Furomollugin | CAS:61658-41-1 | Manufacturer ChemFaces

Furomollugin

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Description:

Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells.

Targets:

Antifection

In vitro:

J Nat Prod. 1996 Mar;59(3):330-3.

Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia.[Pubmed: 8882438]

METHODS AND RESULTS:
The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, Furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells while having little effect on the viability of the cells.
CONCLUSIONS:
Evaluation of structurally related derivatives of 1 and 2 revealed that a 6-hydroxy group and a pyran or furan ring contribute to this suppressive effect.

Furomollugin Description

Source:	The roots of Rubia cordifolia L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Nat Prod Commun. 2015 Jun;10(6):1025-6.

Phthalide Anions in Organic Synthesis. A Direct Total Synthesis of Furomollugin.[Pubmed: 26197542]

METHODS AND RESULTS:
Furomollugin was synthesized in three steps from commercially available starting materials using phthalide annulation chemistry.

Org Biomol Chem. 2013 Sep 28;11(36):6097-107.

A novel and efficient synthesis of diverse dihydronaphtho[1,2-b]furans using the ceric ammonium nitrate-catalyzed formal [3 + 2] cycloaddition of 1,4-naphthoquinones to olefins and its application to furomollugin.[Pubmed: 23963248]

METHODS AND RESULTS:
A novel approach was developed for the synthesis of diverse dihydronaphtho[1,2-b]furans from 1,4-naphthoquinones and olefins in the presence of ceric ammonium nitrate. This reaction provides a rapid route for the synthesis of a variety of dihydronaphtho[1,2-b]furans and naphtho[1,2-b]furans bearing different substituents.
CONCLUSIONS:
This methodology was also used to synthesize the biologically important natural product Furomollugin in only 2 steps.

Product Name	Furomollugin
Price:
CAS No.:	61658-41-1
Catalog No.:	CFN97055
Molecular Formula:	C₁₄H₁₀O₄
Molecular Weight:	242.2 g/mol
Purity:	>=98%
Type of Compound:	Naphthols
Physical Desc.:	Powder
Source:	The roots of Rubia cordifolia L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1288 mL	20.6441 mL	41.2882 mL	82.5764 mL	103.2205 mL
5 mM	0.8258 mL	4.1288 mL	8.2576 mL	16.5153 mL	20.6441 mL
10 mM	0.4129 mL	2.0644 mL	4.1288 mL	8.2576 mL	10.322 mL
50 mM	0.0826 mL	0.4129 mL	0.8258 mL	1.6515 mL	2.0644 mL
100 mM	0.0413 mL	0.2064 mL	0.4129 mL	0.8258 mL	1.0322 mL

CFN98441	Catalponol	34168-56-4	230.3	C₁₅H₁₈O₂
CFN98311	3-Hydroxycatalponol	265644-24-4	246.3	C₁₅H₁₈O₃
CFN99688	1-Hydroxy-2-prenylnaphthalene	16274-34-3	212.3	C₁₅H₁₆O
CFN99687	3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran	16274-33-2	212.3	C₁₅H₁₆O
CFN98930	Mollugin	55481-88-4	284.3	C₁₇H₁₆O₄
CFN95424	3-Hydroxymollugin	154706-45-3	300.3	C₁₇H₁₆O₅
CFN96857	3-Methoxymollugin	154706-44-2	314.33	C₁₈H₁₈O₅
CFN91030	Dihydromollugin	60657-93-4	286.32	C₁₇H₁₈O₄
CFN96847	Nonin A	1357351-29-1	300.31	C₁₇H₁₆O₅
CFN97055	Furomollugin	61658-41-1	242.2	C₁₄H₁₀O₄