Science | Nature | Cell | View More
Natural Products
Crotonoside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Crotonoside
Price: $98 / 20mg
CAS No.: 1818-71-9
Catalog No.: CFN99524
Molecular Formula: C10H13N5O5
Molecular Weight: 283.24 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The seeds of Croton tiglium L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $20.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Illinois (USA)
  • Seoul National University of Sc... (Korea)
  • Korea Food Research Institute(K... (Korea)
  • University of Beira Interior (Portugal)
  • University of Fribourg (Switzerland)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Cincinnati (USA)
  • Lund University (Sweden)
  • Leibniz Institute of Plant Bioc... (Germany)
  • Mahatma Gandhi University (India)
  • Universitas islam negeri Jakarta (Indonesia)
  • More...
Package
Featured Products
Gypenoside XLIX

Catalog No: CFN99717
CAS No: 94987-08-3
Price: $118/20mg
Euphol

Catalog No: CFN89516
CAS No: 514-47-6
Price: $158/10mg
Glycerine trioleate

Catalog No: CFN90141
CAS No: 122-32-7
Price: $30/20mg
Corydaline

Catalog No: CFN90196
CAS No: 518-69-4
Price: $138/20mg
Ginsenoside Rk2

Catalog No: CFN92818
CAS No: 364779-14-6
Price: $268/5mg
Ginsenoside Rh4

Catalog No: CFN92594
CAS No: 174721-08-5
Price: $368/10mg
Feretoside

Catalog No: CFN98330
CAS No: 27530-67-2
Price: $268/10mg
Asperuloside

Catalog No: CFN99467
CAS No: 14259-45-1
Price: $118/20mg
Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg
5-Hydroxy-1,7-bis(4-hydroxyphenyl)...

Catalog No: CFN96291
CAS No: 1269839-24-8
Price: $318/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Crotonoside is one compound of an antitumor and immunity-regulating pharmaceutical composition of traditional Chinese medicine.
Targets: Adenosine Receptor
In vitro:
PAT - WO2010148577
ANTITUMOR AND IMMUNITY-REGULATING PHARMACEUTICAL COMPOSITION OF TRADITIONAL CHINESE MEDICINE, PREPARATION METHOD AND USE FOR SAME[Reference: WebLink]
An antitumor and immunity-regulating pharmaceutical composition of traditional Chinese medicine, preparation method and use for same. The pharmaceutical composition comprises Semen crotonis pulveratum, Radix Platycodi and Fritillaria with a weight ratio of 1:3:3. Semen crotonis pulveratum contains 8-12% croton oil and 1.47-5.59% Crotonoside, and is prepared by extracting croton kernel, isolating croton oil and croton dregs, and proportionately adding croton oil into croton dregs. Said composition is both curative and highly safe.
In vivo:
Arch Pharm Res. 1994 Apr;17(2):115-8.
Isolation of isoguanosine from Croton tiglium and its antitumor activity.[Pubmed: 10319142]
This paper describes the isolation of isoguanosine(Crotonoside) from Croton tiglium L. and its cytotoxic effect against several tumor cell lines in culture and newly reports that isoguanosine(Crotonoside) has an antitumor activity against implanted S-180 ascitic tumor mice.
METHODS AND RESULTS:
Isoguanosine is effective at the dose of 24 mg/kg/day x 5, with T/C value of 168%. Isoguanosine inhibits the growth of S-180 and Ehrlich solid tumor in mice at the optimal doses of 96 mg/kg/day x 12 and 48 mg/kg/day x 12, with 1-T/C values of 65% and 60%, respectively.
Crotonoside Description
Source: The seeds of Croton tiglium L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Safflospermidine B

Catalog No: CFN95254
CAS No: 1111082-11-1
Price: $413/5mg
Emodin-8-O-beta-gentiobioside

Catalog No: CFN95132
CAS No: 66466-22-6
Price: $368/5mg
(R)-Reticuline

Catalog No: CFN95013
CAS No: 3968-19-2
Price: $/mg
4-Methoxybenzoylacetic acid

Catalog No: CFN95446
CAS No: 13422-77-0
Price: $318/5mg
Quercetin 3,5-O-diglucoside

