Ginsenoside Rh4 | CAS:174721-08-5 | Manufacturer ChemFaces

Ginsenoside Rh4

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Size /Price /Stock	10 mM * 1 mL in DMSO / $211.7 / In-stock
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Description:

Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy. Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect; it has cytotoxic activity and its aglycone against cancer cell lines.

Targets:

Caspase | Autophagy | Bcl-2/Bax

In vivo:

Chem Biodivers. 2007 Feb;4(2):232-40.

Immunological adjuvant effect of ginsenoside Rh4 from the roots of Panax notoginseng on specific antibody and cellular response to ovalbumin in mice.[Pubmed: 17311234]

METHODS AND RESULTS:
Ginsenoside Rh4 (1), a saponin isolated from the roots of Panax notoginseng (Burk.) F. H. Chen, was evaluated for its haemolytic activity and adjuvant potential on specific antibody and cellular response to ovalbumin (OVA) in mice. Compound 1 showed a slight haemolytic effect, its concentration inducing 50% of the maximum haemolysis (HD(50) value) being 407+/-12 microg/ml using a 0.5% suspension of red blood cells. Ginsenoside Rh4 significantly increased the concanavalin A (Con A)-, lipopolysaccharide (LPS)-, and OVA-induced splenocyte proliferation in OVA-immunized mice especially at a dose of 25 microg (P<0.05, P<0.01, or P<0.001). The OVA-specific serum IgG, IgG1, and IgG2b antibody levels were also significantly enhanced by 1 at a dose of 25 microg compared to the OVA control group (P<0.05 or P<0.01). Moreover, the enhancing effect of Ginsenoside Rh4 on the OVA-specific IgG2b antibody responses to OVA in mice was more significant than that of Alum (Al(OH)(3) gel; P<0.01).
CONCLUSIONS:
These results suggest that Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect.

Ginsenoside Rh4 Description

Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Ginsenoside Rh4
Price:	$368 / 10mg
CAS No.:	174721-08-5
Catalog No.:	CFN92594
Molecular Formula:	C₃₆H₆₀O₈
Molecular Weight:	620.9 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Hemolytic Compound Library Nephroprotective Compound Library Triterpenoids Compound Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library Autophagy Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6106 mL	8.0528 mL	16.1057 mL	32.2113 mL	40.2641 mL
5 mM	0.3221 mL	1.6106 mL	3.2211 mL	6.4423 mL	8.0528 mL
10 mM	0.1611 mL	0.8053 mL	1.6106 mL	3.2211 mL	4.0264 mL
50 mM	0.0322 mL	0.1611 mL	0.3221 mL	0.6442 mL	0.8053 mL
100 mM	0.0161 mL	0.0805 mL	0.1611 mL	0.3221 mL	0.4026 mL

CFN95845	Notoginsenoside SFt4	1351360-30-9	899.1	C₄₇H₇₈O₁₆
CFN91838	Damulin A	1202868-74-3	783.0	C₄₂H₇₀O₁₃
CFN91837	Damulin B	1202868-75-4	783.0	C₄₂H₇₀O₁₃
CFN92593	Ginsenoside Rk3	364779-15-7	620.9	C₃₆H₆₀O₈
CFN90565	Ginsenoside Rg6	147419-93-0	766.5	C₄₂H₇₀O₁₂
CFN92594	Ginsenoside Rh4	174721-08-5	620.9	C₃₆H₆₀O₈
CFN90572	Ginsenoside Rg4	126223-28-7	767.0	C₄₂H₇₀O₁₂
CFN99477	3-Acetoxy-24-hydroxydammara-20,25-diene	143519-04-4	484.8	C₃₂H₅₂O₃
CFN92818	Ginsenoside Rk2	364779-14-6	604.9	C₃₆H₆₀O₇
CFN92644	Ginsenoside Rk1	494753-69-4	767.0	C₄₂H₇₀O₁₂