Corynanthine | CAS:483-10-3 | Manufacturer ChemFaces

Corynanthine

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Neocryptotanshinone

Catalog No: CFN92181
CAS No: 109664-02-0
Price: $398/10mg

Ursolic acid

Catalog No: CFN97259
CAS No: 77-52-1
Price: $30/20mg

Scopoletin

Catalog No: CFN97494
CAS No: 92-61-5
Price: $30/20mg

Secoisolariciresinol

Catalog No: CFN98363
CAS No: 29388-59-8
Price: $288/10mg

Octahydrocurcumin

Catalog No: CFN90584
CAS No: 36062-07-4
Price: $388/20mg

Euphorbia factor L2

Catalog No: CFN92884
CAS No: 218916-51-9
Price: $40/20mg

Piceatannol

Catalog No: CFN99024
CAS No: 10083-24-6
Price: $40/20mg

Triptolide

Catalog No: CFN99196
CAS No: 38748-32-2
Price: $118/20mg

Lupenone

Catalog No: CFN99681
CAS No: 1617-70-5
Price: $178/20mg

8-Gingerol

Catalog No: CFN99131
CAS No: 23513-08-8
Price: $118/20mg

Description:

Corynanthine is an alpha 1-adrenoceptor and alpha 2-adrenoceptor antagonist. Corynanthine inhibits, while idazoxan potentiates, cardiotoxic effects of ouabain. It modulates DNA synthesis in mitogen-stimulated human lymphocytes.

Targets:

alpha 1-adrenoceptor | alpha 2-adrenoceptor | IL Recepter | DNA

In vitro:

Naunyn-schmiedeberg's Archives of Pharmacology, 01 Feb 1984, 325(2):136-144.

Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine.[Reference: WebLink]

In the present studies the potency and selectivity of idazoxan (RX 781094) were compared with yohimbine and its diastereoisomers rauwolscine and Corynanthine in both functional studies and radioligand binding experiments.
METHODS AND RESULTS:
Prejunctional alpha 2- and postjunctional alpha 1-adrenoceptor antagonist potencies were assessed by determining pA2 values against clonidine on the stimulated rat was deferens and noradrenaline on the anococcygeus muscle, respectively. The rank order of prejunctional alpha 2-adrenoceptor antagonist potency was idazoxan greater than yohimbine greater than rauwolscine much greater than Corynanthine. At postjunctional alpha 1-adrenoceptors the rank order of antagonist potency was rauwolscine greater than Corynanthine greater than yohimbine greater than idazoxan. The selectivity values (alpha 2/alpha 1) for idazoxan, yohimbine, rauwolscine and Corynanthine were 245, 45, 3 and 0.03 respectively. The selectivity and potency profiles established for these antagonists in functional studies were confirmed in radioligand binding studies utilising 3H-idazoxan (alpha 2) and 3H-prazosin (alpha 1) in rat cerebral cortex. In pithed rats intravenously administered idazoxan, yohimbine and rauwolscine fully reversed the inhibitory effects of clonidine on electrically-induced contractions of the vas deferens; idazoxan was approximately ten times more potent than both yohimbine and rauwolscine. Corynanthine was inactive. Idazoxan and yohimbine also fully antagonised the inhibitory effects of guanabenz on electrically-induced contractions of the anococcygeus muscle; idazoxan again was more than ten times more potent than yohimbine in this model.
CONCLUSIONS:
The inhibitory effects of guanabenz were less readily antagonised by rauwolscine indicating that the selectivity of this compound is less than that of yohimbine in this tissue. Corynanthine was again inactive.

Corynanthine Description

Source:	The herbs of Corynanthe pachyceras
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

International Journal of Immunopathology & Pharmacology, 1996, 9(2):59-65.