Catalog No: CFN95486
CAS No: 206257-35-4
Price: $368/10mg
Symplocoside

Catalog No: CFN95552
CAS No: 76502-76-6
Price: $318/5mg
ZP-amide C

Catalog No: CFN95362
CAS No: 412316-38-2
Price: $318/5mg
Clemastanin B

Catalog No: CFN95064
CAS No: 112747-98-5
Price: $368/20mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5306 mL 17.6529 mL 35.3057 mL 70.6115 mL 88.2644 mL
5 mM 0.7061 mL 3.5306 mL 7.0611 mL 14.1223 mL 17.6529 mL
10 mM 0.3531 mL 1.7653 mL 3.5306 mL 7.0611 mL 8.8264 mL
50 mM 0.0706 mL 0.3531 mL 0.7061 mL 1.4122 mL 1.7653 mL
100 mM 0.0353 mL 0.1765 mL 0.3531 mL 0.7061 mL 0.8826 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Phys Chem A. 2013 Jul 18;117(28):5715-25.
Mechanism of the deamination reaction of isoguanine: a theoretical investigation.[Pubmed: 23789717]

METHODS AND RESULTS:
Mechanisms of the deamination reactions of isoguanine (Crotonoside) with H2O, OH(-), and OH(-)/H2O and of protonated isoguanine (isoGH(+)) with H2O have been investigated by theoretical calculations. Eight pathways, paths A-H, have been explored and the thermodynamic properties (ΔE, ΔH, and ΔG), activation energies, enthalpies, and Gibbs energies of activation were calculated for each reaction investigated. Compared with the deamination reaction of isoguanine or protonated isoguanine (isoGH(+)) with water, the deamination reaction of isoguanine with OH(-) shows a lower Gibbs energy of activation at the rate-determining step, indicating that the deamination reaction of isoguanine is favorably to take place for the deprotonated form isoG(-) with water.
CONCLUSIONS:
With the assistance of an extra water, the reaction of isoguanine with OH(-)/H2O, pathways F and H, are found to be the most feasible pathways in aqueous solution due to their lowest Gibbs energy of activation of 174.7 and 172.6 kJ mol(-1), respectively, at the B3LYP/6-311++G(d,p) level of theory.
Biochemistry. 1994 Oct 11;33(40):12119-26.
Isoguanosine substitution of conserved adenosines in the hammerhead ribozyme.[Pubmed: 7918433]

METHODS AND RESULTS:
Isoguanosine(Crotonoside) has been incorporated into a 34-mer hammerhead ribozyme by the solid-phase phosphoramidite method, using an acetamidine base protecting group. The activity of the hammerhead ribozyme when singly mutated to isoguanosine at the adenosine positions 6, 9, and 13 was 1-2-fold less than the wild-type activity. Mutations to 2-aminopurine ribonucleoside at positions 9 and 13 were 5-fold reduced in activity, but that at position 6 was approximately 30-fold reduced.
CONCLUSIONS:
These results support the view that the 6-amino functions of A6, A9, and A13 are not very important for catalysis. The 2-position of A6 tolerates a carbonyl function but not an amino group, whereas A9 and A13 tolerate both functional groups. The tolerance of a 2-amino group at A9 and A13 makes G(anti)/A(anti) Watson-Crick type base mispairing for G12/A9 and A13/G8 unlikely.
Gypenoside XLIX

Catalog No: CFN99717
CAS No: 94987-08-3
Price: $118/20mg
Euphol

Catalog No: CFN89516
CAS No: 514-47-6
Price: $158/10mg
Glycerine trioleate

Catalog No: CFN90141
CAS No: 122-32-7
Price: $30/20mg
Corydaline

Catalog No: CFN90196
CAS No: 518-69-4
Price: $138/20mg
Ginsenoside Rk2

Catalog No: CFN92818
CAS No: 364779-14-6
Price: $268/5mg
Ginsenoside Rh4

Catalog No: CFN92594
CAS No: 174721-08-5
Price: $368/10mg
Feretoside

Catalog No: CFN98330
CAS No: 27530-67-2
Price: $268/10mg
Asperuloside

Catalog No: CFN99467
CAS No: 14259-45-1
Price: $118/20mg
Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg
5-Hydroxy-1,7-bis(4-hydroxyphenyl)...

Catalog No: CFN96291
CAS No: 1269839-24-8
Price: $318/10mg
Tags: buy Crotonoside | Crotonoside supplier | purchase Crotonoside | Crotonoside cost | Crotonoside manufacturer | order Crotonoside | Crotonoside distributor