Delphinidin-3-O-sambubioside-5-O-glucoside chloride | CAS:36415-91-5

Delphinidin-3-O-sambubioside-5-O-glucoside chloride

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Description:

Delphinidin-3-O-sambubioside-5-O-glucoside chloride suppresses the light-induced photoreceptor cell death by inhibiting ROS production, suggesting that the inhibition of phosphorylated-p38 may be involved in the underlying mechanism.

Targets:

ROS | p38

In vitro:

Food Chemistry, 2013, 139(1-4):129-137.

Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light.[Pubmed: 23561088]

METHODS AND RESULTS:
The protective effects of maqui berry (Aristotelia chilensis) extract (MBE) and its major anthocyanins [delphinidin 3,5-O-diglucoside (D3G5G) and delphinidin 3-O-sambubioside-5-O-glucoside (Delphinidin-3-O-sambubioside-5-O-glucoside chloride ,D3S5G)] against light-induced murine photoreceptor cells (661W) death were evaluated. Viability of 661W after light treatment for 24 h, assessed by the tetrazolium salt (WST-8) assay and Hoechst 33342 nuclear staining, was improved by addition of MBE, D3G5G, and D3S5G. Intracellular radical activation in 661W, evaluated using the reactive oxygen species (ROS)-sensitive probe 5-(and-6)-chloromethyl-2,7-dichlorodihydro fluorescein diacetate acetyl ester (CM-H2DCFDA), was reduced by MBE and its anthocyanins. The anti-apoptosis mechanism of MBE was evaluated by light-induced phosphorylation of p38. MBE significantly suppressed the light-induced phosphorylation of p38.
CONCLUSIONS:
These findings indicate that MBE and its anthocyanidins suppress the light-induced photoreceptor cell death by inhibiting ROS production, suggesting that the inhibition of phosphorylated-p38 may be involved in the underlying mechanism.

Delphinidin-3-O-sambubioside-5-O-glucoside chloride Description

Source:	The fruits of Vaccinium myrtillus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Delphinidin-3-O-sambubioside-5-O-glucoside chloride
Price:	$318 / 5mg
CAS No.:	36415-91-5
Catalog No.:	CFN91870
Molecular Formula:	C₃₂H₃₉ClO₂₁
Molecular Weight:	795.1 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The fruits of Vaccinium myrtillus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library ROS Inhibitor Library p38 Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2577 mL	6.2885 mL	12.577 mL	25.1541 mL	31.4426 mL
5 mM	0.2515 mL	1.2577 mL	2.5154 mL	5.0308 mL	6.2885 mL
10 mM	0.1258 mL	0.6289 mL	1.2577 mL	2.5154 mL	3.1443 mL
50 mM	0.0252 mL	0.1258 mL	0.2515 mL	0.5031 mL	0.6289 mL
100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.2515 mL	0.3144 mL

CFN92170	Pelargonidin-3,5-O-diglucoside chloride	17334-58-6	631.0	C₂₇H₃₁O₁₅Cl
CFN92133	Pelargonidin-3-O-rutinoside chloride	33978-17-5	615.0	C₂₇H₃₁O₁₄Cl
CFN91858	Luteolinidin chloride	1154-78-5	306.7	C₁₅H₁₁ClO₅
CFN91863	Apigeninidin chloride	1151-98-0	290.7	C₁₅H₁₁ClO₄
CFN91861	Fisetinidin chloride	2948-76-7	306.7	C₁₅H₁₁ClO₅
CFN91856	Robinetinidin chloride	3020-09-5	322.7	C₁₅H₁₁ClO₆
CFN92038	Delphinidin-3-O-glucoside chloride	6906-38-3	500.8	C₂₁H₂₁ClO₁₂
CFN92037	Delphinidin-3-O-galactoside chloride	28500-00-7	500.8	C₂₁H₂₁ClO₁₂
CFN92171	Delphinidin-3-sambubioside chloride	53158-73-9	633.0	C₂₆H₂₉O₁₆Cl
CFN92136	Delphinidin-3-O-rutinoside chloride	15674-58-5	645.0	C₂₇H₃₁O₁₆Cl