Hedychenone | CAS:56324-54-0 | Manufacturer ChemFaces

Hedychenone

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Hedychenone has anti-inflammatory activity, it also shows potent in vitro cytotoxic activity against cancerous cells.

Targets:

Immunology & Inflammation related

In vitro:

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2525-8.

Synthesis, cytotoxic activity and structure-activity relationships of hedychenone analogues.[Pubmed: 20303755]

Hedychenone, a plant-derived labdane diterpenoid, showed potent in vitro cytotoxic activity against cancerous cells.
METHODS AND RESULTS:
In the present study, a series of analogues have been synthesized by modification of the furanoid ring, double bond and the vinylic methyl functionality of this natural product lead and evaluated for their cytotoxic activities against human cancer cell lines. The structures of the target compounds were established by IR, (1)H NMR and mass spectral analysis. Majority of the analogues displayed potent activity than the parent compound, Hedychenone.
CONCLUSIONS:
Preliminary structure-activity relationship studies indicated that furanoid ring has a greater impact on cytotoxicity than that of the decalone nucleus. However, dimerization through C-8 significantly enhanced the cytotoxic activity of the Hedychenone.

Hedychenone Description

Source:	The rhizomes of Hedychium coronarium Koen.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Journal of Planar Chromatography - Modern TLC, 2007 , 20 (1) :73-74.

A new, convenient method for quantitative analysis of hedychenone, an anti-inflammatory compound in the rhizomes of Hedychium spicatum (Buch-Hem)[Reference: WebLink]

Plants of the Hedychium genus are perennial rhizomatus plants belonging to the Zingiberaceae family. Extracts of Zingiberacaea have long been used in traditional medicine.
METHODS AND RESULTS:
A simple, precise, and convenient HPTLC method has been established for analysis of Hedychenone, the major marker compound extracted from the rhizomes of Hedychium spicatum (Buch-Hem). Chromatography was performed on silica gel 60F 254 plates with ethyl acetate-hexane, 20 + 80 ( v/v ), as mobile phase. Detection and quantification were performed densitometrically at λ max = 254 nm with Hedychenone as external standard.
CONCLUSIONS:
The method is characterized by high sensitivity and linearity over a wide range of concentrations.

Product Name	Hedychenone
Price:
CAS No.:	56324-54-0
Catalog No.:	CFN98942
Molecular Formula:	C₂₀H₂₆O₂
Molecular Weight:	298.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The rhizomes of Hedychium coronarium Koen.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Cytotoxic Compound Library Diterpenoids Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3512 mL	16.756 mL	33.5121 mL	67.0241 mL	83.7802 mL
5 mM	0.6702 mL	3.3512 mL	6.7024 mL	13.4048 mL	16.756 mL
10 mM	0.3351 mL	1.6756 mL	3.3512 mL	6.7024 mL	8.378 mL
50 mM	0.067 mL	0.3351 mL	0.6702 mL	1.3405 mL	1.6756 mL
100 mM	0.0335 mL	0.1676 mL	0.3351 mL	0.6702 mL	0.8378 mL

CFN89151	Isoleojaponin	1840966-49-5	314.42	C₂₀H₂₆O₃
CFN89116	8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione	76475-32-6	376.49	C₂₂H₃₂O₅
CFN89108	6-Dehydroxy-8-hydroxygaleopsinolone	87440-66-2	316.44	C₂₀H₂₈O₃
CFN89065	Persianone	170894-20-9	632.88	C₄₀H₅₆O₆
CFN89110	Hispanone	82462-67-7	300.44	C₂₀H₂₈O₂
CFN89123	6alpha-Hydroxyhispanone	596814-48-1	316.44	C₂₀H₂₈O₃
CFN89162	6beta-Hydroxyhispanone	170711-93-0	316.44	C₂₀H₂₈O₃
CFN89087	Leojaponin	864817-63-0	314.42	C₂₀H₂₆O₃
CFN97053	15,16-Epoxy-12R-hydroxylabda-8(17),13(16),14-triene	61597-55-5	302.5	C₂₀H₃₀O₂
CFN98075	15,16-Epoxy-12S-hydroxylabda-8(17),13(16),14-triene	216011-55-1	302.5	C₂₀H₃₀O₂