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Discodermide
Discodermide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Discodermide
Price:
CAS No.: 134458-00-7
Catalog No.: CFN00114
Molecular Formula: C27H34N2O6
Molecular Weight: 482.58 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Discodermia dissoluta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Discodermide has antifungal and cytotoxic activities.
Targets: Antifection
Discodermide Description
Source: From Discodermia dissoluta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0722 mL 10.361 mL 20.722 mL 41.4439 mL 51.8049 mL
5 mM 0.4144 mL 2.0722 mL 4.1444 mL 8.2888 mL 10.361 mL
10 mM 0.2072 mL 1.0361 mL 2.0722 mL 4.1444 mL 5.1805 mL
50 mM 0.0414 mL 0.2072 mL 0.4144 mL 0.8289 mL 1.0361 mL
100 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.4144 mL 0.518 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J. Org. Chem., 1991, 56(16):4833-40
Discodermide: A new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta[Reference: WebLink]

METHODS AND RESULTS:
A new macrocyclic lactam, Discodermide (1), was isolated from a Caribbean marine sponge, Discodermia dissoluta. Its structure was elucidated through a combination of spectroscopic techniques, in particular NMR spectroscopy.
CONCLUSIONS:
The carbon skeleton displayed by Discodermide is new; Discodermide is antifungal and cytotoxic.
CFN00090Panamycin 607100905-89-3607.86C35H61NO7
CFN00101Aburatubolactam A170894-24-3508.66C30H40N2O5
CFN00103Altamycin A60202-22-4561.67C30H43NO9
CFN00112Cylindramide147362-39-8466.57C27H34N2O5
CFN00114Discodermide134458-00-7482.58C27H34N2O6
CFN00126Antibiotic BU 2313A69774-86-3517.57C27H35NO9
CFN00144Xanthobaccin A227596-81-8510.63C29H38N2O6
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