Dimethylcurcumin | CAS:52328-98-0 | Manufacturer ChemFaces

Dimethylcurcumin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $49.6 / In-stock
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Description:

Dimethylcurcumin is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion.

Targets:

Androgen Receptor

In vitro:

Mol Nutr Food Res. 2008 Sep;52(9):1005-9.

Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research.[Pubmed: 18186103]

METHODS AND RESULTS:
The ability of the curry constituent curcumin to delay the onset of cancer has been the topic of extensive research for many years. Abundant literature is devoted to mechanisms by which curcumin may mediate this activity. These insights have prompted investigations in which curcumin as lead molecule serves as a scaffold for synthetic chemical attempts to optimize pharmacological potency. Among the published analogues with notable efficacy are Dimethylcurcumin, 1,5-bis(3-pyridyl)-1,4-pentadien-3-one and 3,5-bis-(2-fluorobenzylidene)-piperidinium-4-one acetate. Results of a small number of clinical pilot studies conducted with curcumin at doses of up to 12 g suggest tentatively that it is safe in humans.
CONCLUSIONS:
Prevention of adenoma recurrence constitutes a clinical paradigm worthy of further investigation for curcumin. Future clinical study should include measurement of mechanism-based pharmacodynamic parameters.

Dimethylcurcumin Description

Source:	The rhizomes of Curcuma rcenyujin.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Dimethylcurcumin
Price:	$218 / 20mg
CAS No.:	52328-98-0
Catalog No.:	CFN90607
Molecular Formula:	C₂₃H₂₄O₆
Molecular Weight:	396.43 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The rhizomes of Curcuma rcenyujin.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-androgen receptor Compound Library Phenols Compound Library Androgen Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5225 mL	12.6126 mL	25.2251 mL	50.4503 mL	63.0628 mL
5 mM	0.5045 mL	2.5225 mL	5.045 mL	10.0901 mL	12.6126 mL
10 mM	0.2523 mL	1.2613 mL	2.5225 mL	5.045 mL	6.3063 mL
50 mM	0.0505 mL	0.2523 mL	0.5045 mL	1.009 mL	1.2613 mL
100 mM	0.0252 mL	0.1261 mL	0.2523 mL	0.5045 mL	0.6306 mL

CFN95475	Malabaricone C	63335-25-1	358.4	C₂₁H₂₆O₅
CFN95481	Giganteone A	460337-13-7	714.9	C₄₂H₅₀O₁₀
CFN95484	Giganteone C	1071223-56-7	698.9	C₄₂H₅₀O₉
CFN95483	Maingayone B	1071223-57-8	684.9	C₄₂H₅₂O₈
CFN95479	Maingayone	271585-66-1	700.9	C₄₂H₅₂O₉
CFN95809	New compound 40	N/A	710.9	C₄₄H₅₄O₈
CFN95103	Cyclocurcumin	153127-42-5	368.4	C₂₁H₂₀O₆
CFN95857	1,5-Epoxy-3R-hydroxy-1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane	182227-93-6	390.4	C₂₁H₂₆O₇
CFN95858	1,5-Epoxy-3S-hydroxy-1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane	182369-54-6	364.4	C₂₀H₂₈O₆
CFN89281	4'-O-Methylnyasol	79004-25-4	266.34	C₁₈H₁₈O₂