Garcinone E | CAS:112649-21-5 | Manufacturer ChemFaces

Garcinone E

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Description:

Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.

Targets:

Antifection

In vitro:

Planta Med. 2002 Nov;68(11):975-9.

Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.[Pubmed: 12451486]

Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs.
METHODS AND RESULTS:
We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs.
CONCLUSIONS:
Our results have shown that one of the xanthone derivatives which could be identified as Garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that Garcinone E may be potentially useful for the treatment of certain types of cancer.

Garcinone E Description

Source:	The fruits of Garcinia mangostana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Garcinone E
Price:
CAS No.:	112649-21-5
Catalog No.:	CFN92697
Molecular Formula:	C₂₈H₃₂O₆
Molecular Weight:	464.6 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Yellow powder
Source:	The fruits of Garcinia mangostana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antioxidants Compound Library Xanthones Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1524 mL	10.7619 mL	21.5239 mL	43.0478 mL	53.8097 mL
5 mM	0.4305 mL	2.1524 mL	4.3048 mL	8.6096 mL	10.7619 mL
10 mM	0.2152 mL	1.0762 mL	2.1524 mL	4.3048 mL	5.381 mL
50 mM	0.043 mL	0.2152 mL	0.4305 mL	0.861 mL	1.0762 mL
100 mM	0.0215 mL	0.1076 mL	0.2152 mL	0.4305 mL	0.5381 mL

CFN89058	Parvifolixanthone A	906794-56-7	464.55	C₂₈H₃₂O₆
CFN89046	Latisxanthone C	197447-32-8	462.54	C₂₈H₃₀O₆
CFN92696	Butyraxanthone B	1141754-81-5	462.5	C₂₈H₃₀O₆
CFN92697	Garcinone E	112649-21-5	464.6	C₂₈H₃₂O₆
CFN97125	Isogarciniaxanthone E	659747-28-1	464.6	C₂₈H₃₂O₆
CFN99816	Garciniaxanthone E	173294-74-1	464.6	C₂₈H₃₂O₆
CFN96575	Sterigmatocystin	10048-13-2	324.29	C₁₈H₁₂O₆
CFN98089	Griffipavixanthone	219649-95-3	652.6	C₃₆H₂₈O₁₂
CFN96574	Bijaponicaxanthone C	872409-35-3	670.62	C₃₆H₃₀O₁₃