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Guan-fu base A
Guan-fu base A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Guan-fu base A
Price:
CAS No.: 1394-48-5
Catalog No.: CFN91495
Molecular Formula: C24H31NO6
Molecular Weight: 429.5 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Aconitum coreanum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Anna University (India)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current. IC50 & Target:CYP2D6 HERG channel
Guan-fu base A Description
Source: The herbs of Aconitum coreanum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3283 mL 11.6414 mL 23.2829 mL 46.5658 mL 58.2072 mL
5 mM 0.4657 mL 2.3283 mL 4.6566 mL 9.3132 mL 11.6414 mL
10 mM 0.2328 mL 1.1641 mL 2.3283 mL 4.6566 mL 5.8207 mL
50 mM 0.0466 mL 0.2328 mL 0.4657 mL 0.9313 mL 1.1641 mL
100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.4657 mL 0.5821 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN9066312-Epinapelline110064-71-6359.5C22H33NO3
CFN90393Napellonine509-24-0357.49C22H31NO3
CFN96214Songoramine23179-78-4355.5C22H29NO3
CFN98058Spiradine F21040-64-2399.5 C24H33NO4
CFN99243Spiramine A114531-28-1399.5 C24H33NO4
CFN90228Bullatine A1354-84-3343.51C22H33NO2
CFN93074Karacoline39089-30-0377.52C22H35NO4
CFN91495Guan-fu base A1394-48-5429.5C24H31NO6
CFN89550Delgrandine145237-05-4741.77C41H43NO12
CFN8954714-Dehydrodelcosine1361-18-8451.55C24H37NO7
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