Cinchonine | CAS:118-10-5 | Manufacturer ChemFaces

Cinchonine

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $8.9 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

University of the Basque Country (Spain)
Mahidol University (Thailand)
Instituto Politécnico de Bragan?a (Portugal)
Funda??o Universitária de Dese... (Brazil)

Ain Shams University (Egypt)
Max-Planck-Insitut (Germany)
VIB Department of Plant Systems... (Belgium)
Universiti Malaysia Pahang (Malaysia)

Universidade da Beira Interior (Germany)
Universidade Católica Portuguesa (Portugal)
Lund University (Sweden)
More...

Package

Featured Products

More...

Oroxylin A

Catalog No: CFN98540
CAS No: 480-11-5
Price: $80/20mg

Isoquercitrin

Catalog No: CFN98753
CAS No: 482-35-9
Price: $40/20mg

Isochlorogenic acid C

Catalog No: CFN99120
CAS No: 32451-88-0
Price: $70/20mg

Astragaloside II

Catalog No: CFN99173
CAS No: 84676-89-1
Price: $50/20mg

1-Caffeoylquinic acid

Catalog No: CFN99121
CAS No: 1241-87-8
Price: $350/10mg

Alpinumisoflavone

Catalog No: CFN98440
CAS No: 34086-50-5
Price: $ /

Testosterone

Catalog No: CFN90034
CAS No: 58-22-0
Price: $40/20mg

24-Methylenecycloartan-3-ol

Catalog No: CFN99496
CAS No: 1449-09-8
Price: $ /

Hyperoside

Catalog No: CFN98754
CAS No: 482-36-0
Price: $50/20mg

Eugenol

Catalog No: CFN99175
CAS No: 97-53-0
Price: $30/20mg

Description:

Cinchonine has antiplatelet effect, mediated mainly through inhibition of Ca2+-influx and protein kinase C pathways in platelets.Dietary Cinchonine with its effects on adipogenesis and inflammation may have a potential benefit in preventing obesity. Cinchonine may be used as an anti-multidrug resistance agent.

Targets:

TLR | Calcium Channel | PKC | PARP

In vitro:

Biochem Pharmacol. 1998 Oct 15;56(8):955-60.

The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx.[Pubmed: 9776305]

The Cinchona bark contains alkaloids like quinine, quinidine, Cinchonine and cinchonidine. These agents are effective antimalarial drugs and have been used clinically in malaria caused by Plasmodium falciparum. Previous studies show that quinine and quinidine exert effects on cardiovascular system.
METHODS AND RESULTS:
This study was conducted to examine the effect of Cinchonine on human platelet aggregation. The results show that Cinchonine inhibited platelet aggregation mediated by platelet agonists, epinephrine (200 microM), ADP (4.3 microM), platelet activating factor (PAF; 800 nM) and collagen (638 nM) but had no effect on arachidonic acid (AA; 0.75 mM). Cinchonine was most effective in inhibiting aggregation induced by platelet activating factor and epinephrine with IC50 values of 125 and 180 microM respectively, however, higher concentrations of Cinchonine were required to inhibit aggregation mediated by ADP or collagen (IC50; 300 microM). Pretreatment of platelets with Cinchonine inhibited aggregation caused by Ca2+ ionophore, A-23187 (6 microM), in a dose-dependent manner (IC50; 300 microM) indicating an inhibitory effect on Ca2+-signaling cascade. This was supported by measuring [Ca2+]i in platelets loaded with Fura-2AM where Cinchonine inhibited the rise in cytosolic Ca2+ mediated by A-23187 (6 microM) or collagen (638 nM). Results show that Cinchonine (20 microM) also inhibited aggregation when platelets were pretreated with protein kinase C (PKC) activator, phorbol myristate acetate (PMA; 0.1 microM) in combination with low doses of platelet activating factor (80 nM). Cinchonine, however, had no effect on AA-induced platelet aggregation and thromboxane A2 (TXA2) synthesis in platelets.
CONCLUSIONS:
These results suggest that antiplatelet effects of Cinchonine are mediated mainly through inhibition of Ca2+-influx and protein kinase C pathways in platelets.

In vivo:

PPAR Res. 2012;2012:541204.

Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation.[Pubmed: 22675336]

Cinchonine (C(19)H(22)N(2)O) is a natural compound of Cinchona bark. Although Cinchonine's antiplatelet effect has been reported in the previous study, antiobesity effect of Cinchonine has never been studied.
METHODS AND RESULTS:
The main objective of this study was to investigate whether Cinchonine reduces high-fat-diet- (HFD-) induced adipogenesis and inflammation in the epididymal fat tissues of mice and to explore the underlying mechanisms involved in these reductions. HFD-fed mice treated with 0.05% dietary Cinchonine for 10 weeks had reduced body weight gain (-38%), visceral fat-pad weights (-26%), and plasma levels of triglyceride, free fatty acids, total cholesterol, and glucose compared with mice fed with the HFD. Moreover, Cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice. Cinchonine also attenuated the HFD-induced upregulation of proinflammatory cytokines by inhibiting toll-like-receptor-2- (TLR2-) and TLR4-mediated signaling cascades in the adipose tissue of mice.
CONCLUSIONS:

Our findings suggest that dietary Cinchonine with its effects on adipogenesis and inflammation may have a potential benefit in preventing obesity.

