Cucurbitacin A | CAS:6040-19-3 | Manufacturer ChemFaces

Cucurbitacin A

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Description:

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

Targets:

ROCK

In vitro:

Biochem. Pharmacol., 2015, 102:45-63.

Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase.[Pubmed: 26707799 ]

Cucurbitacins are cytotoxic triterpenoid sterols isolated from plants. One of their earliest cellular effect is the aggregation of actin associated with blockage of cell migration and division that eventually lead to apoptosis.
METHODS AND RESULTS:
We unravel here that cucurbitacin I actually induces the co-aggregation of actin with phospho-myosin II. This co-aggregation most probably results from the stimulation of the Rho/ROCK pathway and the direct inhibition of the LIMKinase. We further provide data that suggest that the formation of these co-aggregates is independent of a putative pro-oxidant status of cucurbitacin I.
CONCLUSIONS:
The results help to understand the impact of cucurbitacins on signal transduction and actin dynamics and open novel perspectives to use it as drug candidates for cancer research.

Cucurbitacin A Description

Source:	The rhizomes of Hemsleya amabilis Diels.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cucurbitacin A
Price:
CAS No.:	6040-19-3
Catalog No.:	CFN90324
Molecular Formula:	C₃₂H₄₆O₉
Molecular Weight:	574.71 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The rhizomes of Hemsleya amabilis Diels.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Toxicity Compound Library Triterpenoids Compound Library ROCK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.74 mL	8.7 mL	17.4001 mL	34.8002 mL	43.5002 mL
5 mM	0.348 mL	1.74 mL	3.48 mL	6.96 mL	8.7 mL
10 mM	0.174 mL	0.87 mL	1.74 mL	3.48 mL	4.35 mL
50 mM	0.0348 mL	0.174 mL	0.348 mL	0.696 mL	0.87 mL
100 mM	0.0174 mL	0.087 mL	0.174 mL	0.348 mL	0.435 mL

CFN92892	Tetrahydroisocucurbitacin I	3877-89-2	518.68	C₃₀H₄₆O₇
CFN98171	Cucurbitacin IIA	58546-34-2	562.73	C₃₂H₅₀O₈
CFN91760	Cucurbitacin Q1	99530-82-2	560.72	C₃₂H₄₈O₈
CFN92895	Cucurbitacin R	55903-92-9	518.68	C₃₀H₄₆O₇
CFN92140	Dihydrocucurbitacin B	13201-14-4	560.7	C₃₂H₄₈O₈
CFN91586	Fabacein	37710-13-7	600.7	C₃₄H₄₈O₉
CFN92896	Arvenin II	65247-28-1	722.86	C₃₈H₅₈O₁₃
CFN95327	Arvenin III	65597-45-7	678.8	C₃₆H₅₄O₁₂
CFN92893	Hexanorcucurbitacin D	29065-05-2	402.52	C₂₄H₃₄O₅
CFN90209	Cucurbitacin D	3877-86-9	516.67	C₃₀H₄₄O₇