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Garcinone E
Garcinone E
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Garcinone E
Price:
CAS No.: 112649-21-5
Catalog No.: CFN92697
Molecular Formula: C28H32O6
Molecular Weight: 464.6 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Yellow powder
Source: The fruits of Garcinia mangostana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
Targets: Antifection
In vitro:
Planta Med. 2002 Nov;68(11):975-9.
Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.[Pubmed: 12451486]
Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs.
METHODS AND RESULTS:
We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs.
CONCLUSIONS:
Our results have shown that one of the xanthone derivatives which could be identified as Garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that Garcinone E may be potentially useful for the treatment of certain types of cancer.
Garcinone E Description
Source: The fruits of Garcinia mangostana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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IF=13.903(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1524 mL 10.7619 mL 21.5239 mL 43.0478 mL 53.8097 mL
5 mM 0.4305 mL 2.1524 mL 4.3048 mL 8.6096 mL 10.7619 mL
10 mM 0.2152 mL 1.0762 mL 2.1524 mL 4.3048 mL 5.381 mL
50 mM 0.043 mL 0.2152 mL 0.4305 mL 0.861 mL 1.0762 mL
100 mM 0.0215 mL 0.1076 mL 0.2152 mL 0.4305 mL 0.5381 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytother Res. 2010 Oct;24(10):1575-7.
Xanthone constituents of the fruits of Garcinia mangostana with anticomplement activity.[Pubmed: 20878711]

METHODS AND RESULTS:
Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones. The structures of these compounds were confirmed by interpretation of NMR and MS spectroscopic data.
CONCLUSIONS:
Of the isolates obtained, 1-isomangostin and Garcinone E were found to be active constituents in the anticomplement assay used.
CFN89058Parvifolixanthone A906794-56-7464.55C28H32O6
CFN89046Latisxanthone C197447-32-8462.54C28H30O6
CFN92696Butyraxanthone B1141754-81-5462.5C28H30O6
CFN92697Garcinone E112649-21-5464.6C28H32O6
CFN97125Isogarciniaxanthone E659747-28-1464.6 C28H32O6
CFN99816Garciniaxanthone E173294-74-1464.6 C28H32O6
CFN96575Sterigmatocystin10048-13-2324.29C18H12O6
CFN98089Griffipavixanthone219649-95-3652.6 C36H28O12
CFN96574Bijaponicaxanthone C872409-35-3670.62C36H30O13
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