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Erysotrine
Erysotrine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Erysotrine
Price:
CAS No.: 27740-43-8
Catalog No.: CFN98336
Molecular Formula: C19H23NO3
Molecular Weight: 313.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source: The barks of Aralia chinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Erysotrine does not show cytotoxic activity by itself, but exhibits significant cytotoxicity when combines with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). (+)-Erysotrine shows potent dosedependant antifeedant activity at concentrations ≥100 ppm.
Targets: AChR
In vitro:
Nat Prod Res. 2012;26(17):1565-75.
Anti-HIV-1 and cytotoxicity of the alkaloids of Erythrina abyssinica Lam. growing in Sudan.[Pubmed: 21936641]
Erythrina abyssinica Lam. is an important medicinal plant growing in Sudan; its seeds were investigated for the first time for their alkaloidal constituents and biological activity.
METHODS AND RESULTS:
The in vitro cytotoxicity of the crude alkaloidal fraction (CAF) against the cell lines HeLa, Hep-G2, HEP-2, HCT116, MCF-7 and HFB4 showed promising activity, with IC₅₀ values of 13.8, 10.1, 8.16, 13.9, 11.4 and 12.2 µg mL⁻¹, respectively. Doxorubicin (positive control) showed in vitro cytotoxic activity with IC₅₀ values 3.64, 4.57, 4.89, 3.74, 2.97 and 3.96 µg mL⁻¹, respectively. Bioassay-guided fractionation and isolation of the CAF led to the isolation of five Erythrina alkaloids, identified as erythraline, erysodine, Erysotrine, 8-oxoerythraline and 11-methoxyerysodine. These were evaluated for their in vitro cytotoxic activity against Hep-G2 which resulted in IC₅₀ values 17.60, 11.80, 15.80, 3.89 and 11.40 µg mL⁻¹, respectively. Furthermore, in vitro cytotoxic activity against HEP-2 was evaluated, which resulted in IC₅₀ values 15.90, 19.90, 21.60, 18.50 and 11.50 µg mL⁻¹, respectively. The CAF caused a reduction in the viability of mock-infected MT-4 cells with a CC₅₀ of 53 µM and a 50% protection of MT-4 cells against HIV-1 induced cytopathogeneticy with a EC₅₀ of >53 µM, compared with EFV as a positive control, which had a CC₅₀ of 45 µM and an EC₅₀ of 0.003 µM.
CONCLUSIONS:
We concluded that the isolated alkaloids were responsible for the anti-carcinogenic [corrected] actions of the plant extract previously reported in the literature..
Records of Natural Products,2009, 3(2):96-103.
Antifeedant activities of the erythrinaline alkaloids from Erythrina latissima against Spodoptera littoralis (Lepidoptera noctuidae).[Reference: WebLink]

METHODS AND RESULTS:
The antifeedant activities of the Erythrina alkaloids from the seeds, seed pods and flowers ofErythrina latissima were investigated in laboratory dual- choice bioassays using third-instar Spodoptera littoralis(Boisduval) larvae. The new compound (+)-11-methoxy-10-oxoerysotramidine (1) from the flowers, showedpotent dose dependant activity at concentration ≥ 500 ppm while (+)-10,11-dioxoerysotramidine (2) also newfrom the flowers showed potent dose dependant activity at concentration ≥100 ppm. Three known compounds(+)-Erysotrine, (+)-erysotramidine, (+)-erythraline, (+)-11-hydroxyerysotramidine showed potent dosedependant antifeedant activity at concentrations ≥100 ppm while (+)-10,11-dioxoErysotrine and (+)-11b-hydroxyerysotramidine also a known compounds showed potent dose dependant antifeedant activity atconcentrations ≥300 ppm.
CONCLUSIONS:
Three known compounds (+)-11-methoxyerysotramidine, (+)-8-oxoerythralineand (+)-15(16)b-D-glucoerysodine showed no appreciable change in antifeedant activity with concentrationchange.
Erysotrine Description
Source: The barks of Aralia chinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1908 mL 15.9541 mL 31.9081 mL 63.8162 mL 79.7703 mL
5 mM 0.6382 mL 3.1908 mL 6.3816 mL 12.7632 mL 15.9541 mL
10 mM 0.3191 mL 1.5954 mL 3.1908 mL 6.3816 mL 7.977 mL
50 mM 0.0638 mL 0.3191 mL 0.6382 mL 1.2763 mL 1.5954 mL
100 mM 0.0319 mL 0.1595 mL 0.3191 mL 0.6382 mL 0.7977 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Bioorg Med Chem Lett. 2009 Jan 1;19(1):234-6.
TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina.[Pubmed: 19026536 ]

METHODS AND RESULTS:
A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2-7, 9) and an indole alkaloid (8). The structure of new compound (1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
CONCLUSIONS:
Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.
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