Germanicol acetate | CAS:10483-91-7 | Manufacturer ChemFaces

Germanicol acetate

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Description:

Germanicol acetate shows some slight cytotoxic activity against Jurkat cells .

In vitro:

J Ethnopharmacol. 2016 May 13;183:29-37.

Cytotoxic biomonitored study of Euphorbia umbellata (Pax) Bruyns.[Pubmed: 26906968 ]

Euphorbia umbellata latex (sap) has normally been used in folk medicine in southern Brazil to treat different types of cancers. To carry out a biomonitored investigation of partitioned latex using in vitro assay, to identify the main mechanisms related with the action of the most active fraction as well as to develop a phytochemical study with this material.
METHODS AND RESULTS:
Biological screening was performed with hexane, chloroform, ethyl acetate and methanol fractions from the latex of E. umbellata using MTT, trypan blue, and neutral red assays to determine the cytotoxicity against HRT-18, HeLa and Jurkat cells and flow cytometry, DNA quantification, acridine orange and Hoechst 33342 staining to investigate mechanisms of action for the hexane extract. The phytochemical study of the hexane fraction was performed by chromatographic procedures and the substances were identified by NMR analysis. The isolated terpenes were evaluated using MTT to determine the cytotoxicity against Jurkat cells. All the fractions presented concentration and time dependent cytotoxicity. The hexane fraction showed the highest cytotoxicity; whereas the Jurkat cell was the lineage with the highest sensitivity (IC50 1.87µg/mL). Fragmentation of DNA and apoptosis are two mechanisms related with the toxicity of hexane fraction. The hexane fraction arrested the cell cycle in the G0/G1 phase, and the selectivity index was 4.30. Phytochemical study of the hexane fraction led to isolation of euphol (main compound) and Germanicol acetate. Both substances demonstrated some slight cytotoxic activity against Jurkat cells after 72h; however the activity was minimal compared to vincristine (anticancer standard drug).
CONCLUSIONS:
The current research proves that the fractions of the latex from E. umbellata have a cytotoxic effect against three different cancer cells lines. The hexane fraction showed high in vitro cytotoxic effects against Jurkat cells demonstrating that the effect may be due to non-polar constituents. The two isolated terpenes (euphol and Germanicol acetate) showed poor cytotoxic activity indicating that the anticancer properties of the extract may be caused by other substances present in the hexane fraction.

In vivo:

Saudi Pharm J. 2014 Nov;22(5):460-71.

Phytochemical and pharmacological study of Ficus palmata growing in Saudi Arabia.[Pubmed: 25473335 ]

Phytochemical study of the aerial parts of Ficus palmata utilizing liquid-liquid fractionation and different chromatographic techniques resulted in the isolation of a new isomer of psoralenoside namely, trans-psoralenoside (5) in addition to, one triterpene: Germanicol acetate (1), two furanocoumarins: psoralene (2), bergapten (3), one aromatic acid vanillic acid (4) and the flavone glycoside rutin (6).
METHODS AND RESULTS:
Structures of the isolated compounds were established through physical, 1D- and 2D-NMR and MS data. The total extract and fractions of the plant were examined in vivo for its possible effects as hepatoprotective, nephroprotective, antiulcer and anticoagulant activities in comparison with standard drugs. Hepatoprotective activity was assessed via serum biochemical parameters including aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP) and total bilirubin. Tissue parameters such as non-protein sulfhydryl groups (NP-SH), malonaldehyde (MDA) and total protein (TP) were also measured. In addition to tissue parameters, nephroprotective effect was evaluated by measuring the serum levels of sodium, potassium, creatinine and urea. Histopathological study for both liver and kidney cells was also conducted. Antiulcer activity was explored by observing stomach lesions after treatment with ethanol. Whole blood clotting time (CT) was taken as a measure for the anticoagulant activity of the extract. Antioxidant activity of the total extract and fractions of the plant was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and ascorbic acid as standard.

Germanicol acetate Description

Source:	The latex of Euphorbia umbellata (Pax) Bruyns.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Germanicol acetate
Price:
CAS No.:	10483-91-7
Catalog No.:	CFN96961
Molecular Formula:	C₃₂H₅₂O₂
Molecular Weight:	468.76 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The latex of Euphorbia umbellata (Pax) Bruyns.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1333 mL	10.6664 mL	21.3329 mL	42.6658 mL	53.3322 mL
5 mM	0.4267 mL	2.1333 mL	4.2666 mL	8.5332 mL	10.6664 mL
10 mM	0.2133 mL	1.0666 mL	2.1333 mL	4.2666 mL	5.3332 mL
50 mM	0.0427 mL	0.2133 mL	0.4267 mL	0.8533 mL	1.0666 mL
100 mM	0.0213 mL	0.1067 mL	0.2133 mL	0.4267 mL	0.5333 mL

CFN99679	beta-Amyrin acetate	1616-93-9	468.8	C₃₂H₅₂O₂
CFN97009	beta-Amyrin palmitate	5973-06-8	665.1	C₄₆H₈₀O₂
CFN97099	beta-Amyrone	638-97-1	424.7	C₃₀H₄₈O
CFN97528	9(11),12-Oleanadien-3-ol	94530-87-7	424.7	C₃₀H₄₈O
CFN94009	12-Oleanene-3,6-diol	41498-79-7	442.72	C₃₀H₅₀O₂
CFN94010	Daturaolone	41498-80-0	440.71	C₃₀H₄₈O₂
CFN96835	Rubiprasin B	125263-66-3	500.76	C₃₂H₅₂O₄
CFN96836	Rubiprasin A	125263-65-2	516.76	C₃₂H₅₂O₅
CFN98801	13(18)-Oleanen-3-ol	508-04-3	426.7	C₃₀H₅₀O
CFN98820	delta-Amyrin acetate	51361-60-5	468.8	C₃₂H₅₂O₂