Eupalinolide O | CAS:2170228-67-6 | Manufacturer ChemFaces

Eupalinolide O

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Size /Price /Stock	10 mM * 1 mL in DMSO / $218 / In-stock
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Description:

Eupalinolide O shows significant anticancer activity, it induces cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells.

Targets:

Akt

In vitro:

Nat Prod Res,2019 Feb;33(4):477-485.

Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer.[Pubmed: 29086600]

Michael reaction acceptors (MRAs) are a class of active compounds. There is a great prospect to screen STAT3 inhibitors from Eupatorium lindleyanum, furthermore, to discover lead compounds for anti-triple-negative breast cancer (TNBC).
METHODS AND RESULTS:
In this study, glutathione (GSH) was employed, and a UPLC-MS screening method was developed to discover MRAs. We screened MRAs which can inhibit STAT3 using a STAT3-dependent reporter system. Six sesquiterpene lactones, including a new compound Eupalinolide O (1), together with five known compounds, Eupalinolide I (2), Eupalinolide K (3), Eupalinolide H (4), Eupalinolide J (5) and Eupalinolide G (6) were isolated. Eupalinolide J was identified as MRA that decreased luciferase activity of STAT3. Preliminary activity assessment showed that Eupalinolide J could inhibit the viability of TNBC cell lines.
CONCLUSIONS:
We demonstrated that Eupalinolide J, which is a natural typical MRA, has a notable inhibition of STAT3 activity and a potential cytotoxic activity against TNBC cell lines.

Eupalinolide O Description

Source:	The herbs of Eupatorium lindleyanum DC.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Bioorg. Med. Chem.,2011 Nov 1;19(21):6254-60.

Eupalinolide O, a novel sesquiterpene lactone from Eupatorium lindleyanum DC., induces cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells.[Reference: WebLink]

Sesquiterpene lactones have been confirmed to have potential antitumor activity.
METHODS AND RESULTS:
Here, we demonstrated that Eupalinolide O (EO), a novel sesquiterpene lactone isolated from Eupatorium lindleyanum DC., showed significant anticancer activity against human MDA-MB-468 breast cancer cells. The cytotoxicity induced by EO was mediated by induction of apoptosis. Flow cytometric analysis demonstrated that EO treatment resulted in loss of the mitochondrial membrane potential in cancer cells which is regarded as a hallmark of apoptosis. Further study demonstrated that EO induced apoptotic cell death in the MDA-MB-468 cells through the activation of caspases. The effect of EO on the induction of apoptosis was significantly prevented by the treatment of pan-caspase inhibitor Z-VAD-FMK. We also found that EO treatment resulted in cell cycle arrest in the G2/M phase. The expression of cell cycle-related proteins (cyclin B1 and cdc2) was significantly decreased. Furthermore, the suppression of the Akt pathway in the MDA-MB-468 cells was observed.
CONCLUSIONS:
Collectively, EO suppressed the growth of the MDA-MB‑468 cells possibly by cell cycle arrest in the G2/M phase and the induction of caspase-dependent apoptosis. These results suggest that EO is a promising natural compound for breast cancer therapy.

Product Name	Eupalinolide O
Price:	$218 / 5mg
CAS No.:	2170228-67-6
Catalog No.:	CFN91839
Molecular Formula:	C₂₂H₂₆O₈
Molecular Weight:	418.4 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Eupatorium lindleyanum DC.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3901 mL	11.9503 mL	23.9006 mL	47.8011 mL	59.7514 mL
5 mM	0.478 mL	2.3901 mL	4.7801 mL	9.5602 mL	11.9503 mL
10 mM	0.239 mL	1.195 mL	2.3901 mL	4.7801 mL	5.9751 mL
50 mM	0.0478 mL	0.239 mL	0.478 mL	0.956 mL	1.195 mL
100 mM	0.0239 mL	0.1195 mL	0.239 mL	0.478 mL	0.5975 mL

CFN99286	Carabrolactone A	1187925-30-9	282.3	C₁₅H₂₂O₅
CFN97438	11(13)-Dehydroivaxillin	87441-73-4	264.3	C₁₅H₂₀O₄
CFN92791	Aeruginolactone	1005208-88-7	248.3	C₁₅H₂₀O₃
CFN91839	Eupalinolide O	2170228-67-6	418.4	C₂₂H₂₆O₈
CFN90381	Eupalinolide A	877822-41-8	462.49	C₂₄H₃₀O₉
CFN90382	Eupalinolide B	877822-40-7	462.49	C₂₄H₃₀O₉
CFN99435	Eupalinolide K	108657-10-9	362.4	C₂₀H₂₆O₆
CFN92956	4,15-Isoatriplicolide methylacrylate	133559-38-3	344.36	C₁₉H₂₀O₆
CFN92955	Isoatriplicolide tiglate	133559-39-4	358.39	C₂₀H₂₂O₆