Reduction of mitogen-induced responsiveness of human and murine leukocytes in vitro by yohimbine and corynanthine.[Reference: WebLink]

This work was undertaken to assess the effects of yohimbine and Corynanthine firstly on the in vitro proliferation of human peripheral blood lymphocytes stimulated with various concentrations of phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM).
METHODS AND RESULTS:
Mononuclear cells were cultured in flat-bottomed 96-well microplates at 37°C for 96 (PHA and Con A) or 144 hours (PWM) in the presence of one mitogen and of one alkaloid. Concentrations of yohimbine and Corynanthine tested in cultures were 15 to 60 μg/ml and 30 to 120 μg/ml, respectively. Cell growth was measured by the incorporation of tritiated thymidine into lymphocyte DNA. We observed that both alkaloids inhibited lymphocyte DNA-synthesis in response to all mitogens. However, the effects were less pronounced when PWM was the lymphocyte stimulator, indicating that B cells are less susceptible to the drugs. Furthermore, yohimbine caused a greater inhibition than Corynanthine for a given concentration of the drugs. The alkaloids were added to cultures at different times after the beginning of the incubation period. The effect of Corynanthine occurred when the alkaloid was added during the first 24 hours of the cultures, whereas the effect of yohimbine was evident even 48 hours after addition to PHA- and Con A-stimulated lymphocyte cultures. We also tested the influence of both alkaloids (30 to 120 μg/ml) on the in vitro proliferation of murine spleen cells treated with 1% PHA and 50 μg/ml Con A and interleukin 2 (IL-2) secretion. In this case cell proliferation was assessed by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) method and IL-2 production was analysed by ELISA. Similarly to what was observed with human peripheral lymphocytes, Corynanthine and yohimbine also inhibited murine leukocyte reactivity. Furthermore, the inhibition caused by the drugs was simultaneous to a suppression of IL-2 production.
CONCLUSIONS:
The present study therefore demonstrates that the stereoisomers indole alkaloids yohimbine and Corynanthine modulate DNA synthesis in mitogen-stimulated human lymphocytes.

Animal Research:

Journal of Autonomic Pharmacology, 1995, 15(2):85-91.

Corynanthine inhibits, while idazoxan potentiates, cardiotoxic effects of ouabain.[Reference: WebLink]

1. Ouabain, infused intravenously to anaesthetized guinea-pigs induced ventricular premature beats, ventricular tachyarrhythmias and lethality.
METHODS AND RESULTS:
2. Corynanthine (1, 2 and 4 mg kg-1), an alpha 1-adrenoceptor antagonist and idazoxan (100, 200 and 400 micrograms kg-1), an alpha 2-adrenoceptor antagonist were administered 10 min prior to ouabain. Corynanthine (2 and 4 micrograms kg-1) showed significant increase in the amount of ouabain required to cause arrhythmia and lethality, whereas idazoxan (200 and 400 micrograms kg-1) decreased it. 3. Corynanthine inhibited the ouabain-induced pressor response while idazoxan potentiated it.
CONCLUSIONS:
4. Effects of these agents on the sympathetic nervous system appear to have played a significant role in its anti- and proarrhythmic actions.

Product Name	Corynanthine
Price:
CAS No.:	483-10-3
Catalog No.:	CFN70375
Molecular Formula:	C₂₁H₂₆N₂O₃
Molecular Weight:	354.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Corynanthe pachyceras
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8209 mL	14.1044 mL	28.2087 mL	56.4175 mL	70.5219 mL
5 mM	0.5642 mL	2.8209 mL	5.6417 mL	11.2835 mL	14.1044 mL
10 mM	0.2821 mL	1.4104 mL	2.8209 mL	5.6417 mL	7.0522 mL
50 mM	0.0564 mL	0.2821 mL	0.5642 mL	1.1283 mL	1.4104 mL
100 mM	0.0282 mL	0.141 mL	0.2821 mL	0.5642 mL	0.7052 mL

CFN91887	Maohuoside B	849834-04-4	838.80	C₃₉H₅₀O₂₀
CFN80253	Senkyunolide	63038-10-8	192.11	C₁₂H₁₆O₂
CFN89020	Eucamalduside A	1287220-29-4	520.53	C₂₆H₃₂O₁₁
CFN99479	Kaempferol 3,4,7-triacetate	143724-69-0	412.4	C₂₁H₁₆O₉