mg
Dehydrocostus lactone

Catalog No: CFN98720
CAS No: 477-43-0
Price: $40/20mg
Albiflorin

Catalog No: CFN99774
CAS No: 39011-90-0
Price: $50/20mg
Physalin L

Catalog No: CFN90166
CAS No: 113146-74-0
Price: $288/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cimicifugic acid B shows inhibitory collagenolytic activity.
In vitro:
Biological & pharmaceutical bulletin, 2002, 24(10):1198-201.
Effects of Fukinolic Acid and Cimicifugic Acids from Cimicifuga Species on Collagenolytic Activity.[Reference: WebLink]

METHODS AND RESULTS:
The inhibitory collagenolytic activity (47-64% inhibition in 0.22-0.24 microM) of fukinolic acid and cimicifugic acid A, Cimicifugic acid B, and cimicifugic acid C, which are esters of fukiic acid (3',4'-dihydroxybenzyl tartaric acid) was more potent than that (20-37% inhibition in 0.23-0.24 microM) of cimicifugic acids D, E, F, which are esters of pscidic acid (4'-hydroxybenzyl tartaric acid). Since fukiic acid showed weaker inhibition, and caffeic acid, ferulic acid, isoferulic acid, and p-coumaric acid showed far weaker activities, the entire structures of fukinolic acid and cimicifugic acid A, Cimicifugic acid B, and cimicifugic acid C proved to be responsible for the inhibitory activities. Trypsin and pronase E hydrolyzed collagen nonselectively alone or in addition to collagenase. These collagenolytic activities were also inhibited by fukinolic acid. These results show that fukinolic acid may inhibit either the collagenolytic activities specific to collagenase or nonspecific to other emzymes.
CONCLUSIONS:
The present studies suggest the potential effect of fukinolic acid and cimicifugic acids of Cimicifuga rhizomes in preventing collagen degradation by collagenases or collagenolytic enzymes under pathological conditions, wound healing, or inflammation.
Cimicifugic acid B Description
Source: The herbs of Cimicifuga simplex
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isorhamnetin-3-O-rutinoside-7-O-gl...

Catalog No: CFN95494
CAS No: 55481-91-9
Price: $318/5mg
15-Methoxy-16-oxo-15,16H-strictic ...

Catalog No: CFN95261
CAS No: 1356388-38-9
Price: $368/5mg
6''-O-acetylsaikosaponin A

Catalog No: CFN95086
CAS No: 64340-46-1
Price: $268/10mg
Ganolucidic acid B

Catalog No: CFN95513
CAS No: 98683-75-1
Price: $413/5mg
Senkyunolide N

Catalog No: CFN95449
CAS No: 140694-58-2
Price: $318/10mg
9,11-Dehydro-beta-boswellic acid

Catalog No: CFN95335
CAS No: 471-65-8
Price: $318/5mg
Dihydrophaseic acid 4'-O-beta-D-gl...

Catalog No: CFN95393
CAS No: 78914-56-4
Price: $318/5mg
8-epi-Confertin

Catalog No: CFN95509
CAS No: 110115-60-1
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2302 mL 11.1508 mL 22.3015 mL 44.603 mL 55.7538 mL
5 mM 0.446 mL 2.2302 mL 4.4603 mL 8.9206 mL 11.1508 mL
10 mM 0.223 mL 1.1151 mL 2.2302 mL 4.4603 mL 5.5754 mL
50 mM 0.0446 mL 0.223 mL 0.446 mL 0.8921 mL 1.1151 mL
100 mM 0.0223 mL 0.1115 mL 0.223 mL 0.446 mL 0.5575 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemical and Pharmaceutical Bulletin, 1988,46(2):362-365.
Three New Fukiic Acid Esters, Cimicifugic Acids A, B and C, from Cimicifuga Simplex WORMSK.[Reference: WebLink]

METHODS AND RESULTS:
Three new fukiic acid esters, cimicifugic acid A (1), Cimicifugic acid B (2), and cimicifugic acid C (3), were isolated along with fukinolic acid (4), fukiic acid (5), caffeic acid (6), ferulic acid (7), isoferulic acid (8), 3, 4-dimethoxycinnamic acid (9) and p-coumaric acid (10) from Cimicifuga simplex.
CONCLUSIONS:
Their structures were identified as 2-feruloyl, 2-isoferuloyl, and 2-p-coumaroyl fukiic acid (1-3) on the basis of spectroscopic and chemical data.
Ginsenoside F1

Catalog No: CFN99754
CAS No: 53963-43-2
Price: $90/20mg
Eriodictyol

Catalog No: CFN99719
CAS No: 552-58-9
Price: $128/20mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Scutellarein

Catalog No: CFN98557
CAS No: 529-53-3
Price: $60/20mg
Loganic acid

Catalog No: CFN98212
CAS No: 22255-40-9
Price: $50/20mg
Chrysosplenetin

Catalog No: CFN97026
CAS No: 603-56-5
Price: $138/20mg
Betaine

Catalog No: CFN99546
CAS No: 107-43-7
Price: $30/20mg
Dehydrocostus lactone

Catalog No: CFN98720
CAS No: 477-43-0
Price: $40/20mg
Albiflorin

Catalog No: CFN99774
CAS No: 39011-90-0
Price: $50/20mg
Physalin L

Catalog No: CFN90166
CAS No: 113146-74-0
Price: $288/5mg
Tags: buy Cimicifugic acid B | Cimicifugic acid B supplier | purchase Cimicifugic acid B | Cimicifugic acid B cost | Cimicifugic acid B manufacturer | order Cimicifugic acid B | Cimicifugic acid B distributor