Dehydrodicentrine | CAS:19843-03-9 | Manufacturer ChemFaces

Dehydrodicentrine

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Description:

Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.

Targets:

AChR

In vitro:

Fitoterapia. 2015 Jul;104:102-7.

Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea.[Pubmed: 26028544]

METHODS AND RESULTS:
An unusual proaporphine alkaloid bearing an isopropanenitrile group at isoquinoline nitrogen, named epiganine A (1) and a new aporphine alkaloid, epiganine B (2), together with eight known alkaloids, pronuciferine (3), Dehydrodicentrine (4), romerine (5), romeline (6), N-methylcalycinine (7), phanostenine (8), dicentrine (9), and N-methyllaurotetanine (10), were isolated from the roots of Stephania epigaea. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD) and comparing with experimental data.
CONCLUSIONS:
Compounds 2 and 4 showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 values of 4.36 and 2.98μM, respectively. Compounds 5-9 also exhibited potent AChE inhibitory activities.

Dehydrodicentrine Description

Source:	The roots of Stephania delavayi Diels
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Dehydrodicentrine
Price:
CAS No.:	19843-03-9
Catalog No.:	CFN93312
Molecular Formula:	C₂₀H₁₉NO₄
Molecular Weight:	337.37 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Stephania delavayi Diels
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9641 mL	14.8205 mL	29.641 mL	59.2821 mL	74.1026 mL
5 mM	0.5928 mL	2.9641 mL	5.9282 mL	11.8564 mL	14.8205 mL
10 mM	0.2964 mL	1.4821 mL	2.9641 mL	5.9282 mL	7.4103 mL
50 mM	0.0593 mL	0.2964 mL	0.5928 mL	1.1856 mL	1.4821 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	0.5928 mL	0.741 mL

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