Conicasterol | CAS:76758-18-4 | Manufacturer ChemFaces

Conicasterol

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Description:

Conicasterol displays marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with the IC50 value of 6.23 ug/mL.

In vitro:

Mar Drugs. 2016 Aug 18;14(8).

Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis.[Pubmed: 27548191 ]

METHODS AND RESULTS:
As a part of our continuing work to find out bioactive lead molecules from marine invertebrates, the CHCl₃ fraction of the organic extract of the Red Sea sponge Theonella mirabilis showed cytotoxic activity in our primary screen. Bioassay-guided purification of the active fractions of the sponge's extract resulted in the isolation of two new glycerides, mirabolides A and B (1 and 2), together with the reported 4-methylene sterols, Conicasterol (3) and swinhosterol B (4). The structures of the compounds were assigned by interpretation of their 1D (1H, (13)C), 2D (COSY, HSQC, HMBC, ROESY) NMR spectral data and high-resolution mass determinations.
CONCLUSIONS:
Compounds 1-4 displayed marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with IC50 values of 16.4, 5.18, 6.23 and 3.0 μg/mL, respectively, compared to 5.4 μg/mL observed by doxorubicin as reference drug.

Conicasterol Description

Source:	From Theonella conica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Conicasterol
Price:
CAS No.:	76758-18-4
Catalog No.:	CFN93026
Molecular Formula:	C₂₉H₄₈O
Molecular Weight:	412.70 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	From Theonella conica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4231 mL	12.1153 mL	24.2307 mL	48.4614 mL	60.5767 mL
5 mM	0.4846 mL	2.4231 mL	4.8461 mL	9.6923 mL	12.1153 mL
10 mM	0.2423 mL	1.2115 mL	2.4231 mL	4.8461 mL	6.0577 mL
50 mM	0.0485 mL	0.2423 mL	0.4846 mL	0.9692 mL	1.2115 mL
100 mM	0.0242 mL	0.1212 mL	0.2423 mL	0.4846 mL	0.6058 mL

CFN96180	Pterokaurane R	67349-43-3	322.5	C₂₀H₃₄O₃
CFN98479	Cabraleadiol 3-acetate	35833-62-6	502.8	C₃₂H₅₄O₄
CFN89023	Physcion 8-O-rutinoside	129393-21-1	592.55	C₂₈H₃₂O₁₄
CFN95339	Euphorbia factor L25	303174-98-3	538.6	C₃₁H₃₈O₈