Fortunellin | CAS:20633-93-6 | Manufacturer ChemFaces

Fortunellin

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Size /Price /Stock	10 mM * 1 mL in DMSO / $229.0 / In-stock
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Description:

Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.

Targets:

miR-374a | PTEN | NF-κB | AMPK | Nrf2 | HO-1 | SOD | IKK | IκB

In vitro:

Biochemical and Biophysical Research Communications, 15 Jun 2017, 490(2):552-559.

Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.[Reference: WebLink]

Inflammation and oxidative stress contribute to the progression of diabetic cardiomyopathy (DCM). The study was first designed to calculate the role of an anti-inflammatory and anti-oxidant Fortunellin (For) in high fructose-induced cardiac injury in diabetic mice.
METHODS AND RESULTS:
Fortunellin was found to be none of toxicity to mice and cells using various assays. High fructose was used to induce mice with diabetes. The heart histopathological changes and cardiac function were measured. Fortunellin significantly attenuated the score of histopathological alterations and alleviated heart function, accompanied with reduced inflammation and oxidative stress. The pro-inflammatory cytokines and the expression of p-IκB kinase α (IKKα), p-IκBα, and p-nuclear factor-κB (NF-κB) were dramatically reduced by Fortunellin, while superoxide dismutase (SOD), catalase (CAT), heme oxygenase-1 (HO-1) and p-AMP-activated protein kinase (AMPK) were significantly enhanced. Moreover, in H9C2 cells with nuclear factor erythroid 2-related factor 2 (Nrf2) knock-down abolished the prevention of Fortunellin against cardiac injury, proved by elevated inflammatory response and oxidative stress. Suppression of p-AMPK reduced the level of Nrf2 and HO-1 induced by Fortunellin, eliminating the protective role of Fortunellin.
CONCLUSIONS:
For the first time, our study suggested that Fortunellin protected against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway in diabetic mice and cardiomyocytes with fructose treatment.

Fortunellin Description

Source:	The fruits of Fortunella japonica
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Frontiers in Immunology, 26 Jan 2018, 9:83.

Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis.[Reference: WebLink]

Activation of phosphatase and tensin homolog (PTEN) is known to induce cell apoptosis. MicroRNA-374a (miR-374a), which can suppress PTEN expression, has been found abnormally expressed in inflammatory bowel disease (IBD). Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. The present study investigated the effects and mechanisms underlying Fortunellin-induced inhibition of PTEN in IBD.
METHODS AND RESULTS:
Colitis was established in rats by the intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid to mimic human ulcerative colitis, which is the main type of IBD. miR-374a expression was measured by quantitative real-time polymerase chain reaction, and the regulation of PTEN by miR-374a was evaluated by dual luciferase reporter assay. Western blotting was used to measure the corresponding protein expression. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of Fortunellin on rat colitis.
CONCLUSIONS:
In conclusion, PTEN inhibition contributes to the amelioration effects of Fortunellin on colitis. It was confirmed that Fortunellin targets miR-374a, which is a negative regulator of PTEN. This study provides novel insights into the pathological mechanisms and treatment alternatives of colitis.

Product Name	Fortunellin
Price:	$318 / 10mg
CAS No.:	20633-93-6
Catalog No.:	CFN70305
Molecular Formula:	C₂₈H₃₂O₁₄
Molecular Weight:	592.6 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The fruits of Fortunella japonica
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library SOD Inhibitor Library PTEN Inhibitor Library Nrf2 Inhibitor Library IKK Inhibitor Library HO-1 Inhibitor Library AMPK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6875 mL	8.4374 mL	16.8748 mL	33.7496 mL	42.187 mL
5 mM	0.3375 mL	1.6875 mL	3.375 mL	6.7499 mL	8.4374 mL
10 mM	0.1687 mL	0.8437 mL	1.6875 mL	3.375 mL	4.2187 mL
50 mM	0.0337 mL	0.1687 mL	0.3375 mL	0.675 mL	0.8437 mL
100 mM	0.0169 mL	0.0844 mL	0.1687 mL	0.3375 mL	0.4219 mL

CFN90862	Perillen	539-52-6	150.2	C₁₀H₁₄O
CFN60169	NVP-AEW541	475489-16-8	439.55	C₂₇H₂₉N₅O
CFN92012	9-Methoxycanthin-6-one-N-oxide	137739-74-3	266.3	C₁₅H₁₀N₂O₃
CFN96009	4,5-Diepipsidial A	1219603-97-0	474.6	C₃₀H₃₄O₅