Frangulin B | CAS:14101-04-3 | Manufacturer ChemFaces

Frangulin B

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Frangulin B Description

Source:	The cortex of Rhamnus frangula L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Journal of Natural Products, 2014, 77(3):489-496.

Validated method for the analysis of frangulins A and B and glucofrangulins A and B using HPLC and UHPLC.[Reference: WebLink]

In the present study, robust and validated HPLC and UHPLC methods for the quantitative determination of frangulin A and Frangulin B (3 and 4) and glucofrangulins A and B (1 and 2) in the bark of Frangula alnus have been developed.
METHODS AND RESULTS:
The HPLC method allowed the separation of the analytes in 25 min and the UHPLC method in just 13 min. The HPLC method used an MN Nucleodur C18 125 × 4 mm column with 3 μm particles, while the UHPLC method used a Waters Acquity UPLC BEH C18, 100 × 2.1 mm column with 1.7 μm particles. Mobile phase A consisted of water and 1.25 mL/L phosphoric acid (85%), while mobile phase B consisted of CH3CN/MeOH (20:80). The flow rates were set to 1 mL/min for the HPLC method and 0.4 mL/min for the UHPLC method, with the column temperature held at 50 °C and the detection wavelength being 435 nm for either method. A fractional factorial design was used to check the robustness of the methods.
CONCLUSIONS:
The resolution of the analytes was never less than 1.5 when the factors were varied in the tested range. The conditions for ultrasonic extraction were optimized by response surface methodology and found to be 68% CH3CN in the extraction solvent, 35 °C extraction temperature, and a duration of 25 min. The extraction procedure was determined to be very robust against small deviations of these factors.

Product Name	Frangulin B
Price:
CAS No.:	14101-04-3
Catalog No.:	CFN70270
Molecular Formula:	C₂₀H₁₈O₉
Molecular Weight:	402.4 g/mol
Purity:	>=98$
Type of Compound:	Anthraquinones
Physical Desc.:	Powder
Source:	The cortex of Rhamnus frangula L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anthraquinones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4851 mL	12.4254 mL	24.8509 mL	49.7018 mL	62.1272 mL
5 mM	0.497 mL	2.4851 mL	4.9702 mL	9.9404 mL	12.4254 mL
10 mM	0.2485 mL	1.2425 mL	2.4851 mL	4.9702 mL	6.2127 mL
50 mM	0.0497 mL	0.2485 mL	0.497 mL	0.994 mL	1.2425 mL
100 mM	0.0249 mL	0.1243 mL	0.2485 mL	0.497 mL	0.6213 mL

CFN99592	Rhein-8-glucoside calcium salt	113443-70-2	484.43	C₂₁H₁₆O₁₁.Ca
CFN90066	Carmine	2611-82-7	534.9	C₂₀H₁₁N₂O₁₀S₃
CFN90434	Aloin B	28371-16-6	418.39	C₂₁H₂₂O₉
CFN95454	10-Hydroxyaloin B	134863-92-6	434.4	C₂₁H₂₂O₁₀
CFN91432	Aloinoside A	56645-88-6	564.5	C₂₇H₃₂O₁₃
CFN91461	Aloinoside B	11006-91-0	564.5	C₂₇H₃₂O₁₃
CFN95453	Barbaloin-related compound A	473225-21-7	834.8	C₄₂H₄₂O₁₈
CFN95455	Barbaloin-related compound B	473225-22-8	834.8	C₄₂H₄₂O₁₈
CFN70403	Cascaroside A	53823-08-8	580.5	C₂₇H₃₂O₁₄
CFN93123	Aloe-emodin-8-O-beta-D-glucopyranoside	33037-46-6	432.4	C₂₁H₂₀O₁₀