Cancer Res. 1992 May 15;52(10):2797-801.

Cinchonine, a potent efflux inhibitor to circumvent anthracycline resistance in vivo.[Pubmed: 1581892]

Circumvention of multidrug resistance is a new field of investigation in cancer chemotherapy, and safe and potent multidrug resistance inhibitors are needed for clinical use. We investigated several analogues of quinine for their ability to increase anthracycline uptake in resistant cancer cells. Cinchonine was the most potent inhibitor of anthracycline resistance in vitro, and its activity was little altered by serum proteins.
METHODS AND RESULTS:
Serum from rats treated with i.v. Cinchonine produced greater uptake of doxorubicin in cancer cells (DHD/K12/PROb rat colon cells and K562/ADM human leukemic cells) than did serum from quinine-treated rats (ex vivo assay). Cinchonine was more effective than quinine in reducing tumor mass and increasing the survival of rats inoculated i.p. with DHD/K12/PROb cells and treated i.p. with deoxydoxorubicin. Moreover, the acute toxicity of Cinchonine in rats and mice was lower than that of other quinine-related compounds.
CONCLUSIONS:
The lower toxicity and greater potentiation of in vivo anthracycline activity produced by Cinchonine are favorable characteristics for its use as an anti-multidrug resistance agent in future clinical trials.

Cinchonine Description

Source:	The barks of Cinchona ledgeriana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Environ Toxicol. 2011 Aug;26(4):424-31.

Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells.[Pubmed: 20196146]

Multidrug resistance (MDR) is one of important issues to cause the chemotherapy failure against cancers including gynecological malignancies. Despite some MDR reversal evidences of natural compounds including quinidine and Cinchonine, there are no reports on MDR reversal activity of hydroCinchonine with its analogues quinidine and Cinchonine especially in uterine sarcoma cells.
METHODS AND RESULTS:
Thus, in the current study, we comparatively investigated the potent efficacy of hydroCinchonine and its analogues quinidine and Cinchonine as MDR-reversal agents for combined therapy with antitumor agent paclitaxel (TAX). HydroCinchonine, Cinchonine, and quinidine significantly increased the cytotoxicity of TAX in P-glycoprotein (gp)-positive MES-SA/DX5, but not in the P-gp-negative MES-SA cells at nontoxic concentrations by 3-(4,5-dimethylthiazol-2-yl)-2,5--diphenyltetrazolium bromide (MTT) assay. Rhodamine assay also revealed that hydroCinchonine, Cinchonine, and quinidine effectively enhanced the accumulation of a P-gp substrate, rhodamine in TAX-treated MES-SA/DX5 cells compared with TAX-treated control. In addition, hydroCinchonine, Cinchonine, and quinidine effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-3, and downregulated P-gp expression as well as increased sub-G1 apoptotic portion in TAX-treated MES-SA/DX5 cells.
CONCLUSIONS:
Taken together, hydroCinchonine exerted MDR reversal activity and synergistic apoptotic effect with TAX in MES-SA/DX5 cells almost comparable with quinidine and Cinchonine as a potent MDR-reversal and combined therapy agent with TAX.

Product Name	Cinchonine
Price:	$30 / 20mg
CAS No.:	118-10-5
Catalog No.:	CFN90320
Molecular Formula:	C₁₉H₂₂N₂O
Molecular Weight:	294.39 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The barks of Cinchona ledgeriana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-platelet aggregation Compound Library Anti-adipogenic Compound Library Anti-multidrug resistance Compound Library Alkaloids Compound Library TLR Inhibitor Library PKC Inhibitor Library PARP Inhibitor Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3969 mL	16.9843 mL	33.9685 mL	67.9371 mL	84.9214 mL
5 mM	0.6794 mL	3.3969 mL	6.7937 mL	13.5874 mL	16.9843 mL
10 mM	0.3397 mL	1.6984 mL	3.3969 mL	6.7937 mL	8.4921 mL
50 mM	0.0679 mL	0.3397 mL	0.6794 mL	1.3587 mL	1.6984 mL
100 mM	0.034 mL	0.1698 mL	0.3397 mL	0.6794 mL	0.8492 mL

CFN90799	Arecoline hydrobromide	300-08-3	236.11	C₈H₁₄BrNO₂
CFN96589	Anatabine	581-49-7	160.22	C₁₀H₁₂N₂
CFN92505	Venoterpine	17948-42-4	149.2	C₉H₁₁NO
CFN90195	Quinine	130-95-0	324.42	C₂₀H₂₄N₂O₂
CFN90320	Cinchonine	118-10-5	294.39	C₁₉H₂₂N₂O
CFN70377	(+)-Dihydrocinchonine	485-65-4	296.4	C₁₉H₂₄N₂O
CFN90395	Olaquindox	23696-28-8	263.25	C₁₂H₁₃N₃O₄
CFN98040	Pedatisectine F	206757-32-6	214.2	C₉H₁₄N₂O₄
CFN99312	3-Furfuryl 2-pyrrolecarboxylate	119767-00-9	191.2	C₁₀H₉NO₃
CFN80017	3-Hydroxy-2-methylpyridine	1121-25-1	109.13	C₆H₇NO