| In vitro: |
| Arch Pharm Res. 2006 Sep;29(9):741-5. | | Estrogenic activity of furanocoumarins isolated from Angelica dahurica.[Pubmed: 17024846] |
METHODS AND RESULTS:
In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and Alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 microg/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active. | | J Ethnopharmacol. 2004 Aug;93(2-3):243-6. | | Antioxidative activity of furanocoumarins isolated from Angelicae dahuricae.[Pubmed: 15234759 ] |
METHODS AND RESULTS:
The methylene chloride extract of the root of Angelicae dahuricae showed high protective activity against 2,2'-azobis (2-aminodinopropane) dihydrochloride (AAPH)-induced cellular damage. From this extract, 11 furanocoumarins were isolated, namely oxypeucedanin hydrate, 9-hydroxy-4-methoxypsoralen, byakangelicin, pabulenol, Alloisoimperatorin, neobyakangelicol, byakangelicol, oxypeucedanin, imperatorin, phellotorin and isoimperatorin, respectively.
CONCLUSIONS:
Among these 11 furanocoumarins, 9-hydroxy-4-methoxypsoralen and Alloisoimperatorin displayed potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. |
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