Rhaponiticin | CAS:155-58-8 | Manufacturer ChemFaces

Rhaponiticin

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Size /Price /Stock	10 mM * 1 mL in DMSO / $16.9 / In-stock
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Description:

Rhaponticin(Rhaponiticin) has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications, it can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice.

Targets:

LDL

In vivo:

Planta Med. 2009 Apr;75(5):472-7.

Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice.[Pubmed: 19235684]

We isolated several stilbene compounds including rhaponticin (Rhaponiticin,3',5-dihydroxy-4'-methoxystilbene 3- O-beta- D-glucopyranoside) from extracts of rhubarb rhizomes. These compounds showed significant hypoglycemic effects in streptozotocin (STZ)-induced type 1 diabetic rats and mice.
METHODS AND RESULTS:
In this study, we investigated the effect of rhaponticin on glucose utilization, lipid metabolism, and liver and heart function in a KK/Ay type 2 diabetic mouse model. The results showed that oral administration of rhaponticin (125 mg/kg) significantly reduced blood glucose levels and improved oral glucose tolerance of KK/Ay diabetic mice. Elevated plasma triglyceride (TG), low density lipoprotein (LDL), cholesterol (CHO), non-esterified free fatty acids (NEFA), and insulin levels were also markedly attenuated. Serum enzymatic activities of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the rhaponticin-treated group significantly decreased in comparison to the untreated model group. Livers of rhaponticin-treated mice had relatively normal cellular size and decreased fibrosis and steatosis. In addition, rhaponticin administration caused a remarkable increase in the hepatic glycogen content and a significant reduction in the hepatic triglyceride content.
CONCLUSIONS:
These results indicate that rhaponticin has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications.

Rhaponiticin Description

Source:	The roots of Rumex obtusifolius L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Rhaponiticin
Price:	$60 / 20mg
CAS No.:	155-58-8
Catalog No.:	CFN98569
Molecular Formula:	C₂₁H₂₄O₉
Molecular Weight:	420.39 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Rumex obtusifolius L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-diabetic Compound Library Anti-diabetic complications Compound Library Phenols Compound Library LDL Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3787 mL	11.8937 mL	23.7874 mL	47.5749 mL	59.4686 mL
5 mM	0.4757 mL	2.3787 mL	4.7575 mL	9.515 mL	11.8937 mL
10 mM	0.2379 mL	1.1894 mL	2.3787 mL	4.7575 mL	5.9469 mL
50 mM	0.0476 mL	0.2379 mL	0.4757 mL	0.9515 mL	1.1894 mL
100 mM	0.0238 mL	0.1189 mL	0.2379 mL	0.4757 mL	0.5947 mL

CFN99586	Mulberroside A	102841-42-9	568.52	C₂₆H₃₂O₁₄
CFN95006	cis-Mulberroside A	166734-06-1	568.52	C₂₆H₃₂O₁₄
CFN92443	Gnetucleistol D	629643-26-1	258.3	C₁₅H₁₄O₄
CFN92425	Gnetol	86361-55-9	244.2	C₁₄H₁₂O₄
CFN92678	Gnetucleistol B	864763-60-0	274.3	C₁₅H₁₄O₅
CFN90811	Salvianolic acid F	158732-59-3	314.3	C₁₇H₁₄O₆
CFN92426	Isorhapotogenin	32507-66-7	258.3	C₁₅H₁₄O₄
CFN97824	Tristin	139101-67-0	260.29	C₁₅H₁₆O₄
CFN92607	Rhapontigenin	500-65-2	258.3	C₁₅H₁₄O₄
CFN98569	Rhaponiticin	155-58-8	420.39	C₂₁H₂₄O₉