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Interiotherin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Interiotherin A
Price:
CAS No.: 181701-06-4
Catalog No.: CFN92114
Molecular Formula: C29H28O8
Molecular Weight: 504.5 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Cryst.
Source: The fruits of Schisandra sphenanthera.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
Targets: HIV
In vitro:
J Nat Prod. 1996 Nov;59(11):1066-8.
Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.[Pubmed: 8946749 ]

METHODS AND RESULTS:
Two new lignans, Interiotherin A (1) and interiotherin B (2), along with two known lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and stereochemistries were determined from spectral data.
CONCLUSIONS:
Compounds 1 and 4 inhibit HIV replication with EC50 values of 3.1 and 0.5 micrograms/mL, respectively.
Interiotherin A Description
Source: The fruits of Schisandra sphenanthera.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9822 mL 9.9108 mL 19.8216 mL 39.6432 mL 49.554 mL
5 mM 0.3964 mL 1.9822 mL 3.9643 mL 7.9286 mL 9.9108 mL
10 mM 0.1982 mL 0.9911 mL 1.9822 mL 3.9643 mL 4.9554 mL
50 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.7929 mL 0.9911 mL
100 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.3964 mL 0.4955 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1597-601.
Chemical constituents of petroleum ether extract of fruits of Schisandra sphenanthera.[Pubmed: 22993989]
To study the chemical constituents in the fruits of Schisandra sphenanthera.
METHODS AND RESULTS:
The constituents were isolated by their silica gel column, Sephadex LH-20 gel column, and their structures were elucidated by their chemical properties and spectroscopic analyses. Twelve compounds were isolated and identified as (+)-anwulignan (1), deoxyschizandrin (2), Interiotherin A (3), schisantherin A (4), beta-sitosterol (5), schisantherin D (6), 4-hydroxybenzaldehyde (7), 6-O-benzoylgomisin O (8), schizandronic acid (9), schisanlactone D (10), schisanlactone B (11), kadsulactone A (12).
CONCLUSIONS:
Compounds 3, 7, 10-12 were obtained from this plant for the first time.
Trachelogenin

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CAS No: 34209-69-3
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Aloin A

Catalog No: CFN99943
CAS No: 1415-73-2
Price: $30/20mg
Platycodin A

Catalog No: CFN91977
CAS No: 66779-34-8
Price: $ / mg
Ginsenoside F5

Catalog No: CFN95034
CAS No: 189513-26-6
Price: $298/20mg
Guaijaverin

Catalog No: CFN98211
CAS No: 22255-13-6
Price: $138/20mg
Vicenin -2

Catalog No: CFN92031
CAS No: 23666-13-9
Price: $138/20mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Procyanidin B2

Catalog No: CFN99558
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Price: $138/20mg
Myrrhone

Catalog No: CFN91042
CAS No: 183551-83-9
Price: $388/5mg
Sakakin

Catalog No: CFN98059
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